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    HIPK1 homeodomain interacting protein kinase 1 [ Homo sapiens (human) ]

    Gene ID: 204851, updated on 19-Jun-2019

    Summary

    Official Symbol
    HIPK1provided by HGNC
    Official Full Name
    homeodomain interacting protein kinase 1provided by HGNC
    Primary source
    HGNC:HGNC:19006
    See related
    Ensembl:ENSG00000163349 MIM:608003
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Myak; Nbak2
    Summary
    The protein encoded by this gene belongs to the Ser/Thr family of protein kinases and HIPK subfamily. It phosphorylates homeodomain transcription factors and may also function as a co-repressor for homeodomain transcription factors. Alternative splicing results in four transcript variants encoding four distinct isoforms. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in bone marrow (RPKM 35.1), testis (RPKM 21.2) and 25 other tissues See more
    Orthologs

    Genomic context

    See HIPK1 in Genome Data Viewer
    Location:
    1p13.2
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (113929324..113977869)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (114471819..114520491)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene adaptor related protein complex 4 subunit beta 1 Neighboring gene DNA cross-link repair 1B Neighboring gene GATA motif-containing MPRA enhancer 196 Neighboring gene HIPK1 antisense RNA 1 Neighboring gene olfactomedin like 3 Neighboring gene ribosomal protein L13a pseudogene 10

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Cardiac conduction, organism-specific biosystem (from REACTOME)
      Cardiac conduction, organism-specific biosystemThe normal sequence of contraction of atria and ventricles of the heart require activation of groups of cardiac cells. The mechanism must elicit rapid changes in heart rate and respond to changes in ...
    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
    • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
      Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...
    • Muscle contraction, organism-specific biosystem (from REACTOME)
      Muscle contraction, organism-specific biosystemIn this module, the processes by which calcium binding triggers actin - myosin interactions and force generation in smooth and striated muscle tissues are annotated.
    • Physiological factors, organism-specific biosystem (from REACTOME)
      Physiological factors, organism-specific biosystemCardiovascular homeostasis can be regulated by natriuretic peptides (Pandey 2014).
    • Regulation of TP53 Activity, organism-specific biosystem (from REACTOME)
      Regulation of TP53 Activity, organism-specific biosystemProtein stability and transcriptional activity of TP53 (p53) tumor suppressor are regulated by post-translational modifications that include ubiquitination, phosphorylation, acetylation, methylation,...
    • Regulation of TP53 Activity through Phosphorylation, organism-specific biosystem (from REACTOME)
      Regulation of TP53 Activity through Phosphorylation, organism-specific biosystemPhosphorylation of TP53 (p53) at the N-terminal serine residues S15 and S20 plays a critical role in protein stabilization as phosphorylation at these sites interferes with binding of the ubiquitin l...
    • Transcriptional Regulation by TP53, organism-specific biosystem (from REACTOME)
      Transcriptional Regulation by TP53, organism-specific biosystemThe tumor suppressor TP53 (encoded by the gene p53) is a transcription factor. Under stress conditions, it recognizes specific responsive DNA elements and thus regulates the transcription of many gen...
    • YAP1- and WWTR1 (TAZ)-stimulated gene expression, organism-specific biosystem (from REACTOME)
      YAP1- and WWTR1 (TAZ)-stimulated gene expression, organism-specific biosystemYAP1 and WWTR1 (TAZ) are transcriptional co-activators, both homologues of the Drosophila Yorkie protein. They both interact with members of the TEAD family of transcription factors, and WWTR1 intera...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA0630, MGC26642, MGC33446, MGC33548

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    adherens junction assembly IEA
    Inferred from Electronic Annotation
    more info
     
    anterior/posterior pattern specification IEA
    Inferred from Electronic Annotation
    more info
     
    definitive hemopoiesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    embryonic camera-type eye morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    embryonic retina morphogenesis in camera-type eye IEA
    Inferred from Electronic Annotation
    more info
     
    endothelial cell apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extrinsic apoptotic signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    eye development ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IEA
    Inferred from Electronic Annotation
    more info
     
    iris morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    lens induction in camera-type eye IEA
    Inferred from Electronic Annotation
    more info
     
    neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    peptidyl-serine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    peptidyl-threonine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of angiogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    positive regulation of cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of signal transduction by p53 class mediator TAS
    Traceable Author Statement
    more info
     
    regulation of tumor necrosis factor-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    retina layer formation IEA
    Inferred from Electronic Annotation
    more info
     
    smoothened signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    smoothened signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    PML body IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    PML body IEA
    Inferred from Electronic Annotation
    more info
     
    centrosome IDA
    Inferred from Direct Assay
    more info
     
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    nuclear speck IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    homeodomain-interacting protein kinase 1
    Names
    homeodomain interacting protein kinase 1-like protein
    nuclear body associated kinase 2b
    nuclear body-associated kinase 2
    NP_001356735.1
    NP_001356736.1
    NP_689909.2
    NP_852003.1
    NP_938009.1
    NP_938010.1
    XP_005270667.2
    XP_005270668.2
    XP_005270670.1
    XP_006710506.2
    XP_011539279.2
    XP_024309676.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001369806.1NP_001356735.1  homeodomain-interacting protein kinase 1 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AL137856, AL731797
      Conserved Domains (1) summary
      cd14228
      Location:174528
      STKc_HIPK1; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 1
    2. NM_001369807.1NP_001356736.1  homeodomain-interacting protein kinase 1 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AL137856, AL731797
    3. NM_152696.4NP_689909.2  homeodomain-interacting protein kinase 1 isoform 2

      See identical proteins and their annotated locations for NP_689909.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has a distinct 3' UTR and coding region, compared to variant 1. This results in a protein (isoform 2) which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AB089957, AL137856, BC033012
      Consensus CDS
      CCDS868.1
      UniProtKB/Swiss-Prot
      Q86Z02
      Related
      ENSP00000358572.4, ENST00000369559.8
      Conserved Domains (2) summary
      smart00220
      Location:190518
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14228
      Location:174528
      STKc_HIPK1; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 1
    4. NM_181358.2NP_852003.1  homeodomain-interacting protein kinase 1 isoform 4

      See identical proteins and their annotated locations for NP_852003.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and lacks one 5' coding exon, compared to variant 1. These differences result in the use of a downstream translation initiation site and a protein (isoform 4) with a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AA995033, AK302726, AL731797, BC033012, BC036057
      Consensus CDS
      CCDS869.1
      UniProtKB/Swiss-Prot
      Q86Z02
      UniProtKB/TrEMBL
      B4DZ33
      Related
      ENSP00000358566.1, ENST00000369553.5
      Conserved Domains (2) summary
      COG0515
      Location:51225
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cl21453
      Location:6134
      PKc_like; Protein Kinases, catalytic domain
    5. NM_198268.3NP_938009.1  homeodomain-interacting protein kinase 1 isoform 1

      See identical proteins and their annotated locations for NP_938009.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AA995033, AK302726, AL137856, AL731797, BC033012
      Consensus CDS
      CCDS867.1
      UniProtKB/Swiss-Prot
      Q86Z02
      UniProtKB/TrEMBL
      B4DZ33
      Related
      ENSP00000407442.3, ENST00000426820.7
      Conserved Domains (1) summary
      cd14228
      Location:174528
      STKc_HIPK1; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 1
    6. NM_198269.2NP_938010.1  homeodomain-interacting protein kinase 1 isoform 3 precursor

      See identical proteins and their annotated locations for NP_938010.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and lacks one 5' coding exon, compared to variant 1. These differences result in the use of a downstream translation initiation site and a protein (isoform 3) with a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AA995033, AK302726, AL731797, BC028408
      Consensus CDS
      CCDS41370.1
      UniProtKB/Swiss-Prot
      Q86Z02
      UniProtKB/TrEMBL
      A0A024R0H9, B4DZ33
      Related
      ENSP00000340956.4, ENST00000340480.8
      Conserved Domains (2) summary
      COG0515
      Location:71245
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cl21453
      Location:1154
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

      Range
      113929324..113977869
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005270610.5XP_005270667.2  homeodomain-interacting protein kinase 1 isoform X1

      Conserved Domains (1) summary
      cd14228
      Location:174528
      STKc_HIPK1; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 1
    2. XM_006710443.4XP_006710506.2  homeodomain-interacting protein kinase 1 isoform X3

      Related
      ENSP00000358574.4, ENST00000369561.8
      Conserved Domains (1) summary
      cd14228
      Location:174528
      STKc_HIPK1; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 1
    3. XM_011540977.3XP_011539279.2  homeodomain-interacting protein kinase 1 isoform X4

      Conserved Domains (1) summary
      cl21453
      Location:174488
      PKc_like; Protein Kinases, catalytic domain
    4. XM_005270611.5XP_005270668.2  homeodomain-interacting protein kinase 1 isoform X2

      Conserved Domains (1) summary
      cd14228
      Location:174528
      STKc_HIPK1; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 1
    5. XM_024453908.1XP_024309676.1  homeodomain-interacting protein kinase 1 isoform X5

      Conserved Domains (1) summary
      cd14228
      Location:174528
      STKc_HIPK1; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 1
    6. XM_005270613.4XP_005270670.1  homeodomain-interacting protein kinase 1 isoform X5

      See identical proteins and their annotated locations for XP_005270670.1

      UniProtKB/Swiss-Prot
      Q86Z02
      Conserved Domains (1) summary
      cd14228
      Location:174528
      STKc_HIPK1; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 1
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