Rxrb retinoid X receptor beta [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rxrbprovided by MGI
Official Full Name: retinoid X receptor betaprovided by MGI
Primary source: MGI:MGI:98215
See related: Ensembl:ENSMUSG00000039656 AllianceGenome:MGI:98215
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Rub; Nr2b2; RCoR-1; H-2RIIBP
Summary: Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; identical protein binding activity; and nuclear receptor activity. Involved in cellular response to retinoic acid. Acts upstream of or within several processes, including cardiac muscle tissue development; maternal placenta development; and retinoic acid receptor signaling pathway. Predicted to be located in nucleoplasm. Predicted to be part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; genitourinary system; and sensory organ. Orthologous to human RXRB (retinoid X receptor beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in adrenal adult (RPKM 47.1), thymus adult (RPKM 33.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 B1; 17 17.98 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (34250786..34257377)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (34031812..34038403)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Overexpression of retinoid X receptor beta provides protection against oxidized low-density lipoprotein-induced inflammation via regulating PGC1alpha-dependent mitochondrial homeostasis in endothelial cells.
Title: Overexpression of retinoid X receptor beta provides protection against oxidized low-density lipoprotein-induced inflammation via regulating PGC1α-dependent mitochondrial homeostasis in endothelial cells.
Tumor-specific macrophage targeting through recognition of retinoid X receptor beta.
Title: Tumor-specific macrophage targeting through recognition of retinoid X receptor beta.
Role of RXRbeta in platelet function and arterial thrombosis.
Title: Role of RXRβ in platelet function and arterial thrombosis.
the RAR:RXR and LXR:RXR-mediated transcriptional program in embryonic stem cells, neural progenitors and terminally differentiated neurons, is reported.
Title: RXR heterodimers orchestrate transcriptional control of neurogenesis and cell fate specification.
RXRs modulate post-UVR survival of dermal fibroblasts in a "non-cell autonomous" manner, underscoring their role in immune surveillance, while independently mediating post-UVR melanocyte survival in a "cell autonomous" manner
Title: Retinoid-X-receptors (α/β) in melanocytes modulate innate immune responses and differentially regulate cell survival following UV irradiation.
RXRA and RXRB display specific roles in modulating T3-dependent regulation of thyrotropin releasing hormone.
Title: Retinoic X receptor subtypes exert differential effects on the regulation of Trh transcription.
During corpus callosum demyelination, retinoid X receptor beta expression is significantly increased.
Title: Expression of retinoid X receptor β is induced in astrocytes during corpus callosum demyelination.
The expression of dominant-negative RAR (dnRAR) in the forebrain down-regulated the expression of RARbeta, a target gene of RAR/RXR, indicating that dnRAR mice exhibit dysfunction of the RAR/RXR signaling pathway.
Title: Dysfunction of the RAR/RXR signaling pathway in the forebrain impairs hippocampal memory and synaptic plasticity.
Using the light-induced retinal degeneration (LIRD) mouse model, which provides a unique platform for exploring the mechanisms underlying neuritogenesis, we found that retinoid X receptors (RXRs) control neuritogenesis.
Title: Retinoid receptors trigger neuritogenesis in retinal degenerations.
Modulation of RXR-beta in beta-cells may be a new therapeutic approach for improving impaired insulin secretion in type 2 diabetes.
Title: Nuclear hormone retinoid X receptor (RXR) negatively regulates the glucose-stimulated insulin secretion of pancreatic ß-cells.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

MARC_5897-5898:997299407:1 (e-PCR)
- UniSTS:269602

UniSTS:237626 (e-PCR)
- UniSTS:237626

MARC_6301-6302:997299518:1 (e-PCR)
- UniSTS:269632

Rxrb (e-PCR), detects polymorphism
- UniSTS:463429

Rxrb (e-PCR), detects polymorphism
- UniSTS:526981

Rxrb (e-PCR), detects polymorphism
- UniSTS:527531

Rxrb (e-PCR), detects polymorphism
- UniSTS:186541

RH125417 (e-PCR)
- UniSTS:162239

NoName (e-PCR)
- UniSTS:548565

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables chromatin DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nuclear receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear receptor activity	ISO Inferred from Sequence Orthology more info
enables nuclear receptor coactivator activity	ISO Inferred from Sequence Orthology more info
enables nuclear retinoic acid receptor binding	ISO Inferred from Sequence Orthology more info
enables nuclear steroid receptor activity	IEA Inferred from Electronic Annotation more info
enables nuclear thyroid hormone receptor binding	ISO Inferred from Sequence Orthology more info
enables nuclear vitamin D receptor binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables retinoic acid-responsive element binding	IBA Inferred from Biological aspect of Ancestor more info
enables sequence-specific DNA binding	IGI Inferred from Genetic Interaction more info	PubMed
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables transcription cis-regulatory region binding	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in anatomical structure development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cardiac muscle cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to retinoic acid	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within in utero embryonic development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within maternal placenta development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of bone mineralization	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of myelination	ISO Inferred from Sequence Orthology more info
involved_in response to retinoic acid	IBA Inferred from Biological aspect of Ancestor more info
involved_in retinoic acid receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within ventricular cardiac muscle cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within ventricular cardiac muscle cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of RNA polymerase II transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info
part_of RNA polymerase II transcription regulator complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: retinoic acid receptor RXR-beta

Names: MHC class I regulatory element-binding protein H-2RIIBP; nuclear receptor subfamily 2 group B member 2; putative retinoid X receptor beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001205214.1 → NP_001192143.1 retinoic acid receptor RXR-beta isoform 1

See identical proteins and their annotated locations for NP_001192143.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

CR974462

Consensus CDS

CCDS57066.1

UniProtKB/TrEMBL

A0A068BGT5, Q3TWJ1

Related

ENSMUSP00000036585.9, ENSMUST00000044858.16

Conserved Domains (3) summary

cd06943
Location:285 → 502

NR_LBD_RXR_like; The ligand binding domain of the retinoid X receptor and Ultraspiracle, members of nuclear receptor superfamily

cd06956
Location:191 → 266

NR_DBD_RXR; DNA-binding domain of retinoid X receptor (RXR) is composed of two C4-type zinc fingers

pfam11825
Location:122 → 176

Nuc_recep-AF1; Nuclear/hormone receptor activator site AF-1
NM_001205215.1 → NP_001192144.1 retinoic acid receptor RXR-beta isoform 3

See identical proteins and their annotated locations for NP_001192144.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus, compared to isoform 1.

Source sequence(s)

CR974462

Consensus CDS

CCDS57067.1

UniProtKB/TrEMBL

A0A068BES4, Q8VCR0

Related

ENSMUSP00000133661.2, ENSMUST00000173354.9

Conserved Domains (3) summary

cd06943
Location:175 → 392

NR_LBD_RXR_like; The ligand binding domain of the retinoid X receptor and Ultraspiracle, members of nuclear receptor superfamily

cd06956
Location:81 → 156

NR_DBD_RXR; DNA-binding domain of retinoid X receptor (RXR) is composed of two C4-type zinc fingers

pfam11825
Location:12 → 66

Nuc_recep-AF1; Nuclear/hormone receptor activator site AF-1
NM_001205216.1 → NP_001192145.1 retinoic acid receptor RXR-beta isoform 4

See identical proteins and their annotated locations for NP_001192145.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) has multiple differences, compared to variant 1. These differences result in a distinct 5' UTR and cause translation initiation at a downstream start codon, compared to variant 1. The encoded protein (isoform 4) is shorter than isoform 1.

Source sequence(s)

CR974462

Consensus CDS

CCDS57068.1

UniProtKB/TrEMBL

A0A068BES4

Related

ENSMUSP00000112311.3, ENSMUST00000116612.3

Conserved Domains (3) summary

cd06943
Location:175 → 388

NR_LBD_RXR_like; The ligand binding domain of the retinoid X receptor and Ultraspiracle, members of nuclear receptor superfamily

cd06956
Location:81 → 156

NR_DBD_RXR; DNA-binding domain of retinoid X receptor (RXR) is composed of two C4-type zinc fingers

pfam11825
Location:12 → 66

Nuc_recep-AF1; Nuclear/hormone receptor activator site AF-1
NM_011306.4 → NP_035436.1 retinoic acid receptor RXR-beta isoform 2

See identical proteins and their annotated locations for NP_035436.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.

Source sequence(s)

CR974462

Consensus CDS

CCDS89073.1

UniProtKB/Swiss-Prot

P28704, P33243

UniProtKB/TrEMBL

A0A068BGV8

Related

ENSMUSP00000133775.4, ENSMUST00000174299.9

Conserved Domains (3) summary

cd06943
Location:285 → 498

NR_LBD_RXR_like; The ligand binding domain of the retinoid X receptor and Ultraspiracle, members of nuclear receptor superfamily

cd06956
Location:191 → 266

NR_DBD_RXR; DNA-binding domain of retinoid X receptor (RXR) is composed of two C4-type zinc fingers

pfam11825
Location:122 → 176

Nuc_recep-AF1; Nuclear/hormone receptor activator site AF-1