Format

Send to:

Choose Destination
    • Showing Current items.

    ETV4 ETS variant 4 [ Homo sapiens (human) ]

    Gene ID: 2118, updated on 15-Jun-2019

    Summary

    Official Symbol
    ETV4provided by HGNC
    Official Full Name
    ETS variant 4provided by HGNC
    Primary source
    HGNC:HGNC:3493
    See related
    Ensembl:ENSG00000175832 MIM:600711
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    E1AF; PEA3; E1A-F; PEAS3
    Expression
    Broad expression in thyroid (RPKM 3.5), brain (RPKM 3.4) and 20 other tissues See more
    Orthologs

    Genomic context

    See ETV4 in Genome Data Viewer
    Location:
    17q21.31
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 17 NC_000017.11 (43527843..43546432, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (41605211..41623800, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 971, pseudogene Neighboring gene ribosomal protein L29 pseudogene 31 Neighboring gene DEAH-box helicase 8 Neighboring gene mesenchyme homeobox 1 Neighboring gene uncharacterized LOC107985085 Neighboring gene long intergenic non-protein coding RNA 2594

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    nucleolus IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    ETS translocation variant 4
    Names
    EWS protein/E1A enhancer binding protein chimera
    adenovirus E1A enhancer-binding protein
    ets variant gene 4 (E1A enhancer-binding protein, E1AF)
    polyomavirus enhancer activator 3 homolog

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001079675.5NP_001073143.1  ETS translocation variant 4 isoform 1

      See identical proteins and their annotated locations for NP_001073143.1

      Status: VALIDATED

      Source sequence(s)
      AC068675
      Consensus CDS
      CCDS11465.1
      UniProtKB/Swiss-Prot
      P43268
      Related
      ENSP00000321835.4, ENST00000319349.10
      Conserved Domains (2) summary
      smart00413
      Location:341424
      ETS; erythroblast transformation specific domain
      pfam04621
      Location:8339
      ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain
    2. NM_001261437.3NP_001248366.1  ETS translocation variant 4 isoform 2

      See identical proteins and their annotated locations for NP_001248366.1

      Status: VALIDATED

      Source sequence(s)
      AC068675
      Consensus CDS
      CCDS58553.1
      UniProtKB/Swiss-Prot
      P43268
      Related
      ENSP00000440023.1, ENST00000545954.5
      Conserved Domains (2) summary
      smart00413
      Location:302385
      ETS; erythroblast transformation specific domain
      pfam04621
      Location:8300
      ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain
    3. NM_001261438.3NP_001248367.1  ETS translocation variant 4 isoform 2

      See identical proteins and their annotated locations for NP_001248367.1

      Status: VALIDATED

      Source sequence(s)
      AC068675
      Consensus CDS
      CCDS58553.1
      UniProtKB/Swiss-Prot
      P43268
      Related
      ENSP00000443846.1, ENST00000538265.5
      Conserved Domains (2) summary
      smart00413
      Location:302385
      ETS; erythroblast transformation specific domain
      pfam04621
      Location:8300
      ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain
    4. NM_001261439.3NP_001248368.1  ETS translocation variant 4 isoform 3

      See identical proteins and their annotated locations for NP_001248368.1

      Status: VALIDATED

      Source sequence(s)
      AC068675
      Consensus CDS
      CCDS59292.1
      UniProtKB/Swiss-Prot
      P43268
      Related
      ENSP00000468636.1, ENST00000586826.1
      Conserved Domains (2) summary
      smart00413
      Location:64147
      ETS; erythroblast transformation specific domain
      pfam04621
      Location:162
      ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain
    5. NM_001369366.2NP_001356295.1  ETS translocation variant 4 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC068675
      Conserved Domains (2) summary
      smart00413
      Location:341424
      ETS; erythroblast transformation specific domain
      pfam04621
      Location:8339
      ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain
    6. NM_001369367.2NP_001356296.1  ETS translocation variant 4 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC068675
    7. NM_001369368.2NP_001356297.1  ETS translocation variant 4 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC068675
    8. NM_001986.4NP_001977.1  ETS translocation variant 4 isoform 1

      See identical proteins and their annotated locations for NP_001977.1

      Status: VALIDATED

      Source sequence(s)
      AC068675
      Consensus CDS
      CCDS11465.1
      UniProtKB/Swiss-Prot
      P43268
      Related
      ENSP00000465718.1, ENST00000591713.5
      Conserved Domains (2) summary
      smart00413
      Location:341424
      ETS; erythroblast transformation specific domain
      pfam04621
      Location:8339
      ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

      Range
      43527843..43546340 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024450644.1XP_024306412.1  ETS translocation variant 4 isoform X2

      Conserved Domains (2) summary
      smart00413
      Location:78161
      ETS; erythroblast transformation specific domain
      pfam04621
      Location:876
      ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain
    Support Center