U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Tacr3 tachykinin receptor 3 [ Mus musculus (house mouse) ]

    Gene ID: 21338, updated on 18-Sep-2024

    Summary

    Official Symbol
    Tacr3provided by MGI
    Official Full Name
    tachykinin receptor 3provided by MGI
    Primary source
    MGI:MGI:892968
    See related
    Ensembl:ENSMUSG00000028172 AllianceGenome:MGI:892968
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nkr; Nk3r; Tac3r
    Summary
    This gene belongs to a family of genes that function as receptors for tachykinins. The receptors belonging to this family are characterized by interactions with G proteins and 7 hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin neurokinin 3, also referred to as neurokinin B. [provided by RefSeq, Mar 2010]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Tacr3 in Genome Data Viewer
    Location:
    3 G3; 3 62.47 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (134534768..134640342)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (134829007..134934581)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930539C22 gene Neighboring gene peptidylprolyl isomerase A pseudogene 3_1390.1 Neighboring gene STARR-seq mESC enhancer starr_09046 Neighboring gene STARR-seq mESC enhancer starr_09047 Neighboring gene STARR-seq mESC enhancer starr_09049 Neighboring gene STARR-seq mESC enhancer starr_09050 Neighboring gene adaptor-related protein complex AP-1, sigma 3 pseudogene Neighboring gene DCN1, defective in cullin neddylation 1, domain containing 2 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (6)  1 citation

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables tachykinin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables tachykinin receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables tachykinin receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in positive regulation of blood pressure IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of blood pressure ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of flagellated sperm motility IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of flagellated sperm motility IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of flagellated sperm motility ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of heart rate IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of heart rate ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of uterine smooth muscle contraction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of uterine smooth muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of dopamine metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of dopamine metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of feeding behavior IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of feeding behavior ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to cocaine IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to cocaine ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to estradiol IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to estradiol ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in tachykinin receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in dendrite membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in dendrite membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuronal cell body membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in sperm midpiece IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in sperm midpiece IEA
    Inferred from Electronic Annotation
    more info
     
    located_in sperm midpiece ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    neuromedin-K receptor
    Names
    NK-3 receptor
    Nk3 receptor
    neurokinin 3 receptor
    neurokinin B receptor
    neuromedin K receptor
    NP_067357.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021382.6NP_067357.1  neuromedin-K receptor

      See identical proteins and their annotated locations for NP_067357.1

      Status: REVIEWED

      Source sequence(s)
      AC101889, AK031898, AV336806
      Consensus CDS
      CCDS17852.1
      UniProtKB/Swiss-Prot
      P47937, Q61968, Q8BL44, Q9JKN0
      UniProtKB/TrEMBL
      Q6NXX1
      Related
      ENSMUSP00000029822.5, ENSMUST00000029822.6
      Conserved Domains (2) summary
      pfam00001
      Location:89343
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:81204
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      134534768..134640342
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)