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    Stat6 signal transducer and activator of transcription 6 [ Mus musculus (house mouse) ]

    Gene ID: 20852, updated on 14-Oct-2018

    Summary

    Official Symbol
    Stat6provided by MGI
    Official Full Name
    signal transducer and activator of transcription 6provided by MGI
    Primary source
    MGI:MGI:103034
    See related
    Ensembl:ENSMUSG00000002147 Vega:OTTMUSG00000031818
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Expression
    Ubiquitous expression in spleen adult (RPKM 35.4), thymus adult (RPKM 34.3) and 24 other tissues See more
    Orthologs

    Genomic context

    See Stat6 in Genome Data Viewer
    Location:
    10 D3; 10 74.59 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 10 NC_000076.6 (127642039..127660987)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (127080042..127098043)

    Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene low density lipoprotein receptor-related protein 1 Neighboring gene predicted gene, 40802 Neighboring gene uncharacterized LOC105245328 Neighboring gene RIKEN cDNA 1700012D01 gene Neighboring gene Ngfi-A binding protein 2 Neighboring gene predicted gene 16230 Neighboring gene nuclear envelope integral membrane protein 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
     
    DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    RNA polymerase II proximal promoter sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA polymerase II regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
     
    sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    T-helper 1 cell lineage commitment IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cellular response to hydrogen peroxide ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to reactive nitrogen species ISO
    Inferred from Sequence Orthology
    more info
     
    cytokine-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    interleukin-4-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    interleukin-4-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    mammary gland epithelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mammary gland morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of type 2 immune response IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of cold-induced thermogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of isotype switching to IgE isotypes IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    response to cytokine ISO
    Inferred from Sequence Orthology
    more info
     
    signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    signal transducer and transcription activator 6

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009284.2NP_033310.2  signal transducer and transcription activator 6

      See identical proteins and their annotated locations for NP_033310.2

      Status: VALIDATED

      Source sequence(s)
      AK149563, AK163053, BM122652
      Consensus CDS
      CCDS36082.1
      UniProtKB/Swiss-Prot
      P52633
      Related
      ENSMUSP00000089708.5, OTTMUSP00000042008, ENSMUST00000092074.11, OTTMUST00000078897
      Conserved Domains (5) summary
      cd10377
      Location:517646
      SH2_STAT6; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 6 proteins
      pfam01017
      Location:178271
      STAT_alpha; STAT protein, all-alpha domain
      pfam02864
      Location:273526
      STAT_bind; STAT protein, DNA binding domain
      pfam14596
      Location:655837
      STAT6_C; STAT6 C-terminal
      cl03749
      Location:2115
      STAT_int; STAT protein, protein interaction domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000076.6 Reference GRCm38.p4 C57BL/6J

      Range
      127642039..127660987
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_001779497.1 RNA Sequence

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