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    Alx1 ALX homeobox 1 [ Mus musculus (house mouse) ]

    Gene ID: 216285, updated on 11-Sep-2019

    Summary

    Official Symbol
    Alx1provided by MGI
    Official Full Name
    ALX homeobox 1provided by MGI
    Primary source
    MGI:MGI:104621
    See related
    Ensembl:ENSMUSG00000036602
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cart1; AI314867; C130005I02
    Expression
    Biased expression in testis adult (RPKM 6.2), CNS E11.5 (RPKM 2.3) and 3 other tissues See more
    Orthologs

    Genomic context

    See Alx1 in Genome Data Viewer
    Location:
    10 D1; 10 53.56 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    108 current GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (103007847..103029549, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (102470481..102491411, complement)

    Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene Ras association (RalGDS/AF-6) domain family (N-terminal) member 9 Neighboring gene predicted gene 5175 Neighboring gene predicted gene, 34298 Neighboring gene leucine-rich repeats and IQ motif containing 1 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene RIKEN cDNA 6430590A10 gene Neighboring gene solute carrier family 6 (neurotransmitter transporter), member 15

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    DNA-binding transcription activator activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
     
    DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    RNA polymerase II regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    RNA polymerase II regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    anterior/posterior pattern specification IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    embryonic limb morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    embryonic skeletal system morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    embryonic skeletal system morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    mesenchymal cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription, DNA-templated IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    neural crest cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    neural tube closure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of epithelial to mesenchymal transition ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    roof of mouth development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    ALX homeobox protein 1
    Names
    cartilage homeoprotein 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172553.4NP_766141.1  ALX homeobox protein 1

      See identical proteins and their annotated locations for NP_766141.1

      Status: VALIDATED

      Source sequence(s)
      AC167468
      Consensus CDS
      CCDS24155.1
      UniProtKB/Swiss-Prot
      Q8C8B0
      Related
      ENSMUSP00000042512.5, ENSMUST00000040859.5
      Conserved Domains (2) summary
      pfam00046
      Location:135188
      Homeobox; Homeobox domain
      pfam03826
      Location:302319
      OAR; OAR domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p6 C57BL/6J

    Genomic

    1. NC_000076.6 Reference GRCm38.p6 C57BL/6J

      Range
      103007847..103029549 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006513529.3XP_006513592.1  ALX homeobox protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006513592.1

      UniProtKB/Swiss-Prot
      Q8C8B0
      Related
      ENSMUSP00000151776.1, ENSMUST00000218282.1
      Conserved Domains (2) summary
      pfam00046
      Location:135188
      Homeobox; Homeobox domain
      pfam03826
      Location:302319
      OAR; OAR domain
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