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    SLC16A9 solute carrier family 16 member 9 [ Homo sapiens (human) ]

    Gene ID: 220963, updated on 11-Jun-2021

    Summary

    Official Symbol
    SLC16A9provided by HGNC
    Official Full Name
    solute carrier family 16 member 9provided by HGNC
    Primary source
    HGNC:HGNC:23520
    See related
    Ensembl:ENSG00000165449 MIM:614242
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MCT9; C10orf36
    Expression
    Biased expression in adrenal (RPKM 82.1), kidney (RPKM 62.2) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See SLC16A9 in Genome Data Viewer
    Location:
    10q21.2
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (59650764..59710079, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (61410522..61469837, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378318 Neighboring gene uncharacterized LOC105378319 Neighboring gene myoregulin Neighboring gene coiled-coil domain containing 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    An atlas of genetic influences on human blood metabolites.
    GeneReviews: Not available
    Gene-alcohol interactions identify several novel blood pressure loci including a promising locus near SLC16A9.
    GeneReviews: Not available
    Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.
    GeneReviews: Not available
    Human metabolic individuality in biomedical and pharmaceutical research.
    GeneReviews: Not available
    Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations.
    GeneReviews: Not available

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ43803

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables monocarboxylic acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables symporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in monocarboxylic acid transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in urate metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in integral component of membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    monocarboxylate transporter 9
    Names
    MCT 9
    monocarboxylic acid transporter 9
    solute carrier family 16 (monocarboxylic acid transporters), member 9

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001323977.1NP_001310906.1  monocarboxylate transporter 9 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3), as well as variants 4, 5, and 6, encodes isoform b.
      Source sequence(s)
      AC026391, DA759951
    2. NM_001323978.2NP_001310907.1  monocarboxylate transporter 9 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4), as well as variants 3, 5, and 6, encodes isoform b.
      Source sequence(s)
      AC022027, AC026391
    3. NM_001323979.2NP_001310908.1  monocarboxylate transporter 9 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5), as well as variants 3, 4, and 6, encodes isoform b.
      Source sequence(s)
      AC022027, AC026391
    4. NM_001323980.2NP_001310909.1  monocarboxylate transporter 9 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6), as well as variants 3, 4, and 5, encodes isoform b.
      Source sequence(s)
      AC022027, AC026391
    5. NM_001323981.2NP_001310910.1  monocarboxylate transporter 9 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2), as well as variant 1, encodes isoform a.
      Source sequence(s)
      AC022027, AC026391
      Consensus CDS
      CCDS7256.1
      UniProtKB/Swiss-Prot
      Q7RTY1
      Conserved Domains (1) summary
      cl26868
      Location:7481
      2A0111; oxalate/formate antiporter family transporter
    6. NM_194298.3NP_919274.1  monocarboxylate transporter 9 isoform a

      See identical proteins and their annotated locations for NP_919274.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1), as well as variant 2, encodes isoform a.
      Source sequence(s)
      AK125791, BC126238, BX092606, CX784319, DA229807
      Consensus CDS
      CCDS7256.1
      UniProtKB/Swiss-Prot
      Q7RTY1
      Related
      ENSP00000378757.3, ENST00000395348.8
      Conserved Domains (1) summary
      cl26868
      Location:7481
      2A0111; oxalate/formate antiporter family transporter

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

      Range
      59650764..59710079 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017015883.1XP_016871372.1  monocarboxylate transporter 9 isoform X1

    2. XM_017015884.2XP_016871373.1  monocarboxylate transporter 9 isoform X2

      UniProtKB/Swiss-Prot
      Q7RTY1
      Conserved Domains (1) summary
      cl26868
      Location:7481
      2A0111; oxalate/formate antiporter family transporter
    3. XM_024447878.1XP_024303646.1  monocarboxylate transporter 9 isoform X2

      Related
      ENSP00000378756.1, ENST00000395347.1
      Conserved Domains (1) summary
      cl26868
      Location:7481
      2A0111; oxalate/formate antiporter family transporter
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