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    Tcrb T cell receptor beta chain [ Mus musculus (house mouse) ]

    Gene ID: 21577, updated on 26-Jun-2024

    Summary

    Official Symbol
    Tcrbprovided by MGI
    Official Full Name
    T cell receptor beta chainprovided by MGI
    Primary source
    MGI:MGI:98578
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tib; TCRbeta
    Summary
    T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor beta locus. The beta locus includes V (variable), J (joining), diversity (D), and C (constant) segments. During T cell development, the beta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. Several V segments of the beta locus are known to be incapable of encoding a protein and are considered pseudogenes. The beta locus also includes several trypsinogen genes. [provided by RefSeq, Jul 2008]
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    Genomic context

    See Tcrb in Genome Data Viewer
    Location:
    6 B1; 6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (40868230..41535305)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (40891296..41558371)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene maltase-glucoamylase 2, pseudogene Neighboring gene STARR-seq mESC enhancer starr_15690 Neighboring gene RIKEN cDNA 1810009J06 gene Neighboring gene monooxygenase, DBH-like 2 Neighboring gene serine protease 58 Neighboring gene T cell receptor beta, variable 1 Neighboring gene serine protease 59 Neighboring gene trypsinogen pseudogene Neighboring gene STARR-seq mESC enhancer starr_15692 Neighboring gene STARR-positive B cell enhancer mm9_chr6:41005535-41005835 Neighboring gene predicted gene 2663 Neighboring gene serine protease 3B Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:41063415-41063598 Neighboring gene T cell receptor beta, variable 2 Neighboring gene T cell receptor beta, variable 3 Neighboring gene T cell receptor beta, variable 10 Neighboring gene T cell receptor beta, variable 5 Neighboring gene T cell receptor beta variable 6 Neighboring gene STARR-seq mESC enhancer starr_15693 Neighboring gene T cell receptor beta, variable 12-1 Neighboring gene T cell receptor beta variable 7 Neighboring gene T cell receptor beta variable 10 Neighboring gene T cell receptor beta, variable 13-1 Neighboring gene T cell receptor beta, variable 12-2 Neighboring gene T cell receptor beta variable 8 Neighboring gene STARR-seq mESC enhancer starr_15694 Neighboring gene T cell receptor beta, variable 13-2 Neighboring gene T cell receptor beta variable 9 Neighboring gene T cell receptor beta, variable 12-3 Neighboring gene T cell receptor beta variable 11 Neighboring gene T cell receptor beta, variable 13-3 Neighboring gene T cell receptor beta, variable 14 Neighboring gene T cell receptor beta, variable 15 Neighboring gene T cell receptor beta, variable 16 Neighboring gene T cell receptor beta, variable 17 Neighboring gene STARR-seq mESC enhancer starr_15695 Neighboring gene T cell receptor beta variable 18 Neighboring gene T cell receptor beta, variable 19 Neighboring gene T cell receptor beta, variable 20 Neighboring gene T cell receptor beta, variable 21 Neighboring gene T cell receptor beta variable 22 Neighboring gene T cell receptor beta, variable V23 Neighboring gene T cell receptor beta, variable 24 Neighboring gene T cell receptor beta variable 25 Neighboring gene T cell receptor beta, variable 26 Neighboring gene STARR-seq mESC enhancer starr_15697 Neighboring gene protein tyrosine phosphatase domain containing 1 pseudogene Neighboring gene T cell receptor beta variable 27 Neighboring gene T cell receptor beta variable 28 Neighboring gene T cell receptor beta variable 29 Neighboring gene T cell receptor beta, variable 30 Neighboring gene cell division cycle 42 homolog pseudogene Neighboring gene trypsin 4 Neighboring gene trypsin 5 Neighboring gene STARR-seq mESC enhancer starr_15698 Neighboring gene trypsin 10 Neighboring gene serine protease 3 Neighboring gene serine protease 1 (trypsin 1) like Neighboring gene STARR-seq mESC enhancer starr_15699 Neighboring gene Try10-like trypsinogen pseudogene Neighboring gene serine protease 3 like Neighboring gene STARR-seq mESC enhancer starr_15700 Neighboring gene STARR-positive B cell enhancer mm9_chr6:41480095-41480396 Neighboring gene serine protease 1 (trypsin 1) Neighboring gene STARR-seq mESC enhancer starr_15701 Neighboring gene proline-rich polypeptide 3 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:41504290-41504605 Neighboring gene STARR-seq mESC enhancer starr_15702 Neighboring gene STARR-seq mESC enhancer starr_15703 Neighboring gene T cell receptor beta joining 1-3 Neighboring gene T cell receptor beta joining 1-2 Neighboring gene T cell receptor beta joining 1-1 Neighboring gene T cell receptor beta joining 1-5 Neighboring gene T cell receptor beta joining 1-6 Neighboring gene T cell receptor beta joining 1-7 Neighboring gene T cell receptor beta joining 1-4 Neighboring gene STARR-seq mESC enhancer starr_15704 Neighboring gene T cell receptor beta joining 2-5 Neighboring gene T cell receptor beta joining 2-6 Neighboring gene T cell receptor beta joining 2-4 Neighboring gene T cell receptor beta joining 2-3 Neighboring gene T cell receptor beta joining 2-2 Neighboring gene T cell receptor beta joining 2-1 Neighboring gene T cell receptor beta joining 2-7 Neighboring gene serine protease 2 Neighboring gene T cell receptor beta, D region 1 Neighboring gene T cell receptor beta, constant region 1 Neighboring gene T cell receptor beta, D region 2 Neighboring gene T cell receptor beta, constant 2 Neighboring gene T cell receptor beta, variable 31 Neighboring gene predicted gene, 27549 Neighboring gene Eph receptor B6

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables peptide binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of alpha-beta T cell receptor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in immunological synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_006980.1 

      Range
      502..667577
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      40868230..41535305
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)