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    Efemp1 epidermal growth factor-containing fibulin-like extracellular matrix protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 216616, updated on 12-Aug-2019

    Summary

    Official Symbol
    Efemp1provided by MGI
    Official Full Name
    epidermal growth factor-containing fibulin-like extracellular matrix protein 1provided by MGI
    Primary source
    MGI:MGI:1339998
    See related
    Ensembl:ENSMUSG00000020467
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Expression
    Broad expression in subcutaneous fat pad adult (RPKM 63.1), bladder adult (RPKM 60.9) and 17 other tissues See more
    Orthologs

    Genomic context

    See Efemp1 in Genome Data Viewer
    Location:
    11; 11 A3.3
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    108 current GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (28853154..28926743)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (28753205..28826743)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 40818 Neighboring gene microRNA 217 Neighboring gene predicted gene, 34185 Neighboring gene ribosomal protein SA, pseudogene 5 Neighboring gene polyribonucleotide nucleotidyltransferase 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Clone Names

    • MGC37612

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    epidermal growth factor receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    epidermal growth factor-activated receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular matrix structural constituent RCA
    inferred from Reviewed Computational Analysis
    more info
    PubMed 
    growth factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    epidermal growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of chondrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell projection organization ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of glial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    basement membrane ISO
    Inferred from Sequence Orthology
    more info
     
    collagen-containing extracellular matrix HDA PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space HDA PubMed 
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    EGF-containing fibulin-like extracellular matrix protein 1
    Names
    FIBL-3
    fibulin-3

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_146015.2NP_666127.2  EGF-containing fibulin-like extracellular matrix protein 1 precursor

      See identical proteins and their annotated locations for NP_666127.2

      Status: VALIDATED

      Source sequence(s)
      AK077302, AY251056
      Consensus CDS
      CCDS48761.1
      UniProtKB/Swiss-Prot
      Q8BPB5
      Related
      ENSMUSP00000020759.5, ENSMUST00000020759.11
      Conserved Domains (4) summary
      smart00179
      Location:214244
      EGF_CA; Calcium-binding EGF-like domain
      pfam07645
      Location:173206
      EGF_CA; Calcium-binding EGF domain
      pfam12662
      Location:274297
      cEGF; Complement Clr-like EGF-like
      cl00057
      Location:292325
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p6 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p6 C57BL/6J

      Range
      28853154..28926743
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030245798.1XP_030101658.1  EGF-containing fibulin-like extracellular matrix protein 1 isoform X2

    2. XM_030245799.1XP_030101659.1  EGF-containing fibulin-like extracellular matrix protein 1 isoform X3

    3. XM_006514660.1XP_006514723.1  EGF-containing fibulin-like extracellular matrix protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006514723.1

      UniProtKB/Swiss-Prot
      Q8BPB5
      Conserved Domains (4) summary
      smart00179
      Location:214244
      EGF_CA; Calcium-binding EGF-like domain
      pfam07645
      Location:173206
      EGF_CA; Calcium-binding EGF domain
      pfam12662
      Location:274297
      cEGF; Complement Clr-like EGF-like
      cl00057
      Location:292325
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
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