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    Syt1 synaptotagmin I [ Mus musculus (house mouse) ]

    Gene ID: 20979, updated on 26-Nov-2016
    Official Symbol
    Syt1provided by MGI
    Official Full Name
    synaptotagmin Iprovided by MGI
    Primary source
    MGI:MGI:99667
    See related
    Ensembl:ENSMUSG00000035864 Vega:OTTMUSG00000016266
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SytI; AW124717; G630098F17Rik
    Orthologs
    Location:
    10 D1; 10 56.52 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 10 NC_000076.6 (108497650..109010978, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (107935305..108447675, complement)

    Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105245279 Neighboring gene predicted gene, 40755 Neighboring gene PRKC, apoptosis, WT1, regulator Neighboring gene predicted gene, 36283 Neighboring gene predicted gene, 36440 Neighboring gene predicted gene 5136 Neighboring gene predicted gene, 40757 Neighboring gene neuron navigator 3

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    SNARE binding ISO
    Inferred from Sequence Orthology
    more info
     
    calcium ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    calcium-dependent phospholipid binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    calcium-dependent phospholipid binding ISO
    Inferred from Sequence Orthology
    more info
     
    calcium-dependent phospholipid binding TAS
    Traceable Author Statement
    more info
    PubMed 
    calcium-dependent protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    calcium-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    calmodulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    clathrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    clathrin binding ISO
    Inferred from Sequence Orthology
    more info
     
    low-density lipoprotein particle receptor binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatidylinositol-4,5-bisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    phosphatidylinositol-4,5-bisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
     
    phosphatidylserine binding ISO
    Inferred from Sequence Orthology
    more info
     
    phospholipid binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein C-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    syntaxin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    syntaxin binding ISO
    Inferred from Sequence Orthology
    more info
     
    syntaxin-1 binding ISO
    Inferred from Sequence Orthology
    more info
     
    syntaxin-3 binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to calcium ion ISO
    Inferred from Sequence Orthology
    more info
     
    detection of calcium ion ISO
    Inferred from Sequence Orthology
    more info
     
    fast, calcium ion-dependent exocytosis of neurotransmitter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    fast, calcium ion-dependent exocytosis of neurotransmitter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neurotransmitter secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of calcium ion-dependent exocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of dendrite extension ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of vesicle fusion ISO
    Inferred from Sequence Orthology
    more info
     
    protein heterooligomerization ISO
    Inferred from Sequence Orthology
    more info
     
    protein homooligomerization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of calcium ion-dependent exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of calcium ion-dependent exocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of dopamine secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of regulated secretory pathway ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of synaptic transmission, glutamatergic IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to calcium ion ISO
    Inferred from Sequence Orthology
    more info
     
    synaptic vesicle endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    synaptic vesicle exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    vesicle docking ISO
    Inferred from Sequence Orthology
    more info
     
    vesicle fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with SNARE complex ISO
    Inferred from Sequence Orthology
    more info
     
    axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    dense core granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dense core granule ISO
    Inferred from Sequence Orthology
    more info
     
    excitatory synapse ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular organelle ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    neuron projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuron projection terminus ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    presynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    secretory granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    secretory granule ISO
    Inferred from Sequence Orthology
    more info
     
    synapse IEA
    Inferred from Electronic Annotation
    more info
     
    synaptic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    synaptic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    synaptic vesicle TAS
    Traceable Author Statement
    more info
    PubMed 
    synaptic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    terminal bouton ISO
    Inferred from Sequence Orthology
    more info
     

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252341.1NP_001239270.1  synaptotagmin-1 isoform 1

      See identical proteins and their annotated locations for NP_001239270.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and it encodes the longer protein (isoform 1). Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AI842617, AK078790, BC042519, BY268027, CD774438
      Consensus CDS
      CCDS24163.1
      UniProtKB/Swiss-Prot
      P46096
      UniProtKB/TrEMBL
      H6RXZ1
      Related
      ENSMUSP00000100912, OTTMUSP00000017428, ENSMUST00000105276, OTTMUST00000039005
      Conserved Domains (2) summary
      cd08385
      Location:142264
      C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
      cd08402
      Location:273408
      C2B_Synaptotagmin-1; C2 domain second repeat present in Synaptotagmin 1
    2. NM_001252342.1NP_001239271.1  synaptotagmin-1 isoform 2

      See identical proteins and their annotated locations for NP_001239271.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate exon in the 5' UTR and uses a difference splice site in the coding region, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.
      Source sequence(s)
      AI842617, AK018163, AK133578, BC042519, BY268027, CD774438
      UniProtKB/Swiss-Prot
      P46096
      Conserved Domains (2) summary
      cd08385
      Location:139261
      C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
      cd08402
      Location:270405
      C2B_Synaptotagmin-1; C2 domain second repeat present in Synaptotagmin 1
    3. NM_009306.3NP_033332.1  synaptotagmin-1 isoform 1

      See identical proteins and their annotated locations for NP_033332.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein (isoform 1).
      Source sequence(s)
      AI842617, BC042519, BY238701, BY268027, CD774438
      Consensus CDS
      CCDS24163.1
      UniProtKB/Swiss-Prot
      P46096
      UniProtKB/TrEMBL
      H6RXZ1
      Related
      ENSMUSP00000063293, OTTMUSP00000021532, ENSMUST00000064054, OTTMUST00000047565
      Conserved Domains (2) summary
      cd08385
      Location:142264
      C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
      cd08402
      Location:273408
      C2B_Synaptotagmin-1; C2 domain second repeat present in Synaptotagmin 1

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000076.6 Reference GRCm38.p4 C57BL/6J

      Range
      108497650..109010978 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017313867.1XP_017169356.1  

      Conserved Domains (2) summary
      cd08385
      Location:139261
      C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
      cd08402
      Location:270405
      C2B_Synaptotagmin-1; C2 domain second repeat present in Synaptotagmin 1
    2. XM_006513449.1XP_006513512.1  

      See identical proteins and their annotated locations for XP_006513512.1

      Conserved Domains (2) summary
      cd08385
      Location:139261
      C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
      cd08402
      Location:270405
      C2B_Synaptotagmin-1; C2 domain second repeat present in Synaptotagmin 1
    3. XM_006513446.1XP_006513509.1  

      See identical proteins and their annotated locations for XP_006513509.1

      UniProtKB/Swiss-Prot
      P46096
      UniProtKB/TrEMBL
      H6RXZ1
      Conserved Domains (2) summary
      cd08385
      Location:142264
      C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
      cd08402
      Location:273408
      C2B_Synaptotagmin-1; C2 domain second repeat present in Synaptotagmin 1
    4. XM_017313868.1XP_017169357.1  

      Conserved Domains (2) summary
      cd08385
      Location:139261
      C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
      cd08402
      Location:270405
      C2B_Synaptotagmin-1; C2 domain second repeat present in Synaptotagmin 1
    5. XM_017313866.1XP_017169355.1  

      UniProtKB/Swiss-Prot
      P46096
      UniProtKB/TrEMBL
      H6RXZ1
      Conserved Domains (2) summary
      cd08385
      Location:142264
      C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
      cd08402
      Location:273408
      C2B_Synaptotagmin-1; C2 domain second repeat present in Synaptotagmin 1
    6. XM_006513448.1XP_006513511.1  

      See identical proteins and their annotated locations for XP_006513511.1

      UniProtKB/Swiss-Prot
      P46096
      UniProtKB/TrEMBL
      H6RXZ1
      Conserved Domains (2) summary
      cd08385
      Location:142264
      C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
      cd08402
      Location:273408
      C2B_Synaptotagmin-1; C2 domain second repeat present in Synaptotagmin 1
    7. XM_006513447.1XP_006513510.1  

      See identical proteins and their annotated locations for XP_006513510.1

      UniProtKB/Swiss-Prot
      P46096
      UniProtKB/TrEMBL
      H6RXZ1
      Conserved Domains (2) summary
      cd08385
      Location:142264
      C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
      cd08402
      Location:273408
      C2B_Synaptotagmin-1; C2 domain second repeat present in Synaptotagmin 1
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