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    Dhrs3 dehydrogenase/reductase (SDR family) member 3 [ Mus musculus (house mouse) ]

    Gene ID: 20148, updated on 5-Jan-2022

    Summary

    Official Symbol
    Dhrs3provided by MGI
    Official Full Name
    dehydrogenase/reductase (SDR family) member 3provided by MGI
    Primary source
    MGI:MGI:1315215
    See related
    Ensembl:ENSMUSG00000066026
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rsdr1; retSDR1
    Summary
    Enables NAD-retinol dehydrogenase activity. Acts upstream of or within several processes, including animal organ morphogenesis; negative regulation of retinoic acid receptor signaling pathway; and regulation of ossification. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in lipid droplet. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and sensory organ. Orthologous to human DHRS3 (dehydrogenase/reductase 3). [provided by Alliance of Genome Resources, Nov 2021]
    Expression
    Broad expression in kidney adult (RPKM 53.4), bladder adult (RPKM 42.8) and 22 other tissues See more
    Orthologs
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    Genomic context

    See Dhrs3 in Genome Data Viewer
    Location:
    4; 4 E1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (144618712..144654779)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (144892534..144928209)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (144482730..144517548)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene peroxiredoxin 2, pseudogene 2 Neighboring gene predicted gene, 46890 Neighboring gene vacuolar protein sorting 13D Neighboring gene predicted gene, 42344 Neighboring gene predicted gene, 36317

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables NAD-retinol dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables NAD-retinol dehydrogenase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables NADP-retinol dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in lipid droplet IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    short-chain dehydrogenase/reductase 3
    Names
    retinal short-chain dehydrogenase/reductase 1
    NP_001165895.1
    NP_001344203.1
    NP_001344204.1
    NP_001344205.1
    NP_001344206.1
    NP_035433.1
    XP_006538744.1
    XP_030109228.1
    XP_036019818.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001172424.2NP_001165895.1  short-chain dehydrogenase/reductase 3 isoform 2

      See identical proteins and their annotated locations for NP_001165895.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) is shorter at the N-terminus and lacks an internal segment compared to isoform 1. Variants 2 and 3 encode the same isoform (2).
      Source sequence(s)
      AA762067, AK032958, AK151419, AL606909
      Consensus CDS
      CCDS51368.1
      UniProtKB/TrEMBL
      G5E8W9
      Related
      ENSMUSP00000126154.2, ENSMUST00000171001.8
      Conserved Domains (1) summary
      cd05339
      Location:27255
      17beta-HSDXI-like_SDR_c; human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs
    2. NM_001357274.1NP_001344203.1  short-chain dehydrogenase/reductase 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AA762067, AK032958, AK151419, AL606909
      Consensus CDS
      CCDS51368.1
      Conserved Domains (1) summary
      cd05339
      Location:27255
      17beta-HSDXI-like_SDR_c; human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs
    3. NM_001357275.1NP_001344204.1  short-chain dehydrogenase/reductase 3 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AK032958, AK151419, AL606909
      Conserved Domains (1) summary
      cd05339
      Location:48216
      17beta-HSDXI-like_SDR_c; human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs
    4. NM_001357276.1NP_001344205.1  short-chain dehydrogenase/reductase 3 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AK032958, AK087137, AL606909
      Conserved Domains (1) summary
      cd05339
      Location:48216
      17beta-HSDXI-like_SDR_c; human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs
    5. NM_001357277.1NP_001344206.1  short-chain dehydrogenase/reductase 3 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AK032958, AK151419, AL606909
      Conserved Domains (1) summary
      cd05339
      Location:1196
      17beta-HSDXI-like_SDR_c; human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs
    6. NM_011303.7NP_035433.1  short-chain dehydrogenase/reductase 3 isoform 1

      See identical proteins and their annotated locations for NP_035433.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AK032958, AK151419, AL606909
      Consensus CDS
      CCDS18912.1
      UniProtKB/Swiss-Prot
      O88876
      Related
      ENSMUSP00000122552.2, ENSMUST00000154208.8
      Conserved Domains (2) summary
      cd05339
      Location:53281
      17beta-HSDXI-like_SDR_c; human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs
      PRK09072
      Location:35288
      PRK09072; short chain dehydrogenase; Provisional

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      144618712..144654779
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030253368.2XP_030109228.1  short-chain dehydrogenase/reductase 3 isoform X2

      Conserved Domains (1) summary
      cd05339
      Location:48216
      17beta-HSDXI-like_SDR_c; human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs
    2. XM_006538681.5XP_006538744.1  short-chain dehydrogenase/reductase 3 isoform X2

      See identical proteins and their annotated locations for XP_006538744.1

      Conserved Domains (1) summary
      cd05339
      Location:48216
      17beta-HSDXI-like_SDR_c; human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs
    3. XM_036163925.1XP_036019818.1  short-chain dehydrogenase/reductase 3 isoform X1

      Conserved Domains (1) summary
      cd05339
      Location:53233
      17beta-HSDXI-like_SDR_c; human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs
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