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    Cd27 CD27 antigen [ Mus musculus (house mouse) ]

    Gene ID: 21940, updated on 16-Sep-2019

    Summary

    Official Symbol
    Cd27provided by MGI
    Official Full Name
    CD27 antigenprovided by MGI
    Primary source
    MGI:MGI:88326
    See related
    Ensembl:ENSMUSG00000030336
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    S152; Tp55; Tnfrsf7
    Expression
    Biased expression in thymus adult (RPKM 190.8), spleen adult (RPKM 23.5) and 1 other tissue See more
    Orthologs

    Genomic context

    See Cd27 in Genome Data Viewer
    Location:
    6 F2; 6 59.32 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    108 current GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (125232620..125237136, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (125182640..125187045, complement)

    Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene vesicle-associated membrane protein 1 Neighboring gene TAP binding protein-like Neighboring gene RIKEN cDNA E130112N10 gene Neighboring gene microRNA 8113 Neighboring gene predicted gene, 24175 Neighboring gene small nucleolar RNA SNORA70

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    cysteine-type endopeptidase inhibitor activity involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    B cell proliferation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    extrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    immunoglobulin secretion NAS
    Non-traceable Author Statement
    more info
    PubMed 
    negative regulation of T cell apoptotic process IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    negative regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of B cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of JNK cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of T cell differentiation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    positive regulation of interferon-gamma biosynthetic process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    CD27 antigen
    Names
    CD antigen 27
    CD27L receptor
    T-cell activation antigen CD27
    tumor necrosis factor receptor superfamily member 7

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033126.2NP_001028298.1  CD27 antigen isoform a precursor

      See identical proteins and their annotated locations for NP_001028298.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AA475779, AC140324, AI326735, DT924276
      Consensus CDS
      CCDS39639.1
      UniProtKB/Swiss-Prot
      P41272
      UniProtKB/TrEMBL
      Q3U4X0
      Related
      ENSMUSP00000032486.6, ENSMUST00000032486.12
      Conserved Domains (1) summary
      cd13408
      Location:4123
      TNFRSF7; Tumor necrosis factor receptor superfamily member 7 (TNFRSF7), also known as CD27
    2. NM_001042564.1NP_001036029.1  CD27 antigen isoform b precursor

      See identical proteins and their annotated locations for NP_001036029.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks two alternate in-frame exons in the 5' coding region, compared to variant 1. It encodes isoform b, which is shorter than isoform a.
      Source sequence(s)
      AC140324, AI326735, BE631582
      Consensus CDS
      CCDS39638.1
      UniProtKB/TrEMBL
      B7ZW87
      Related
      ENSMUSP00000107901.2, ENSMUST00000112282.2
      Conserved Domains (1) summary
      cl22855
      Location:445
      TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
    3. NM_001286753.1NP_001273682.1  CD27 antigen isoform c precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. It encodes isoform c, which is shorter than isoform a.
      Source sequence(s)
      AC140324, AI326735, DT924276
      Consensus CDS
      CCDS71839.1
      UniProtKB/TrEMBL
      D3Z7W5
      Related
      ENSMUSP00000107900.1, ENSMUST00000112281.7
      Conserved Domains (1) summary
      cl22855
      Location:489
      TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p6 C57BL/6J

    Genomic

    1. NC_000072.6 Reference GRCm38.p6 C57BL/6J

      Range
      125232620..125237136 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006505900.4XP_006505963.1  CD27 antigen isoform X3

      Conserved Domains (1) summary
      cl22855
      Location:489
      TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
    2. XM_006505898.4XP_006505961.1  CD27 antigen isoform X1

      Conserved Domains (1) summary
      cd13408
      Location:4123
      TNFRSF7; Tumor necrosis factor receptor superfamily member 7 (TNFRSF7), also known as CD27
    3. XM_006505901.4XP_006505964.1  CD27 antigen isoform X4

      Conserved Domains (1) summary
      cl22855
      Location:445
      TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
    4. XM_011241288.3XP_011239590.1  CD27 antigen isoform X2

      Conserved Domains (1) summary
      cl22855
      Location:479
      TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
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