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    Th tyrosine hydroxylase [ Mus musculus (house mouse) ]

    Gene ID: 21823, updated on 9-Jul-2019

    Summary

    Official Symbol
    Thprovided by MGI
    Official Full Name
    tyrosine hydroxylaseprovided by MGI
    Primary source
    MGI:MGI:98735
    See related
    Ensembl:ENSMUSG00000000214
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Expression
    Biased expression in adrenal adult (RPKM 216.0) and frontal lobe adult (RPKM 33.7) See more
    Orthologs

    Genomic context

    Location:
    7 F5; 7 88.06 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (142892776..142899966, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (150078681..150085871, complement)

    Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene ribosomal protein L13 pseudogene Neighboring gene predicted gene, 39117 Neighboring gene achaete-scute family bHLH transcription factor 2 Neighboring gene tetraspanin 32 Neighboring gene expressed sequence R74862 Neighboring gene CD81 antigen

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (19)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    amino acid binding ISO
    Inferred from Sequence Orthology
    more info
     
    dopamine binding ISO
    Inferred from Sequence Orthology
    more info
     
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    ferric iron binding ISO
    Inferred from Sequence Orthology
    more info
     
    ferrous iron binding ISO
    Inferred from Sequence Orthology
    more info
     
    iron ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    monooxygenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen IEA
    Inferred from Electronic Annotation
    more info
     
    oxygen binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    tetrahydrobiopterin binding ISO
    Inferred from Sequence Orthology
    more info
     
    tyrosine 3-monooxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    tyrosine 3-monooxygenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    tyrosine 3-monooxygenase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    aminergic neurotransmitter loading into synaptic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    animal organ morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    aromatic amino acid family metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    catecholamine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    dopamine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    dopamine biosynthetic process from tyrosine IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    dopamine biosynthetic process from tyrosine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dopamine biosynthetic process from tyrosine IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    dopamine biosynthetic process from tyrosine ISO
    Inferred from Sequence Orthology
    more info
     
    dopamine biosynthetic process from tyrosine TAS
    Traceable Author Statement
    more info
    PubMed 
    eating behavior IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    eating behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    embryonic camera-type eye morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    epinephrine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    eye photoreceptor cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    heart development IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    heart development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    heart development ISO
    Inferred from Sequence Orthology
    more info
     
    learning IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    locomotory behavior IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mating behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    memory IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neurotransmitter biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    norepinephrine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of heart contraction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to ethanol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    response to ethanol ISO
    Inferred from Sequence Orthology
    more info
     
    response to hypoxia IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
     
    synaptic transmission, dopaminergic IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    visual perception IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    axon ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasmic side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasmic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    melanosome membrane ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    neuron projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    perikaryon IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    perikaryon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    perikaryon ISO
    Inferred from Sequence Orthology
    more info
     
    smooth endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    synaptic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    terminal bouton ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    tyrosine 3-monooxygenase
    Names
    tyrosine 3-hydroxylase
    NP_033403.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009377.2NP_033403.1  tyrosine 3-monooxygenase

      See identical proteins and their annotated locations for NP_033403.1

      Status: VALIDATED

      Source sequence(s)
      AK139568, BB868869, CJ194802
      Consensus CDS
      CCDS22036.1
      UniProtKB/Swiss-Prot
      P24529
      Related
      ENSMUSP00000000219.3, ENSMUST00000000219.9
      Conserved Domains (4) summary
      TIGR01269
      Location:38495
      Tyr_3_monoox; tyrosine 3-monooxygenase, tetrameric
      cd04930
      Location:38158
      ACT_TH; ACT domain of the nonheme iron-dependent aromatic amino acid hydroxylase, tyrosine hydroxylases (TH)
      pfam00351
      Location:165495
      Biopterin_H; Biopterin-dependent aromatic amino acid hydroxylase
      pfam12549
      Location:226
      TOH_N; Tyrosine hydroxylase N terminal

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

      Range
      142892776..142899966 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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