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    ACSL1 acyl-CoA synthetase long chain family member 1 [ Homo sapiens (human) ]

    Gene ID: 2180, updated on 22-Aug-2021

    Summary

    Official Symbol
    ACSL1provided by HGNC
    Official Full Name
    acyl-CoA synthetase long chain family member 1provided by HGNC
    Primary source
    HGNC:HGNC:3569
    See related
    Ensembl:ENSG00000151726 MIM:152425
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ACS1; LACS; FACL1; FACL2; LACS1; LACS2
    Summary
    The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]
    Expression
    Biased expression in fat (RPKM 357.3), liver (RPKM 217.4) and 10 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See ACSL1 in Genome Data Viewer
    Location:
    4q35.1
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (184755595..184826593, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (185676749..185747122, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene caspase 3 Neighboring gene primase and DNA directed polymerase Neighboring gene centromere protein U Neighboring gene proteoglycan 3, pro eosinophil major basic protein 2 pseudogene Neighboring gene uncharacterized LOC105377587 Neighboring gene MIR3945 host gene Neighboring gene microRNA 3945

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables arachidonate-CoA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables arachidonate-CoA ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables long-chain fatty acid-CoA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables long-chain fatty acid-CoA ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables long-chain fatty acid-CoA ligase activity TAS
    Traceable Author Statement
    more info
     
    enables oleoyl-CoA ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables phytanate-CoA ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables pristanate-CoA ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in adiponectin-activated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in fatty acid transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in lipid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in lipid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in lipid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in long-chain fatty acid import into cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in long-chain fatty acid import into cell ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in long-chain fatty acid metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in long-chain fatty-acyl-CoA biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in long-chain fatty-acyl-CoA biosynthetic process TAS
    Traceable Author Statement
    more info
     
    involved_in positive regulation of cold-induced thermogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in positive regulation of long-chain fatty acid import across plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in positive regulation of protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to nutrient IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to oleic acid IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to organic cyclic compound IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to xenobiotic stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in triglyceride biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in very long-chain fatty acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in xenobiotic catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
     
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane HDA PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in mitochondrial outer membrane TAS
    Traceable Author Statement
    more info
     
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in peroxisomal membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    long-chain-fatty-acid--CoA ligase 1
    Names
    LACS 1
    LACS 2
    acyl-CoA synthetase 1
    arachidonate--CoA ligase
    fatty-acid-Coenzyme A ligase, long-chain 1
    fatty-acid-Coenzyme A ligase, long-chain 2
    lignoceroyl-CoA synthase
    long-chain acyl-CoA synthetase 1
    long-chain acyl-CoA synthetase 2
    long-chain fatty acid-CoA ligase 2
    long-chain fatty-acid-coenzyme A ligase 1
    palmitoyl-CoA ligase 1
    palmitoyl-CoA ligase 2
    paltimoyl-CoA ligase 1
    phytanate--CoA ligase
    NP_001273637.1
    NP_001273639.1
    NP_001273640.1
    NP_001368806.1
    NP_001368807.1
    NP_001368808.1
    NP_001368809.1
    NP_001368810.1
    NP_001368811.1
    NP_001368812.1
    NP_001368813.1
    NP_001368814.1
    NP_001368815.1
    NP_001368816.1
    NP_001368817.1
    NP_001368818.1
    NP_001368819.1
    NP_001986.2
    XP_016863376.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001286708.2NP_001273637.1  long-chain-fatty-acid--CoA ligase 1 isoform a

      See identical proteins and their annotated locations for NP_001273637.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 6-12 all encode the same isoform (a).
      Source sequence(s)
      AC079257, AC084871
      Consensus CDS
      CCDS3839.1
      UniProtKB/Swiss-Prot
      P33121
      UniProtKB/TrEMBL
      A8K9T3
      Related
      ENSP00000425006.1, ENST00000504342.5
      Conserved Domains (1) summary
      cd05927
      Location:116694
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
    2. NM_001286710.2NP_001273639.1  long-chain-fatty-acid--CoA ligase 1 isoform b

      See identical proteins and their annotated locations for NP_001273639.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and has an alternate in-frame exon in place of another in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini and is the same length but has an alternate internal segment compared to isoform a. Variants 3 and 13-16 all encode the same isoform (b).
      Source sequence(s)
      AC079257, AC084871
      Consensus CDS
      CCDS68826.1
      UniProtKB/Swiss-Prot
      P33121
      UniProtKB/TrEMBL
      A8K9T3
      Related
      ENSP00000426150.1, ENST00000513317.5
      Conserved Domains (1) summary
      cd05927
      Location:116694
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
    3. NM_001286711.2NP_001273640.1  long-chain-fatty-acid--CoA ligase 1 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (c) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AC079257, AC084871
      Consensus CDS
      CCDS68825.1
      UniProtKB/Swiss-Prot
      P33121
      UniProtKB/TrEMBL
      A8K9T3, B4E0R0, E7EPM6
      Related
      ENSP00000426244.1, ENST00000507295.5
      Conserved Domains (2) summary
      PLN02736
      Location:86662
      PLN02736; long-chain acyl-CoA synthetase
      cd05927
      Location:116659
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
    4. NM_001381877.1NP_001368806.1  long-chain-fatty-acid--CoA ligase 1 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6), as well as variants 1, 2, and 7-12, encodes isoform a.
      Source sequence(s)
      AC079257, AC084871
      Conserved Domains (1) summary
      cd05927
      Location:116694
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
    5. NM_001381878.1NP_001368807.1  long-chain-fatty-acid--CoA ligase 1 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7), as well as variants 1, 2, 6, and 8-12, encodes isoform a.
      Source sequence(s)
      AC079257, AC084871
      Conserved Domains (1) summary
      cd05927
      Location:116694
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
    6. NM_001381879.1NP_001368808.1  long-chain-fatty-acid--CoA ligase 1 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8), as well as variants 1, 2, 6, 7, and 9-12, encodes isoform a.
      Source sequence(s)
      AC079257, AC084871
      Conserved Domains (1) summary
      cd05927
      Location:116694
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
    7. NM_001381880.1NP_001368809.1  long-chain-fatty-acid--CoA ligase 1 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9), as well as variants 1, 2, 6-8, and 10-12, encodes isoform a.
      Source sequence(s)
      AC079257, AC084871
      Conserved Domains (1) summary
      cd05927
      Location:116694
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
    8. NM_001381881.1NP_001368810.1  long-chain-fatty-acid--CoA ligase 1 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10), as well as variants 1, 2, 6-9, 11, and 12, encodes isoform a.
      Source sequence(s)
      AC079257, AC084871
      Conserved Domains (1) summary
      cd05927
      Location:116694
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
    9. NM_001381882.1NP_001368811.1  long-chain-fatty-acid--CoA ligase 1 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11), as well as variants 1, 2, 6-10, and 12, encodes isoform a.
      Source sequence(s)
      AC079257, AC084871
      Conserved Domains (1) summary
      cd05927
      Location:116694
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
    10. NM_001381883.1NP_001368812.1  long-chain-fatty-acid--CoA ligase 1 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12), as well as variants 1, 2, and 6-11, encodes isoform a.
      Source sequence(s)
      AC079257, AC084871
      Conserved Domains (1) summary
      cd05927
      Location:116694
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
    11. NM_001381884.1NP_001368813.1  long-chain-fatty-acid--CoA ligase 1 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (13), as well as variants 3 and 14-16, encodes isoform b.
      Source sequence(s)
      AC079257, AC084871
      Conserved Domains (1) summary
      cd05927
      Location:116694
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
    12. NM_001381885.1NP_001368814.1  long-chain-fatty-acid--CoA ligase 1 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (14), as well as variants 3, 13, 15, and 16, encodes isoform b.
      Source sequence(s)
      AC079257, AC084871
      Conserved Domains (1) summary
      cd05927
      Location:116694
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
    13. NM_001381886.1NP_001368815.1  long-chain-fatty-acid--CoA ligase 1 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (15), as well as variants 3, 13, 14, and 16, encodes isoform b.
      Source sequence(s)
      AC079257, AC084871
      Conserved Domains (1) summary
      cd05927
      Location:116694
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
    14. NM_001381887.1NP_001368816.1  long-chain-fatty-acid--CoA ligase 1 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (16), as well as variants 3 and 13-15, encodes isoform b.
      Source sequence(s)
      AC079257, AC084871
      Conserved Domains (1) summary
      cd05927
      Location:116694
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
    15. NM_001381888.1NP_001368817.1  long-chain-fatty-acid--CoA ligase 1 isoform e

      Status: REVIEWED

      Description
      Transcript Variant: This variant (17), as well as variant 18, encodes isoform e.
      Source sequence(s)
      AC079257, AC084871
      Conserved Domains (1) summary
      cd05927
      Location:67645
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
    16. NM_001381889.1NP_001368818.1  long-chain-fatty-acid--CoA ligase 1 isoform e

      Status: REVIEWED

      Description
      Transcript Variant: This variant (18), as well as variant 17, encodes isoform e.
      Source sequence(s)
      AC079257, AC084871
      Conserved Domains (1) summary
      cd05927
      Location:67645
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
    17. NM_001381890.1NP_001368819.1  long-chain-fatty-acid--CoA ligase 1 isoform f

      Status: REVIEWED

      Source sequence(s)
      AC079257, AC084871
      Conserved Domains (1) summary
      cd05927
      Location:52630
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
    18. NM_001995.5NP_001986.2  long-chain-fatty-acid--CoA ligase 1 isoform a

      See identical proteins and their annotated locations for NP_001986.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1, 2, and 6-12 all encode the same isoform (a).
      Source sequence(s)
      AC079257, AC084871
      Consensus CDS
      CCDS3839.1
      UniProtKB/Swiss-Prot
      P33121
      UniProtKB/TrEMBL
      A8K9T3
      Related
      ENSP00000281455.2, ENST00000281455.7
      Conserved Domains (1) summary
      cd05927
      Location:116694
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

    RNA

    1. NR_167698.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC079257, AC084871
    2. NR_167702.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC079257, AC084871
    3. NR_167703.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC079257, AC084871
      Related
      ENST00000454703.6
    4. NR_167704.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC079257, AC084871
    5. NR_167705.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC079257, AC084871
    6. NR_167706.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC079257, AC084871
    7. NR_167708.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC079257, AC084871
    8. NR_167709.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC079257, AC084871

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

      Range
      184755595..184826593 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017007887.1XP_016863376.1  long-chain-fatty-acid--CoA ligase 1 isoform X1

      UniProtKB/Swiss-Prot
      P33121
      Related
      ENSP00000422607.1, ENST00000515030.5
      Conserved Domains (1) summary
      cd05927
      Location:116694
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001286712.1: Suppressed sequence

      Description
      NM_001286712.1: This RefSeq was removed because currently there is support for the transcript but not for the protein.
    Support Center