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    LRRC45 leucine rich repeat containing 45 [ Homo sapiens (human) ]

    Gene ID: 201255, updated on 27-Nov-2024

    Summary

    Official Symbol
    LRRC45provided by HGNC
    Official Full Name
    leucine rich repeat containing 45provided by HGNC
    Primary source
    HGNC:HGNC:28302
    See related
    Ensembl:ENSG00000169683 AllianceGenome:HGNC:28302
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Located in several cellular components, including centrosome; cytosol; and nucleoplasm. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in colon (RPKM 3.3), bone marrow (RPKM 3.0) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See LRRC45 in Genome Data Viewer
    Location:
    17q25.3
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (82023305..82031151)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (82890464..82898310)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (79981181..79989027)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:79934891-79935662 Neighboring gene ASPSCR1 tether for SLC2A4, UBX domain containing Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:79947643-79948352 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:79949063-79949770 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:79951899-79952606 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:79958937-79959584 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:79961033-79961554 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:79961555-79962076 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:79962077-79962598 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:79963388-79963894 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:79966024-79966524 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:79972873-79973594 Neighboring gene Sharpr-MPRA regulatory region 10297 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:79974318-79975039 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:79979009-79979681 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:79981231-79982154 Neighboring gene centromere protein X Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:79987649-79988172 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9180 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9181 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9182 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9183 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9184 Neighboring gene Rac family small GTPase 3 Neighboring gene dicarbonyl and L-xylulose reductase

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC20806

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    leucine-rich repeat-containing protein 45

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_144999.4NP_659436.1  leucine-rich repeat-containing protein 45

      See identical proteins and their annotated locations for NP_659436.1

      Status: VALIDATED

      Source sequence(s)
      AC137723, BC014109, BI837975
      Consensus CDS
      CCDS11797.1
      UniProtKB/Swiss-Prot
      Q96CN5
      Related
      ENSP00000306760.3, ENST00000306688.8
      Conserved Domains (3) summary
      sd00033
      Location:6184
      LRR_RI; leucine-rich repeat [structural motif]
      cl25732
      Location:267634
      SMC_N; RecF/RecN/SMC N terminal domain
      cl26161
      Location:34224
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      82023305..82031151
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047435564.1XP_047291520.1  leucine-rich repeat-containing protein 45 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      82890464..82898310
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054315369.1XP_054171344.1  leucine-rich repeat-containing protein 45 isoform X1