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    DHRS7C dehydrogenase/reductase 7C [ Homo sapiens (human) ]

    Gene ID: 201140, updated on 17-Jun-2019

    Summary

    Official Symbol
    DHRS7Cprovided by HGNC
    Official Full Name
    dehydrogenase/reductase 7Cprovided by HGNC
    Primary source
    HGNC:HGNC:32423
    See related
    Ensembl:ENSG00000184544 MIM:616161
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SDR32C2
    Expression
    Restricted expression toward heart (RPKM 31.7) See more
    Orthologs

    Genomic context

    See DHRS7C in Genome Data Viewer
    Location:
    17p13.1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (9771438..9791592, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (9674751..9694894, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene cilia and flagella associated protein 52 Neighboring gene ribosomal protein L19 pseudogene 18 Neighboring gene uncharacterized LOC107985011 Neighboring gene ubiquitin specific peptidase 43 Neighboring gene DHRS7C intron CAGE-defined high expression enhancer Neighboring gene GSG1 like 2 Neighboring gene glucagon like peptide 2 receptor Neighboring gene nucleophosmin 1 pseudogene 45

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Potential readthrough

    Included gene: GSG1L2

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    retinol dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    longitudinal sarcoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    sarcoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    dehydrogenase/reductase SDR family member 7C
    Names
    dehydrogenase/reductase (SDR family) member 7C
    short-chain dehydrogenase/reductase family 32C member 2
    NP_001099041.1
    NP_001207422.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105571.3NP_001099041.1  dehydrogenase/reductase SDR family member 7C isoform 2 precursor

      See identical proteins and their annotated locations for NP_001099041.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AC027045, AI091419, AI168267, BC147024
      Consensus CDS
      CCDS58517.1
      UniProtKB/Swiss-Prot
      A6NNS2
      Related
      ENSP00000459579.1, ENST00000571134.1
      Conserved Domains (1) summary
      cd05332
      Location:35296
      11beta-HSD1_like_SDR_c; 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs
    2. NM_001220493.2NP_001207422.1  dehydrogenase/reductase SDR family member 7C isoform 1 precursor

      See identical proteins and their annotated locations for NP_001207422.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC027045, AI091419, AI168267, BC171909
      Consensus CDS
      CCDS56020.1
      UniProtKB/Swiss-Prot
      A6NNS2
      Related
      ENSP00000327975.4, ENST00000330255.9
      Conserved Domains (1) summary
      cd05332
      Location:35297
      11beta-HSD1_like_SDR_c; 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

      Range
      9771438..9791592 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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