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    STK32A serine/threonine kinase 32A [ Homo sapiens (human) ]

    Gene ID: 202374, updated on 17-Jun-2019

    Summary

    Official Symbol
    STK32Aprovided by HGNC
    Official Full Name
    serine/threonine kinase 32Aprovided by HGNC
    Primary source
    HGNC:HGNC:28317
    See related
    Ensembl:ENSG00000169302
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    YANK1
    Expression
    Broad expression in adrenal (RPKM 5.1), thyroid (RPKM 4.8) and 21 other tissues See more
    Orthologs

    Genomic context

    See STK32A in Genome Data Viewer
    Location:
    5q32
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (147234963..147401996)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (146614526..146767418)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene protein phosphatase 2 regulatory subunit Bbeta Neighboring gene uncharacterized LOC105378214 Neighboring gene PPP2R2B intronic transcript 1 Neighboring gene STK32A antisense RNA 1 Neighboring gene dihydropyrimidinase like 3 Neighboring gene JAKMIP2 antisense RNA 1 Neighboring gene uncharacterized LOC101927012 Neighboring gene janus kinase and microtubule interacting protein 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC22688

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    peptidyl-serine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    serine/threonine-protein kinase 32A
    Names
    A930015B13Rik
    CTB-108O6.2
    yet another novel kinase 1
    NP_001106195.1
    NP_001274669.1
    NP_659438.1
    XP_011535878.1
    XP_011535879.1
    XP_011535881.1
    XP_016864702.1
    XP_016864703.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001112724.2NP_001106195.1  serine/threonine-protein kinase 32A isoform 1

      See identical proteins and their annotated locations for NP_001106195.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 3' UTR and coding sequence compared to variant 3. The resulting isoform (1) has a shorter and distinct C-terminus compared to isoform 3.
      Source sequence(s)
      AC009189, BC021666, DA110948, DA231845, DR006392, EB386256
      Consensus CDS
      CCDS47299.1
      UniProtKB/Swiss-Prot
      Q8WU08
      Related
      ENSP00000381030.3, ENST00000397936.8
      Conserved Domains (2) summary
      smart00220
      Location:23270
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05578
      Location:22281
      STKc_Yank1; Catalytic domain of the Serine/Threonine Kinase, Yank1
    2. NM_001287740.2NP_001274669.1  serine/threonine-protein kinase 32A isoform 3

      See identical proteins and their annotated locations for NP_001274669.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3).
      Source sequence(s)
      AC009189, AK315942
      Consensus CDS
      CCDS75351.1
      UniProtKB/TrEMBL
      B7Z9H7
      Related
      ENSP00000381535.3, ENST00000398523.3
      Conserved Domains (1) summary
      cd05578
      Location:22281
      STKc_Yank1; Catalytic domain of the Serine/Threonine Kinase, Yank1
    3. NM_145001.4NP_659438.1  serine/threonine-protein kinase 32A isoform 2

      See identical proteins and their annotated locations for NP_659438.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 3. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 3.
      Source sequence(s)
      AC009189, AC011338
      Consensus CDS
      CCDS54931.1
      UniProtKB/Swiss-Prot
      Q8WU08
      Related
      ENSP00000487441.1, ENST00000626951.2
      Conserved Domains (1) summary
      cl21453
      Location:22157
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

      Range
      147234963..147401996
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011537577.2XP_011535879.1  serine/threonine-protein kinase 32A isoform X2

      Conserved Domains (2) summary
      smart00220
      Location:23270
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05578
      Location:22281
      STKc_Yank1; Catalytic domain of the Serine/Threonine Kinase, Yank1
    2. XM_017009213.1XP_016864702.1  serine/threonine-protein kinase 32A isoform X3

      Related
      ENSP00000497167.1, ENST00000648628.1
    3. XM_011537579.2XP_011535881.1  serine/threonine-protein kinase 32A isoform X5

      See identical proteins and their annotated locations for XP_011535881.1

      Conserved Domains (2) summary
      smart00220
      Location:23220
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05578
      Location:22221
      STKc_Yank1; Catalytic domain of the Serine/Threonine Kinase, Yank1
    4. XM_011537576.1XP_011535878.1  serine/threonine-protein kinase 32A isoform X1

      Conserved Domains (2) summary
      smart00220
      Location:21268
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05578
      Location:20279
      STKc_Yank1; Catalytic domain of the Serine/Threonine Kinase, Yank1
    5. XM_017009214.1XP_016864703.1  serine/threonine-protein kinase 32A isoform X4

    RNA

    1. XR_001742037.1 RNA Sequence

    2. XR_001742038.1 RNA Sequence

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