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BPTF bromodomain PHD finger transcription factor [ Homo sapiens (human) ]

Gene ID: 2186, updated on 3-Apr-2024

Summary

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Official Symbol: BPTFprovided by HGNC
Official Full Name: bromodomain PHD finger transcription factorprovided by HGNC
Primary source: HGNC:HGNC:3581
See related: Ensembl:ENSG00000171634 MIM:601819; AllianceGenome:HGNC:3581
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: FAC1; FALZ; NEDDFL; NURF301
Summary: This gene was identified by the reactivity of its encoded protein to a monoclonal antibody prepared against brain homogenates from patients with Alzheimer's disease. Analysis of the original protein (fetal Alz-50 reactive clone 1, or FAC1), identified as an 810 aa protein containing a DNA-binding domain and a zinc finger motif, suggested it might play a role in the regulation of transcription. High levels of FAC1 were detected in fetal brain and in patients with neurodegenerative diseases. The protein encoded by this gene is actually much larger than originally thought, and it also contains a C-terminal bromodomain characteristic of proteins that regulate transcription during proliferation. The encoded protein is highly similar to the largest subunit of the Drosophila NURF (nucleosome remodeling factor) complex. In Drosophila, the NURF complex, which catalyzes nucleosome sliding on DNA and interacts with sequence-specific transcription factors, is necessary for the chromatin remodeling required for transcription. Two alternative transcripts encoding different isoforms have been described completely. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in testis (RPKM 8.1), lymph node (RPKM 8.1) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

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Location:: 17q24.2

Exon count:: 34

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	17	NC_000017.11 (67825503..67984378)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	17	NC_060941.1 (68700733..68859565)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	17	NC_000017.10 (65821619..65980494)

Chromosome 17 - NC_000017.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A role of BPTF in viral oncogenicity delineated through studies of heritable Kaposi sarcoma.
Title: A role of BPTF in viral oncogenicity delineated through studies of heritable Kaposi sarcoma.
PHF6 recruits BPTF to promote HIF-dependent pathway and progression in YAP-high breast cancer.
Title: PHF6 recruits BPTF to promote HIF-dependent pathway and progression in YAP-high breast cancer.
The effect of growth hormone treatment in children with novel BPTF gene variants: A report of two cases and literature review.
Title: The effect of growth hormone treatment in children with novel BPTF gene variants: A report of two cases and literature review.
Targeting regulation of VEGF by BPTF in non-small cell lung cancer and its potential clinical significance.
Title: Targeting regulation of VEGF by BPTF in non-small cell lung cancer and its potential clinical significance.
Upregulation of bromodomain PHD finger transcription factor in ovarian cancer and its critical role for cancer cell proliferation and survival.
Title: Upregulation of bromodomain PHD finger transcription factor in ovarian cancer and its critical role for cancer cell proliferation and survival.
Downregulated METTL14 accumulates BPTF that reinforces super-enhancers and distal lung metastasis via glycolytic reprogramming in renal cell carcinoma.
Title: Downregulated METTL14 accumulates BPTF that reinforces super-enhancers and distal lung metastasis via glycolytic reprogramming in renal cell carcinoma.
data indicate that miR-3666 could play an essential role in cell proliferation, migration, and invasiveness by targeting BPTF and partly inhibiting the PI3K-AKT and EMT signaling pathways in human lung cancers
Title: MicroRNA-3666 inhibits lung cancer cell proliferation, migration, and invasiveness by targeting BPTF.
Study identified a novel NSUN2 methylated lncRNA (NMR), which was significantly upregulated in esophageal squamous cell carcinoma (ESCC), functioned as a key regulator of ESCC tumor metastasis and drug resistance. NMR could directly bind to chromatin regulator BPTF, and potentially promote MMP3 and MMP10 expression by ERK1/2 pathway through recruiting BPTF to chromatin.
Title: Novel long noncoding RNA NMR promotes tumor progression via NSUN2 and BPTF in esophageal squamous cell carcinoma.
High BPTF expression is associated with gastric cancer growth and invasion.
Title: Circular RNA circ-DONSON facilitates gastric cancer growth and invasion via NURF complex dependent activation of transcription factor SOX4.
our data provide functional evidence and mechanistic insights that BPTF drives HCC progression, including promoting tumor cell proliferation, sustaining CSC traits, and increasing tumor metastasis, by transcriptionally activating the expression of hTERT.
Title: BPTF promotes hepatocellular carcinoma growth by modulating hTERT signaling and cancer stem cell traits.

Submit: New GeneRIF Correction See all GeneRIFs (25)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies MedGen: C4540327 OMIM: 617755 GeneReviews: Not available	Compare labs

Copy number response

Description
Copy number response Triplosensitivity No evidence available (Last evaluated 2022-07-12) ClinGen Genome Curation Page Haploinsufficency Sufficient evidence for dosage pathogenicity (Last evaluated 2022-07-12) ClinGen Genome Curation PagePubMed

EBI GWAS Catalog

Description
A genome-wide association study identifies two new susceptibility loci for lung adenocarcinoma in the Japanese population. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-57348 (e-PCR)
- UniSTS:21249

A007J48 (e-PCR)
- UniSTS:8199

D17S1772 (e-PCR)
- UniSTS:154128

RH12419 (e-PCR)
- UniSTS:85291

FALZ (e-PCR), detects polymorphism
- UniSTS:279603

RH104289 (e-PCR)
- UniSTS:98614

RH102527 (e-PCR)
- UniSTS:96861

RH78180 (e-PCR)
- UniSTS:48815

FALZ_8339 (e-PCR)
- UniSTS:467681

RH36156 (e-PCR)
- UniSTS:64755

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
contributes_to ATP-dependent activity, acting on DNA	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables methylated histone binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific DNA binding	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in anterior/posterior pattern specification	IEA Inferred from Electronic Annotation more info
involved_in brain development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in brain development	NAS Non-traceable Author Statement more info	PubMed
involved_in cellular response to nerve growth factor stimulus	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IDA Inferred from Direct Assay more info	PubMed
involved_in embryonic placenta development	IEA Inferred from Electronic Annotation more info
involved_in endoderm development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of ATPase complex	IDA Inferred from Direct Assay more info	PubMed
part_of NURF complex	IBA Inferred from Biological aspect of Ancestor more info
part_of NURF complex	IDA Inferred from Direct Assay more info	PubMed
part_of NURF complex	IPI Inferred from Physical Interaction more info	PubMed
located_in cell body	IEA Inferred from Electronic Annotation more info
part_of chromatin	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	TAS Traceable Author Statement more info	PubMed
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in extracellular exosome	HDA more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	NAS Non-traceable Author Statement more info	PubMed
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: nucleosome-remodeling factor subunit BPTF

Names: bromodomain and PHD domain transcription factor; bromodomain and PHD finger-containing transcription factor; fetal Alz-50 clone 1 protein; fetal Alz-50 reactive clone 1; fetal Alzheimer antigen; nucleosome remodeling factor, large subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_052828.1 RefSeqGene

Range

4987..163862

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_004459.7 → NP_004450.3 nucleosome-remodeling factor subunit BPTF isoform 2

See identical proteins and their annotated locations for NP_004450.3

Status: REVIEWED

Description

Transcript Variant: This variant (2) contains two additional in-frame exons in the 5' coding region and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.

Source sequence(s)

AB032251, AC006534, AC134407, AK022570, AK025776, AL833375, AY282495, BC037422

UniProtKB/TrEMBL

E7ETD6

Related

ENSP00000388405.3, ENST00000424123.7

Conserved Domains (6) summary

cd05509
Location:2788 → 2888

Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...

pfam09606
Location:2163 → 2583

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

cd15559
Location:392 → 434

PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)

cd15560
Location:2726 → 2772

PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)

pfam02791
Location:241 → 297

DDT; DDT domain

pfam15612
Location:339 → 388

WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
NM_182641.4 → NP_872579.2 nucleosome-remodeling factor subunit BPTF isoform 1

See identical proteins and their annotated locations for NP_872579.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AB032251, AC006534, AC134407, AK022570, AK025776, AY282495, BC037422, CV809604

Consensus CDS

CCDS11673.1

UniProtKB/TrEMBL

A0A2R8Y7Q1

Related

ENSP00000307208.6, ENST00000306378.11

Conserved Domains (6) summary

cd05509
Location:2805 → 2905

Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...

pfam09606
Location:2037 → 2418

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

cd15559
Location:392 → 434

PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)

cd15560
Location:2743 → 2789

PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)

pfam02791
Location:241 → 297

DDT; DDT domain

pfam15612
Location:339 → 388

WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000017.11 Reference GRCh38.p14 Primary Assembly

Range

67825503..67984378

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005257150.4 → XP_005257207.1 nucleosome-remodeling factor subunit BPTF isoform X1

UniProtKB/TrEMBL

A0A2R8Y7Q1, J3QQK4

Related

ENSP00000463776.2, ENST00000582467.2

Conserved Domains (7) summary

cd05509
Location:3043 → 3143

Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...

COG5034
Location:2742 → 2972

TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]

pfam09606
Location:2217 → 2598

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

cd15559
Location:392 → 434

PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)

cd15560
Location:2981 → 3027

PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)

pfam02791
Location:241 → 297

DDT; DDT domain

pfam15612
Location:339 → 388

WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
XM_005257154.4 → XP_005257211.1 nucleosome-remodeling factor subunit BPTF isoform X6

UniProtKB/TrEMBL

A0A2R8Y7Q1

Conserved Domains (6) summary

cd05509
Location:2985 → 3085

Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...

pfam09606
Location:2217 → 2598

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

cd15559
Location:392 → 434

PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)

cd15560
Location:2923 → 2969

PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)

pfam02791
Location:241 → 297

DDT; DDT domain

pfam15612
Location:339 → 388

WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
XM_005257159.3 → XP_005257216.1 nucleosome-remodeling factor subunit BPTF isoform X20

UniProtKB/TrEMBL

E9PE19

Conserved Domains (7) summary

cd05509
Location:2900 → 3000

Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...

COG5034
Location:2599 → 2829

TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]

pfam09606
Location:2217 → 2637

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

cd15559
Location:392 → 434

PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)

cd15560
Location:2838 → 2884

PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)

pfam02791
Location:241 → 297

DDT; DDT domain

pfam15612
Location:339 → 388

WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
XM_005257161.4 → XP_005257218.1 nucleosome-remodeling factor subunit BPTF isoform X27

UniProtKB/TrEMBL

E7ETD6

Conserved Domains (6) summary

cd05509
Location:2842 → 2942

Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...

pfam09606
Location:2217 → 2637

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

cd15559
Location:392 → 434

PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)

cd15560
Location:2780 → 2826

PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)

pfam02791
Location:241 → 297

DDT; DDT domain

pfam15612
Location:339 → 388

WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
XM_005257153.4 → XP_005257210.1 nucleosome-remodeling factor subunit BPTF isoform X5

UniProtKB/TrEMBL

A0A2R8Y7Q1

Related

ENSP00000496182.2, ENST00000644067.1

Conserved Domains (7) summary

cd05509
Location:2989 → 3089

Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...

COG5034
Location:2688 → 2918

TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]

pfam09606
Location:2163 → 2544

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

cd15559
Location:392 → 434

PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)

cd15560
Location:2927 → 2973

PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)

pfam02791
Location:241 → 297

DDT; DDT domain

pfam15612
Location:339 → 388

WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
XM_047435597.1 → XP_047291553.1 nucleosome-remodeling factor subunit BPTF isoform X13

UniProtKB/Swiss-Prot

Q12830, Q6NX67, Q7Z7D6, Q9UIG2

Related

ENSP00000315454.4, ENST00000321892.8
XM_005257160.3 → XP_005257217.1 nucleosome-remodeling factor subunit BPTF isoform X26

UniProtKB/TrEMBL

E9PE19

Related

ENSP00000343837.5, ENST00000342579.8

Conserved Domains (7) summary

cd05509
Location:2846 → 2946

Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...

COG5034
Location:2545 → 2775

TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]

pfam09606
Location:2163 → 2583

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

cd15559
Location:392 → 434

PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)

cd15560
Location:2784 → 2830

PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)

pfam02791
Location:241 → 297

DDT; DDT domain

pfam15612
Location:339 → 388

WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
XM_005257151.4 → XP_005257208.1 nucleosome-remodeling factor subunit BPTF isoform X3

UniProtKB/TrEMBL

A0A2R8Y7Q1

Conserved Domains (7) summary

cd05509
Location:3042 → 3142

Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...

COG5034
Location:2741 → 2971

TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]

pfam09606
Location:2216 → 2597

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

cd15559
Location:392 → 434

PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)

cd15560
Location:2980 → 3026

PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)

pfam02791
Location:241 → 297

DDT; DDT domain

pfam15612
Location:339 → 388

WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
XM_011524520.3 → XP_011522822.1 nucleosome-remodeling factor subunit BPTF isoform X2

UniProtKB/TrEMBL

A0A2R8Y7Q1

Conserved Domains (7) summary

cd05509
Location:3042 → 3142

Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...

COG5034
Location:2741 → 2971

TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]

pfam09606
Location:2216 → 2597

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

cd15559
Location:392 → 434

PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)

cd15560
Location:2980 → 3026

PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)

pfam02791
Location:241 → 297

DDT; DDT domain

pfam15612
Location:339 → 388

WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
XM_005257155.4 → XP_005257212.1 nucleosome-remodeling factor subunit BPTF isoform X7

UniProtKB/TrEMBL

A0A2R8Y7Q1

Conserved Domains (7) summary

cd05509
Location:2980 → 3080

Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...

COG5034
Location:2679 → 2909

TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]

pfam09606
Location:2154 → 2535

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

cd15559
Location:392 → 434

PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)

cd15560
Location:2918 → 2964

PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)

pfam02791
Location:241 → 297

DDT; DDT domain

pfam15612
Location:339 → 388

WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
XM_047435605.1 → XP_047291561.1 nucleosome-remodeling factor subunit BPTF isoform X28
XM_047435598.1 → XP_047291554.1 nucleosome-remodeling factor subunit BPTF isoform X14
XM_047435602.1 → XP_047291558.1 nucleosome-remodeling factor subunit BPTF isoform X22
XM_047435609.1 → XP_047291565.1 nucleosome-remodeling factor subunit BPTF isoform X32
XM_005257157.4 → XP_005257214.1 nucleosome-remodeling factor subunit BPTF isoform X10

UniProtKB/TrEMBL

A0A2R8Y7Q1

Conserved Domains (7) summary

cd05509
Location:2979 → 3079

Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...

COG5034
Location:2678 → 2908

TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]

pfam09606
Location:2153 → 2534

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

cd15559
Location:392 → 434

PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)

cd15560
Location:2917 → 2963

PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)

pfam02791
Location:241 → 297

DDT; DDT domain

pfam15612
Location:339 → 388

WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
XM_047435600.1 → XP_047291556.1 nucleosome-remodeling factor subunit BPTF isoform X16
XM_005257156.4 → XP_005257213.1 nucleosome-remodeling factor subunit BPTF isoform X8

UniProtKB/TrEMBL

A0A2R8Y7Q1

Conserved Domains (7) summary

cd05509
Location:2980 → 3080

Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...

COG5034
Location:2679 → 2909

TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]

pfam09606
Location:2154 → 2535

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

cd15559
Location:392 → 434

PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)

cd15560
Location:2918 → 2964

PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)

pfam02791
Location:241 → 297

DDT; DDT domain

pfam15612
Location:339 → 388

WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
XM_047435599.1 → XP_047291555.1 nucleosome-remodeling factor subunit BPTF isoform X15
XM_047435603.1 → XP_047291559.1 nucleosome-remodeling factor subunit BPTF isoform X23
XM_047435610.1 → XP_047291566.1 nucleosome-remodeling factor subunit BPTF isoform X33
XM_047435614.1 → XP_047291570.1 nucleosome-remodeling factor subunit BPTF isoform X37
XM_024450646.2 → XP_024306414.1 nucleosome-remodeling factor subunit BPTF isoform X11

UniProtKB/TrEMBL

A0A2R8Y7Q1

Conserved Domains (9) summary

cd05509
Location:2979 → 3079

Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...

smart00571
Location:240 → 299

DDT; domain in different transcription and chromosome remodeling factors

cd15559
Location:392 → 434

PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)

cd15560
Location:2917 → 2963

PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)

pfam09606
Location:2121 → 2496

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

pfam15612
Location:344 → 381

WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1

pfam15613
Location:456 → 524

WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif

cl02572
Location:1346 → 1605

PIPKc; Phosphatidylinositol phosphate kinases (PIPK) catalyze the phosphorylation of phosphatidylinositol phosphate on the fourth or fifth hydroxyl of the inositol ring, to form phosphatidylinositol bisphosphate. CD alignment includes type II ...

cl26267
Location:2678 → 2908

ING; Inhibitor of growth proteins N-terminal histone-binding
XM_047435611.1 → XP_047291567.1 nucleosome-remodeling factor subunit BPTF isoform X34
XM_005257158.4 → XP_005257215.1 nucleosome-remodeling factor subunit BPTF isoform X18

UniProtKB/TrEMBL

A0A2R8Y7Q1

Conserved Domains (7) summary

cd05509
Location:2917 → 3017

Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...

COG5034
Location:2616 → 2846

TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]

pfam09606
Location:2091 → 2472

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

cd15559
Location:392 → 434

PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)

cd15560
Location:2855 → 2901

PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)

pfam02791
Location:241 → 297

DDT; DDT domain

pfam15612
Location:339 → 388

WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
XM_047435613.1 → XP_047291569.1 nucleosome-remodeling factor subunit BPTF isoform X36
XM_047435604.1 → XP_047291560.1 nucleosome-remodeling factor subunit BPTF isoform X24
XM_047435615.1 → XP_047291571.1 nucleosome-remodeling factor subunit BPTF isoform X38
XM_047435617.1 → XP_047291573.1 nucleosome-remodeling factor subunit BPTF isoform X40
XM_011524522.3 → XP_011522824.1 nucleosome-remodeling factor subunit BPTF isoform X19

UniProtKB/TrEMBL

A0A2R8Y7Q1

Conserved Domains (7) summary

cd05509
Location:2916 → 3016

Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...

COG5034
Location:2615 → 2845

TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]

pfam09606
Location:2090 → 2471

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

cd15559
Location:392 → 434

PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)

cd15560
Location:2854 → 2900

PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)

pfam02791
Location:241 → 297

DDT; DDT domain

pfam15612
Location:339 → 388

WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
XM_011524523.3 → XP_011522825.1 nucleosome-remodeling factor subunit BPTF isoform X25

UniProtKB/TrEMBL

A0A2R8Y7Q1

Conserved Domains (7) summary

cd05509
Location:2862 → 2962

Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...

COG5034
Location:2561 → 2791

TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]

pfam09606
Location:2036 → 2417

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

cd15559
Location:392 → 434

PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)

cd15560
Location:2800 → 2846

PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)

pfam02791
Location:241 → 297

DDT; DDT domain

pfam15612
Location:339 → 388

WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
XM_011524525.3 → XP_011522827.1 nucleosome-remodeling factor subunit BPTF isoform X47

UniProtKB/TrEMBL

A0A2R8Y7Q1

Conserved Domains (6) summary

cd05509
Location:2804 → 2904

Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...

pfam09606
Location:2036 → 2417

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

cd15559
Location:392 → 434

PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)

cd15560
Location:2742 → 2788

PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)

pfam02791
Location:241 → 297

DDT; DDT domain

pfam15612
Location:339 → 388

WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
XM_047435616.1 → XP_047291572.1 nucleosome-remodeling factor subunit BPTF isoform X39
XM_011524526.3 → XP_011522828.1 nucleosome-remodeling factor subunit BPTF isoform X48

UniProtKB/TrEMBL

E7ETD6

Conserved Domains (6) summary

cd05509
Location:2661 → 2761

Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...

pfam09606
Location:2036 → 2456

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

cd15559
Location:392 → 434

PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)

cd15560
Location:2599 → 2645

PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)

pfam02791
Location:241 → 297

DDT; DDT domain

pfam15612
Location:339 → 388

WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
XM_017024353.3 → XP_016879842.1 nucleosome-remodeling factor subunit BPTF isoform X12

UniProtKB/TrEMBL

A0A2R8Y7Q1
XM_047435607.1 → XP_047291563.1 nucleosome-remodeling factor subunit BPTF isoform X30
XM_047435601.1 → XP_047291557.1 nucleosome-remodeling factor subunit BPTF isoform X17
XM_047435612.1 → XP_047291568.1 nucleosome-remodeling factor subunit BPTF isoform X35
XM_047435608.1 → XP_047291564.1 nucleosome-remodeling factor subunit BPTF isoform X31
XM_005257152.4 → XP_005257209.1 nucleosome-remodeling factor subunit BPTF isoform X4

UniProtKB/TrEMBL

A0A2R8Y7Q1

Conserved Domains (7) summary

cd05509
Location:3043 → 3143

Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...

COG5034
Location:2742 → 2972

TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]

pfam09606
Location:2217 → 2598

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

cd15559
Location:392 → 434

PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)

cd15560
Location:2981 → 3027

PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)

pfam02791
Location:241 → 297

DDT; DDT domain

pfam15612
Location:339 → 388

WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
XM_024450647.2 → XP_024306415.1 nucleosome-remodeling factor subunit BPTF isoform X21

UniProtKB/TrEMBL

E9PE19

Conserved Domains (9) summary

cd05509
Location:2900 → 3000

Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...

smart00571
Location:240 → 299

DDT; domain in different transcription and chromosome remodeling factors

cd15559
Location:392 → 434

PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)

cd15560
Location:2838 → 2884

PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)

pfam09606
Location:2175 → 2520

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

pfam15612
Location:344 → 381

WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1

pfam15613
Location:456 → 524

WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif

cl02572
Location:1410 → 1669

PIPKc; Phosphatidylinositol phosphate kinases (PIPK) catalyze the phosphorylation of phosphatidylinositol phosphate on the fourth or fifth hydroxyl of the inositol ring, to form phosphatidylinositol bisphosphate. CD alignment includes type II ...

cl26267
Location:2599 → 2829

ING; Inhibitor of growth proteins N-terminal histone-binding
XM_047435596.1 → XP_047291552.1 nucleosome-remodeling factor subunit BPTF isoform X9
XM_047435606.1 → XP_047291562.1 nucleosome-remodeling factor subunit BPTF isoform X29
XM_047435618.1 → XP_047291574.1 nucleosome-remodeling factor subunit BPTF isoform X41
XM_047435619.1 → XP_047291575.1 nucleosome-remodeling factor subunit BPTF isoform X42

Related

ENSP00000440854.2, ENST00000544778.6
XM_017024354.3 → XP_016879843.1 nucleosome-remodeling factor subunit BPTF isoform X43
XM_011524524.4 → XP_011522826.1 nucleosome-remodeling factor subunit BPTF isoform X44

Conserved Domains (4) summary

cd05509
Location:2073 → 2173

Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...

COG5034
Location:1772 → 2002

TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]

pfam09606
Location:1247 → 1628

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

cd15560
Location:2011 → 2057

PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
XM_047435620.1 → XP_047291576.1 nucleosome-remodeling factor subunit BPTF isoform X45
XM_047435621.1 → XP_047291577.1 nucleosome-remodeling factor subunit BPTF isoform X46

Alternate T2T-CHM13v2.0

Genomic

NC_060941.1 Alternate T2T-CHM13v2.0

Range

68700733..68859565

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054315429.1 → XP_054171404.1 nucleosome-remodeling factor subunit BPTF isoform X1

UniProtKB/TrEMBL

J3QQK4
XM_054315434.1 → XP_054171409.1 nucleosome-remodeling factor subunit BPTF isoform X6
XM_054315448.1 → XP_054171423.1 nucleosome-remodeling factor subunit BPTF isoform X20
XM_054315455.1 → XP_054171430.1 nucleosome-remodeling factor subunit BPTF isoform X27
XM_054315433.1 → XP_054171408.1 nucleosome-remodeling factor subunit BPTF isoform X5
XM_054315441.1 → XP_054171416.1 nucleosome-remodeling factor subunit BPTF isoform X13

UniProtKB/Swiss-Prot

Q12830, Q6NX67, Q7Z7D6, Q9UIG2
XM_054315454.1 → XP_054171429.1 nucleosome-remodeling factor subunit BPTF isoform X26
XM_054315431.1 → XP_054171406.1 nucleosome-remodeling factor subunit BPTF isoform X3
XM_054315430.1 → XP_054171405.1 nucleosome-remodeling factor subunit BPTF isoform X2
XM_054315435.1 → XP_054171410.1 nucleosome-remodeling factor subunit BPTF isoform X7
XM_054315456.1 → XP_054171431.1 nucleosome-remodeling factor subunit BPTF isoform X28
XM_054315442.1 → XP_054171417.1 nucleosome-remodeling factor subunit BPTF isoform X14
XM_054315450.1 → XP_054171425.1 nucleosome-remodeling factor subunit BPTF isoform X22
XM_054315460.1 → XP_054171435.1 nucleosome-remodeling factor subunit BPTF isoform X32
XM_054315438.1 → XP_054171413.1 nucleosome-remodeling factor subunit BPTF isoform X10
XM_054315444.1 → XP_054171419.1 nucleosome-remodeling factor subunit BPTF isoform X16
XM_054315436.1 → XP_054171411.1 nucleosome-remodeling factor subunit BPTF isoform X8
XM_054315443.1 → XP_054171418.1 nucleosome-remodeling factor subunit BPTF isoform X15
XM_054315451.1 → XP_054171426.1 nucleosome-remodeling factor subunit BPTF isoform X23
XM_054315461.1 → XP_054171436.1 nucleosome-remodeling factor subunit BPTF isoform X33
XM_054315465.1 → XP_054171440.1 nucleosome-remodeling factor subunit BPTF isoform X37
XM_054315439.1 → XP_054171414.1 nucleosome-remodeling factor subunit BPTF isoform X11
XM_054315462.1 → XP_054171437.1 nucleosome-remodeling factor subunit BPTF isoform X34
XM_054315446.1 → XP_054171421.1 nucleosome-remodeling factor subunit BPTF isoform X18
XM_054315464.1 → XP_054171439.1 nucleosome-remodeling factor subunit BPTF isoform X36
XM_054315452.1 → XP_054171427.1 nucleosome-remodeling factor subunit BPTF isoform X24
XM_054315466.1 → XP_054171441.1 nucleosome-remodeling factor subunit BPTF isoform X38
XM_054315468.1 → XP_054171443.1 nucleosome-remodeling factor subunit BPTF isoform X40
XM_054315447.1 → XP_054171422.1 nucleosome-remodeling factor subunit BPTF isoform X19
XM_054315453.1 → XP_054171428.1 nucleosome-remodeling factor subunit BPTF isoform X25
XM_054315475.1 → XP_054171450.1 nucleosome-remodeling factor subunit BPTF isoform X47
XM_054315467.1 → XP_054171442.1 nucleosome-remodeling factor subunit BPTF isoform X39
XM_054315476.1 → XP_054171451.1 nucleosome-remodeling factor subunit BPTF isoform X48
XM_054315440.1 → XP_054171415.1 nucleosome-remodeling factor subunit BPTF isoform X12
XM_054315458.1 → XP_054171433.1 nucleosome-remodeling factor subunit BPTF isoform X30
XM_054315445.1 → XP_054171420.1 nucleosome-remodeling factor subunit BPTF isoform X17
XM_054315463.1 → XP_054171438.1 nucleosome-remodeling factor subunit BPTF isoform X35
XM_054315459.1 → XP_054171434.1 nucleosome-remodeling factor subunit BPTF isoform X31
XM_054315432.1 → XP_054171407.1 nucleosome-remodeling factor subunit BPTF isoform X4
XM_054315449.1 → XP_054171424.1 nucleosome-remodeling factor subunit BPTF isoform X21
XM_054315437.1 → XP_054171412.1 nucleosome-remodeling factor subunit BPTF isoform X9
XM_054315457.1 → XP_054171432.1 nucleosome-remodeling factor subunit BPTF isoform X29
XM_054315469.1 → XP_054171444.1 nucleosome-remodeling factor subunit BPTF isoform X41
XM_054315470.1 → XP_054171445.1 nucleosome-remodeling factor subunit BPTF isoform X42
XM_054315471.1 → XP_054171446.1 nucleosome-remodeling factor subunit BPTF isoform X43
XM_054315472.1 → XP_054171447.1 nucleosome-remodeling factor subunit BPTF isoform X44
XM_054315473.1 → XP_054171448.1 nucleosome-remodeling factor subunit BPTF isoform X45
XM_054315474.1 → XP_054171449.1 nucleosome-remodeling factor subunit BPTF isoform X46