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    TXLNA taxilin alpha [ Homo sapiens (human) ]

    Gene ID: 200081, updated on 5-May-2024

    Summary

    Official Symbol
    TXLNAprovided by HGNC
    Official Full Name
    taxilin alphaprovided by HGNC
    Primary source
    HGNC:HGNC:30685
    See related
    Ensembl:ENSG00000084652 MIM:608676; AllianceGenome:HGNC:30685
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IL14; TXLN; IL-14
    Summary
    Predicted to enable syntaxin binding activity. Predicted to be involved in exocytosis. Predicted to act upstream of or within B cell activation. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis (RPKM 17.8), skin (RPKM 14.9) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See TXLNA in Genome Data Viewer
    Location:
    1p35.2
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (32179675..32198285)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (32037572..32056187)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (32645276..32663886)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene transmembrane protein 39B Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:32557367-32557892 Neighboring gene microRNA 5585 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:32573351-32573869 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:32573870-32574387 Neighboring gene Sharpr-MPRA regulatory region 5670 Neighboring gene karyopherin subunit alpha 6 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:32644454-32645213 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:32645214-32645972 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 671 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 670 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:32664855-32665413 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:32665414-32665971 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 672 Neighboring gene H3K4me1 hESC enhancers GRCh37_chr1:32666522-32667041 and GRCh37_chr1:32667042-32667562 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:32670259-32670760 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 675 Neighboring gene coiled-coil domain containing 28B Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:32681346-32682545 Neighboring gene doublecortin domain containing 2B Neighboring gene IQ motif containing C Neighboring gene transmembrane protein 234

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC118870, MGC118871, DKFZp451J0118

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables syntaxin binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in B cell activation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in exocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in extracellular region NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in membrane HDA PubMed 

    General protein information

    Preferred Names
    alpha-taxilin
    Names
    interleukin 14

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001376857.1NP_001363786.1  alpha-taxilin isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL049795
      Consensus CDS
      CCDS353.1
      UniProtKB/Swiss-Prot
      D3DPP6, P40222, Q5TFJ6, Q66K62, Q86T54, Q86T85, Q86T86, Q86Y86, Q86YW3, Q8N2Y3
      Related
      ENSP00000362711.1, ENST00000373609.1
      Conserved Domains (2) summary
      PRK07764
      Location:9161
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      pfam09728
      Location:172477
      Taxilin; Myosin-like coiled-coil protein
    2. NM_001376858.1NP_001363787.1  alpha-taxilin isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL049795
      Conserved Domains (1) summary
      pfam09728
      Location:1302
      Taxilin; Myosin-like coiled-coil protein
    3. NM_001376859.1NP_001363788.1  alpha-taxilin isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL049795
      Conserved Domains (1) summary
      pfam09728
      Location:1302
      Taxilin; Myosin-like coiled-coil protein
    4. NM_175852.4NP_787048.1  alpha-taxilin isoform 1

      See identical proteins and their annotated locations for NP_787048.1

      Status: VALIDATED

      Source sequence(s)
      AL049795, AL832338, BC029686, BC046565
      Consensus CDS
      CCDS353.1
      UniProtKB/Swiss-Prot
      D3DPP6, P40222, Q5TFJ6, Q66K62, Q86T54, Q86T85, Q86T86, Q86Y86, Q86YW3, Q8N2Y3
      Related
      ENSP00000362712.3, ENST00000373610.8
      Conserved Domains (2) summary
      PRK07764
      Location:9161
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      pfam09728
      Location:172477
      Taxilin; Myosin-like coiled-coil protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      32179675..32198285
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017000563.2XP_016856052.1  alpha-taxilin isoform X1

    2. XM_011540932.3XP_011539234.1  alpha-taxilin isoform X2

      See identical proteins and their annotated locations for XP_011539234.1

      Conserved Domains (1) summary
      pfam09728
      Location:40318
      Taxilin; Myosin-like coiled-coil protein
    3. XM_017000561.2XP_016856050.1  alpha-taxilin isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      32037572..32056187
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054334933.1XP_054190908.1  alpha-taxilin isoform X1

    2. XM_054334934.1XP_054190909.1  alpha-taxilin isoform X2

    3. XM_054334932.1XP_054190907.1  alpha-taxilin isoform X1