Format

Send to:

Choose Destination
    • Showing Current items.

    Snap25 synaptosomal-associated protein 25 [ Mus musculus (house mouse) ]

    Gene ID: 20614, updated on 10-Oct-2019

    Summary

    Official Symbol
    Snap25provided by MGI
    Official Full Name
    synaptosomal-associated protein 25provided by MGI
    Primary source
    MGI:MGI:98331
    See related
    Ensembl:ENSMUSG00000027273
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    sp; Bdr; SUP; GENA70; SNAP-25
    Expression
    Biased expression in cerebellum adult (RPKM 622.2), cortex adult (RPKM 577.5) and 3 other tissues See more
    Orthologs

    Genomic context

    See Snap25 in Genome Data Viewer
    Location:
    2 F3; 2 67.56 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    108 current GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (136713439..136782428)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (136539186..136608164)

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32746 Neighboring gene predicted gene, 32659 Neighboring gene ankyrin repeat and EF-hand domain containing 1 Neighboring gene predicted gene, 39943 Neighboring gene predicted gene, 46767

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    SNAP receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    SNARE binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    SNARE binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    calcium-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    ion channel binding ISO
    Inferred from Sequence Orthology
    more info
     
    myosin binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein N-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    syntaxin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    syntaxin-1 binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    syntaxin-1 binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    syntaxin-1 binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    voltage-gated potassium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    SNARE complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    associative learning IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    calcium ion-regulated exocytosis of neurotransmitter ISO
    Inferred from Sequence Orthology
    more info
     
    endosomal transport ISO
    Inferred from Sequence Orthology
    more info
     
    exocytic insertion of neurotransmitter receptor to postsynaptic membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    long-term memory ISO
    Inferred from Sequence Orthology
    more info
     
    long-term synaptic potentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neurotransmitter receptor internalization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neurotransmitter secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of hormone secretion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of synaptic plasticity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of establishment of protein localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of neuron projection development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    short-term synaptic potentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    sleep ISO
    Inferred from Sequence Orthology
    more info
     
    synaptic vesicle exocytosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    synaptic vesicle exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    synaptic vesicle exocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    synaptic vesicle fusion to presynaptic active zone membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    synaptic vesicle priming IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    vesicle fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    colocalizes_with BLOC-1 complex ISO
    Inferred from Sequence Orthology
    more info
     
    SNARE complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    SNARE complex ISO
    Inferred from Sequence Orthology
    more info
     
    actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    anchored component of presynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    axon ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    axonal growth cone ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    endosome ISO
    Inferred from Sequence Orthology
    more info
     
    extrinsic component of cytoplasmic side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    filopodium ISO
    Inferred from Sequence Orthology
    more info
     
    glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    growth cone ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular organelle ISO
    Inferred from Sequence Orthology
    more info
     
    lamellipodium ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    myelin sheath HDA PubMed 
    neuron projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    postsynapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    presynaptic active zone membrane ISO
    Inferred from Sequence Orthology
    more info
     
    presynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    somatodendritic compartment IDA
    Inferred from Direct Assay
    more info
    PubMed 
    synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    synaptic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    synaptobrevin 2-SNAP-25-syntaxin-1a complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex ISO
    Inferred from Sequence Orthology
    more info
     
    trans-Golgi network IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    voltage-gated potassium channel complex ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with voltage-gated potassium channel complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    synaptosomal-associated protein 25
    Names
    blind drunk
    super protein
    synaptosomal-associated 25 kDa protein
    synaptosomal-associated protein, 25 kDa

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001291056.1NP_001277985.1  synaptosomal-associated protein 25 isoform b

      See identical proteins and their annotated locations for NP_001277985.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon but contains a different in-frame exon in the central coding region, compared to variant 1. The encoded isoform (b) is the same length but contains an alternate internal segment, compared to isoform a.
      Source sequence(s)
      AI843805, AL732447, AU080862, BC018249
      Consensus CDS
      CCDS71153.1
      UniProtKB/Swiss-Prot
      P60879
      Related
      ENSMUSP00000105725.3, ENSMUST00000110098.3
      Conserved Domains (3) summary
      cd15885
      Location:143201
      SNARE_SNAP25C; C-terminal SNARE motif of SNAP25
      cd15894
      Location:1082
      SNARE_SNAP25N; N-terminal SNARE motif of SNAP25
      pfam00835
      Location:91141
      SNAP-25; SNAP-25 family
    2. NM_001355254.1NP_001342183.1  synaptosomal-associated protein 25 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 and 3 both encode the same isoform (a).
      Source sequence(s)
      AL732447
      Conserved Domains (3) summary
      cd15885
      Location:143201
      SNARE_SNAP25C; C-terminal SNARE motif of SNAP25
      cd15894
      Location:1082
      SNARE_SNAP25N; N-terminal SNARE motif of SNAP25
      pfam00835
      Location:91141
      SNAP-25; SNAP-25 family
    3. NM_001355255.1NP_001342184.1  synaptosomal-associated protein 25 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate in-frame splice junction and lacks an in-frame exon but contains a different in-frame exon in the central coding region, compared to variant 1. The encoded isoform (d) is the same length but contains an alternate internal segment, compared to isoform a.
      Source sequence(s)
      AL732447
      Conserved Domains (3) summary
      cd15885
      Location:139197
      SNARE_SNAP25C; C-terminal SNARE motif of SNAP25
      cd15894
      Location:1082
      SNARE_SNAP25N; N-terminal SNARE motif of SNAP25
      pfam00835
      Location:91137
      SNAP-25; SNAP-25 family
    4. NM_011428.3NP_035558.1  synaptosomal-associated protein 25 isoform a

      See identical proteins and their annotated locations for NP_035558.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform a. Variants 1 and 3 both encode the same isoform (a).
      Source sequence(s)
      AI843805, AL732447, BC018249, CB232574
      Consensus CDS
      CCDS16793.1
      UniProtKB/Swiss-Prot
      P60879
      Related
      ENSMUSP00000028727.4, ENSMUST00000028727.10
      Conserved Domains (3) summary
      cd15885
      Location:143201
      SNARE_SNAP25C; C-terminal SNARE motif of SNAP25
      cd15894
      Location:1082
      SNARE_SNAP25N; N-terminal SNARE motif of SNAP25
      pfam00835
      Location:91141
      SNAP-25; SNAP-25 family

    RNA

    1. NR_149318.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) uses an alternate splice junction compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AL732447

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p6 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p6 C57BL/6J

      Range
      136713439..136782428
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017316761.2XP_017172250.1  synaptosomal-associated protein 25 isoform X2

      Conserved Domains (3) summary
      cd15885
      Location:80138
      SNARE_SNAP25C; C-terminal SNARE motif of SNAP25
      pfam00835
      Location:2878
      SNAP-25; SNAP-25 family
      cl22856
      Location:119
      SNARE; SNARE motif
    2. XM_017316760.2XP_017172249.1  synaptosomal-associated protein 25 isoform X1

      UniProtKB/Swiss-Prot
      P60879
      Conserved Domains (3) summary
      cd15885
      Location:143201
      SNARE_SNAP25C; C-terminal SNARE motif of SNAP25
      cd15894
      Location:1082
      SNARE_SNAP25N; N-terminal SNARE motif of SNAP25
      pfam00835
      Location:91141
      SNAP-25; SNAP-25 family
    Support Center