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    Morf4l1 mortality factor 4 like 1 [ Mus musculus (house mouse) ]

    Gene ID: 21761, updated on 9-Dec-2024

    Summary

    Official Symbol
    Morf4l1provided by MGI
    Official Full Name
    mortality factor 4 like 1provided by MGI
    Primary source
    MGI:MGI:1096551
    See related
    Ensembl:ENSMUSG00000062270 AllianceGenome:MGI:1096551
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MRG15; Tex189; TEG-189; MORFRG15; mKIAA4002
    Summary
    Enables chromatin binding activity. Acts upstream of or within fibroblast proliferation. Predicted to be located in nuclear speck. Predicted to be part of NuA4 histone acetyltransferase complex; Sin3-type complex; and nucleosome. Is expressed in several structures, including genitourinary system; limb; liver; retina; and spleen. Orthologous to human MORF4L1 (mortality factor 4 like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis adult (RPKM 222.1), CNS E11.5 (RPKM 158.1) and 24 other tissues See more
    Orthologs
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    Genomic context

    See Morf4l1 in Genome Data Viewer
    Location:
    9 E3.1; 9 47.42 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (89973722..89996873, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (90091669..90114820, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_24879 Neighboring gene thymidine kinase 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_24880 Neighboring gene STARR-positive B cell enhancer ABC_E6787 Neighboring gene cathepsin H Neighboring gene STARR-positive B cell enhancer ABC_E2910 Neighboring gene STARR-seq mESC enhancer starr_24882 Neighboring gene transmembrane protein 41B, pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E9030 Neighboring gene nuclear encoded tRNA lysine 18 (anticodon CTT)

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Clone Names

    • KIAA4002, MGC102415, MGC103105, MGC118047

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of NuA4 histone acetyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of NuA4 histone acetyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of NuA4 histone acetyltransferase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of Sin3-type complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of Sin3-type complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    part_of nucleosome ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    mortality factor 4-like protein 1
    Names
    MORF-related gene 15 protein
    testis expressed gene 189
    testis-expressed gene 189 protein
    transcription factor-like protein MRG15

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039147.2NP_001034236.1  mortality factor 4-like protein 1 isoform a

      See identical proteins and their annotated locations for NP_001034236.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AC140392, BC085103
      Consensus CDS
      CCDS23400.1
      UniProtKB/Swiss-Prot
      P60762, Q8BNY9, Q99MQ0
      UniProtKB/TrEMBL
      Q3UIS6
      Related
      ENSMUSP00000082346.6, ENSMUST00000085248.12
      Conserved Domains (2) summary
      cd18983
      Location:15110
      CBD_MSL3_like; chromo barrel domain of human male-specific lethal complex subunit 3, and similar proteins
      pfam05712
      Location:184351
      MRG
    2. NM_001357780.1NP_001344709.1  mortality factor 4-like protein 1 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (c) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AC140392
      UniProtKB/TrEMBL
      Q3UIS6
      Conserved Domains (2) summary
      cd18983
      Location:15109
      CBD_MSL3_like; chromo barrel domain of human male-specific lethal complex subunit 3, and similar proteins
      pfam05712
      Location:183350
      MRG
    3. NM_024431.3NP_077751.1  mortality factor 4-like protein 1 isoform b

      See identical proteins and their annotated locations for NP_077751.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AC140392, AK167079, BC085103
      Consensus CDS
      CCDS52885.1
      UniProtKB/TrEMBL
      Q3UIS6, Q569V4
      Related
      ENSMUSP00000132020.2, ENSMUST00000169860.8
      Conserved Domains (2) summary
      cd18983
      Location:1571
      CBD_MSL3_like; chromo barrel domain of human male-specific lethal complex subunit 3, and similar proteins
      pfam05712
      Location:145312
      MRG

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      89973722..89996873 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)