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    EMP3 epithelial membrane protein 3 [ Homo sapiens (human) ]

    Gene ID: 2014, updated on 15-Jun-2019

    Summary

    Official Symbol
    EMP3provided by HGNC
    Official Full Name
    epithelial membrane protein 3provided by HGNC
    Primary source
    HGNC:HGNC:3335
    See related
    Ensembl:ENSG00000142227 MIM:602335
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    YMP
    Summary
    The protein encoded by this gene belongs to the PMP-22/EMP/MP20 family of proteins. The protein contains four transmembrane domains and two N-linked glycosylation sites. It is thought to be involved in cell proliferation, cell-cell interactions and function as a tumor suppressor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
    Expression
    Ubiquitous expression in bone marrow (RPKM 63.7), appendix (RPKM 40.0) and 24 other tissues See more
    Orthologs

    Genomic context

    See EMP3 in Genome Data Viewer
    Location:
    19q13.33
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (48325372..48330554)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (48828629..48833810)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ZNF114 antisense RNA 1 Neighboring gene zinc finger protein 114 Neighboring gene coiled-coil domain containing 114 Neighboring gene Sharpr-MPRA regulatory region 73 Neighboring gene transmembrane protein 143 Neighboring gene synaptogyrin 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    bleb assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell death IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    epithelial membrane protein 3
    Names
    EMP-3
    HNMP-1
    hematopoietic neural membrane protein 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001313905.1NP_001300834.1  epithelial membrane protein 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC008392
      Consensus CDS
      CCDS12715.1
      UniProtKB/Swiss-Prot
      P54852
      UniProtKB/TrEMBL
      A0A024QZF8
      Conserved Domains (1) summary
      pfam00822
      Location:20156
      PMP22_Claudin; PMP-22/EMP/MP20/Claudin family
    2. NM_001425.3NP_001416.1  epithelial membrane protein 3

      See identical proteins and their annotated locations for NP_001416.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AL541088, BC009718
      Consensus CDS
      CCDS12715.1
      UniProtKB/Swiss-Prot
      P54852
      UniProtKB/TrEMBL
      A0A024QZF8
      Related
      ENSP00000270221.5, ENST00000270221.11
      Conserved Domains (1) summary
      pfam00822
      Location:20156
      PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

      Range
      48325504..48330554
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011526605.3XP_011524907.1  epithelial membrane protein 3 isoform X1

      See identical proteins and their annotated locations for XP_011524907.1

      UniProtKB/Swiss-Prot
      P54852
      UniProtKB/TrEMBL
      A0A024QZF8
      Related
      ENSP00000469194.1, ENST00000597279.5
      Conserved Domains (1) summary
      pfam00822
      Location:20156
      PMP22_Claudin; PMP-22/EMP/MP20/Claudin family
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