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    EP300 E1A binding protein p300 [ Homo sapiens (human) ]

    Gene ID: 2033, updated on 22-Jan-2023

    Summary

    Official Symbol
    EP300provided by HGNC
    Official Full Name
    E1A binding protein p300provided by HGNC
    Primary source
    HGNC:HGNC:3373
    See related
    Ensembl:ENSG00000100393 MIM:602700; AllianceGenome:HGNC:3373
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    p300; KAT3B; MKHK2; RSTS2
    Summary
    This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in bone marrow (RPKM 27.3), testis (RPKM 17.5) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See EP300 in Genome Data Viewer
    Location:
    22q13.2
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    110 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (41092592..41180077)
    110 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (41567504..41655012)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (41488596..41576081)

    Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene ACTB pseudogene 15 Neighboring gene microRNA 1281 Neighboring gene RNA, U6 small nuclear 375, pseudogene Neighboring gene EP300 antisense RNA 1 Neighboring gene leucine rich repeat containing 37 member A14, pseudogene Neighboring gene uncharacterized LOC646927 Neighboring gene L3MBTL2 antisense RNA 1 Neighboring gene L3MBTL histone methyl-lysine binding protein 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Copy number response

    Description
    Copy number response
    Triplosensitivity

    No evidence available (Last evaluated 2013-03-14)

    ClinGen Genome Curation Page
    Haploinsufficency

    Sufficient evidence for dosage pathogenicity (Last evaluated 2013-03-14)

    ClinGen Genome Curation PagePubMed

    EBI GWAS Catalog

    Description
    A genome-wide association study on a southern European population identifies a new Crohn's disease susceptibility locus at RBX1-EP300.
    EBI GWAS Catalog
    Biological insights from 108 schizophrenia-associated genetic loci.
    EBI GWAS Catalog

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of E1A binding protein p300 (EP300) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 and p300 synergistically increase TGF-beta, ATF-2 and activating protein-1 (AP-1) expression leading to tubular cell apoptosis; in addition, HIV-1 gp120 treatment causes phosphorylation of Smad2 and downregulation of c-Jun PubMed
    env HIV-1 gp120-induced apoptosis in human proximal renal tubular cells is significantly enhanced by p300, and Smad7 and an anti-TGF-beta antibody inhibit this effect of p300 PubMed
    Tat tat HIV-1 Tat interaction with p300 and other histone acetyl transferases is preferentially important for Tat-mediated transactivation of integrated, but not unintegrated, HIV-1 LTR promoter PubMed
    tat Acetylation of HIV-1 Tat by p300 at Lys50 regulates Tat binding to cyclin T1 and HIV-1 TAR RNA, as well as Tat-mediated transactivation of the HIV-1 LTR promoter, by allowing Tat to dissociate from TAR RNA PubMed
    tat HIV-1 Tat is acetylated by p300 on Lys50 and Lys51 PubMed
    tat HIV-1 Tat-induced upregulation and phosphorylation of STAT3 expression results in increased GFAP, Egr-1, and p300 transcription and protein expression in both Tat-expressing astrocytes, and HIV-infected astrocytes PubMed
    tat HIV-1 Tat-induced upregulation of p300 occurs at the transcriptional level through the cis-acting elements of early growth response 1 (egr-1) within its promoter PubMed
    tat HIV-1 Tat, NAP-1, and p300 synergistically activate HIV-1 transcription PubMed
    tat Tat stimulates NF-kappaB-inducing kinase IKKalpha translocation from the cytoplasm to the nucleus in monocytes, which leads to IKKalpha and CBP/p300 recruitment to the IL-10 promoter and histone H3 phosphorylation (Ser 10) and acetylation (Lys 14) PubMed
    tat HIV-1 Tat-mediated upregulation of adenovirus E1a-associated 300 kDa protein p300 regulates increased GFAP expression in astrocytes PubMed
    tat HIV-1 Tat interaction with p300 increases the histone acetyl transferase (HAT) activity of p300 on histone H4, indicating Tat modulates HAT activity of co-activators to derepress the HIV-1 chromatin structure and aid in activated transcription PubMed
    tat HIV-1 Tat forms a ternary complex with p300 and P/CAF PubMed
    tat Binding of HIV-1 Tat to p300 induces a conformational change in the CBP/p300 complex such that it can acquire and bind better to basal transcription factors, indicating Tat helps CBP/p300 recruit new partners to the transcription machinery PubMed
    tat HIV-1 Tat recruits CBP/p300 to the chromosomally integrated HIV-1 LTR promoter PubMed
    tat Acetylation of the p50 subunit of NFkappaB by CBP/p300 is regulated by HIV-1 Tat PubMed
    tat INI-1 and BRG-1 synergize with the p300 acetyltransferase to activate the HIV promoter; this synergism depends on the acetyltransferase activity of p300 and on HIV-1 Tat amino acids Lys(50) and Lys(51), suggesting a regulation of Tat by these proteins PubMed
    tat HIV-1 Tat binds to the minimal histone acetyltransferase domain (amino acids 1253-1710) and E1a binding domain (amino acids 1542-1710) of p300, an effect mediated by the basic domain (amino acids 48-57) of Tat PubMed
    tat HIV-1 Tat induces the polyubiquitination and degradation of Tip60 through p300/CBP-associated E4-type ubiquitin-ligase activity, which results in a dramatic impairment of the Tip60-dependent apoptotic cell response to DNA damage PubMed
    Vpr vpr HIV-1 Vpr and p300/HAT colocalizes with CENP-A and CENP-H proteins in the centromere and arm region of chromosome PubMed
    vpr HIV-1 Vpr actively recruits p300/HAT to a range of chromatine regions including the centromere, resulting in the displacement of HP1-alpha PubMed
    vpr Data suggests that HIV-1 Vpr, Rel A, and p300 act in concert to activate HIV transcription PubMed
    vpr Adenovirus E1A protein represses activation by Vpr by competing for binding to p300, suggesting that p300 is required for activation of HIV transcription by Vpr PubMed
    vpr Transcription Factor IIH (TFIIH) and p300 act cooperatively to enhance Vpr effects on glucocorticoid receptor transactivation PubMed
    vpr The C-terminus of HIV-1 Vpr (amino acids 64-84) mediates the binding of Vpr to p300 (amino acids 2045-2191) PubMed
    vpr HIV-1 Vpr transactivation of HIV transcription and of the glucocorticoid receptor pathway is mediated by direct binding to the p300 co-activator PubMed
    integrase gag-pol The interaction between HIV-1 IN and KAP1 is highly favored by HAT/p300-mediated IN acetylation PubMed
    gag-pol HAT/p300 acetylates lysine's 264, 266, and 273 of HIV-1 IN PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables NF-kappaB binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables STAT family protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables acetyltransferase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    enables acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables acetyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables acyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables beta-catenin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables chromatin DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables chromatin binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables damaged DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables histone H2B acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables histone H3 acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables histone H3K122 acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables histone H4 acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables histone H4 acetyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables histone acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables histone acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables histone acetyltransferase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables histone butyryltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone crotonyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables histone lactyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables lysine N-acetyltransferase activity, acting on acetyl phosphate as donor IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables nuclear androgen receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables nuclear receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables p53 binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables peptide 2-hydroxyisobutyryltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables peptide N-acetyltransferase activity TAS
    Traceable Author Statement
    more info
     
    enables peptide butyryltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables peptide-lysine-N-acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables peptide-lysine-N-acetyltransferase activity TAS
    Traceable Author Statement
    more info
     
    enables pre-mRNA intronic binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein propionyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables tau protein binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transcription coactivator activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables transcription coactivator activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription coactivator activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables transcription coactivator binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription coregulator binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in B cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in N-terminal peptidyl-lysine acetylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in animal organ morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in behavioral defense response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to UV IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in circadian rhythm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in face morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in fat cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in heart development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in histone acetylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in histone acetylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in internal peptidyl-lysine acetylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in internal protein amino acid acetylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in learning or memory IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lung development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in macrophage derived foam cell differentiation IDA
    Inferred from Direct Assay
    more info
     
    involved_in megakaryocyte development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in multicellular organism growth IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of gluconeogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of protein-containing complex assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in nervous system development TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in peptidyl-lysine acetylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in peptidyl-lysine butyrylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in peptidyl-lysine crotonylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in peptidyl-lysine propionylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in platelet formation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation by host of viral transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of DNA-templated transcription TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of NF-kappaB transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of NIK/NF-kappaB signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of neuron projection development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of transforming growth factor beta receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein acetylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein acetylation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in protein destabilization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein stabilization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of androgen receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of autophagy TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of cellular response to heat TAS
    Traceable Author Statement
    more info
     
    involved_in regulation of glycolytic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of mitochondrion organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of signal transduction by p53 class mediator TAS
    Traceable Author Statement
    more info
     
    involved_in regulation of tubulin deacetylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to estrogen IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to hypoxia IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in skeletal muscle tissue development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in somitogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in stimulatory C-type lectin receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    involved_in swimming IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in thigmotaxis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in transcription initiation-coupled chromatin remodeling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    part_of histone acetyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein-DNA complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    part_of transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    histone acetyltransferase p300
    Names
    E1A-associated protein p300
    E1A-binding protein, 300kD
    histone butyryltransferase p300
    histone crotonyltransferase p300
    p300 HAT
    protein 2-hydroxyisobutyryltransferase p300
    protein lactyltransferas p300
    protein propionyltransferase p300
    NP_001349772.1
    NP_001420.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_009817.1 RefSeqGene

      Range
      4983..92468
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_1422

    mRNA and Protein(s)

    1. NM_001362843.2NP_001349772.1  histone acetyltransferase p300 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the central coding region, compared to variant 1, which results in a shorter protein (isoform 2) compared to isoform 1.
      Source sequence(s)
      AL035658, AL080243, AL096765
      Consensus CDS
      CCDS93173.1
      UniProtKB/TrEMBL
      A0A669KB12
      Related
      ENSP00000501078.1, ENST00000674155.1
      Conserved Domains (11) summary
      cd05495
      Location:10251132
      Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...
      smart00551
      Location:17031781
      ZnF_TAZ; TAZ zinc finger, present in p300 and CBP
      cd02337
      Location:16421682
      ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...
      cd15802
      Location:11441216
      RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases
      cd15646
      Location:12171251
      PHD_p300; PHD finger found in histone acetyltransferase p300
      pfam02172
      Location:566646
      KIX; KIX domain
      pfam02135
      Location:347414
      zf-TAZ; TAZ zinc finger
      pfam08214
      Location:12801586
      HAT_KAT11; Histone acetylation protein
      pfam09030
      Location:19792071
      Creb_binding; Creb binding
      pfam09606
      Location:19582382
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cl25526
      Location:9351038
      TonB_N; TonB N-terminal region
    2. NM_001429.4NP_001420.2  histone acetyltransferase p300 isoform 1

      See identical proteins and their annotated locations for NP_001420.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AL035658, AL080243, BC053889, CN278277, CN278282, DB047746, N57495, U01877
      Consensus CDS
      CCDS14010.1
      UniProtKB/Swiss-Prot
      B1AKC2, Q09472
      UniProtKB/TrEMBL
      Q7Z6C1
      Related
      ENSP00000263253.7, ENST00000263253.9
      Conserved Domains (11) summary
      cd05495
      Location:10511158
      Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...
      smart00551
      Location:17291807
      ZnF_TAZ; TAZ zinc finger, present in p300 and CBP
      COG0810
      Location:9611064
      TonB; Periplasmic protein TonB, links inner and outer membranes [Cell wall/membrane/envelope biogenesis]
      cd02337
      Location:16681708
      ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...
      cd15802
      Location:11701242
      RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases
      cd15646
      Location:12431277
      PHD_p300; PHD finger found in histone acetyltransferase p300
      pfam09606
      Location:19842408
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam02135
      Location:347414
      zf-TAZ; TAZ zinc finger
      pfam02172
      Location:566646
      KIX; KIX domain
      pfam08214
      Location:13061517
      HAT_KAT11; Histone acetylation protein
      pfam09030
      Location:20052098
      Creb_binding; Creb binding

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

      Range
      41092592..41180077
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060946.1 Alternate T2T-CHM13v2.0

      Range
      41567504..41655012
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)