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    ARL5B ADP ribosylation factor like GTPase 5B [ Homo sapiens (human) ]

    Gene ID: 221079, updated on 15-Jun-2019

    Summary

    Official Symbol
    ARL5Bprovided by HGNC
    Official Full Name
    ADP ribosylation factor like GTPase 5Bprovided by HGNC
    Primary source
    HGNC:HGNC:23052
    See related
    Ensembl:ENSG00000165997 MIM:608909
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ARL8
    Summary
    ARL5B (ARL8) belongs to a family of proteins that are structurally similar to ADP-ribosylation factors (ARFs; see MIM 103180). ARLs and ARFs are part of the RAS superfamily of regulatory GTPases.[supplied by OMIM, Nov 2010]
    Expression
    Ubiquitous expression in adrenal (RPKM 13.8), gall bladder (RPKM 10.5) and 25 other tissues See more
    Orthologs

    Genomic context

    See ARL5B in Genome Data Viewer
    Location:
    10p12.31
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 10 NC_000010.11 (18659335..18681639)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (18948264..18970568)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene calcium voltage-gated channel auxiliary subunit beta 2 Neighboring gene uncharacterized LOC107984213 Neighboring gene NOP2/Sun RNA methyltransferase 6 Neighboring gene uncharacterized LOC105376440 Neighboring gene AIFM1 pseudogene 1 Neighboring gene uncharacterized LOC107984180

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease.
    NHGRI GWA Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Nef nef Genome-wide shRNA screening identifies ARL5B, which is required for HIV-1 Nef-induced downregulation of CD4 in HeLa CD4+ cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein localization to Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein localization to Golgi membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    ADP-ribosylation factor-like protein 5B
    Names
    ADP-ribosylation factor-like 5B
    ADP-ribosylation factor-like 8
    ADP-ribosylation factor-like protein 8
    ADP-ribosylation-like factor 8

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_178815.5NP_848930.1  ADP-ribosylation factor-like protein 5B

      See identical proteins and their annotated locations for NP_848930.1

      Status: VALIDATED

      Source sequence(s)
      AL133611, AL512641
      Consensus CDS
      CCDS7131.1
      UniProtKB/Swiss-Prot
      Q96KC2
      UniProtKB/TrEMBL
      B0YIW9
      Related
      ENSP00000366487.3, ENST00000377275.4
      Conserved Domains (1) summary
      cd04153
      Location:3175
      Arl5_Arl8; Arf-like 5 (Arl5) and 8 (Arl8) GTPases

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

      Range
      18659335..18681639
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005252400.1XP_005252457.1  ADP-ribosylation factor-like protein 5B isoform X1

      See identical proteins and their annotated locations for XP_005252457.1

      Conserved Domains (2) summary
      smart00178
      Location:8148
      SAR; Sar1p-like members of the Ras-family of small GTPases
      cl21455
      Location:3147
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    2. XM_005252401.4XP_005252458.1  ADP-ribosylation factor-like protein 5B isoform X2

      See identical proteins and their annotated locations for XP_005252458.1

      Conserved Domains (1) summary
      cl21455
      Location:1138
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
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