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    Rph3a rabphilin 3A [ Mus musculus (house mouse) ]

    Gene ID: 19894, updated on 2-Jun-2019

    Summary

    Official Symbol
    Rph3aprovided by MGI
    Official Full Name
    rabphilin 3Aprovided by MGI
    Primary source
    MGI:MGI:102788
    See related
    Ensembl:ENSMUSG00000029608
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AU022689; AW108370; 2900002P20Rik
    Expression
    Biased expression in cerebellum adult (RPKM 64.9), cortex adult (RPKM 57.6) and 4 other tissues See more
    Orthologs

    Genomic context

    See Rph3a in Genome Data Viewer
    Location:
    5; 5 F
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (120940499..121010103, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (121390508..121459527, complement)

    Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene 2'-5' oligoadenylate synthetase 1A Neighboring gene 2'-5' oligoadenylate synthetase 1 pseudogene Neighboring gene 2'-5' oligoadenylate synthetase 1D Neighboring gene predicted gene, 32185 Neighboring gene protein tyrosine phosphatase, non-receptor type 11 Neighboring gene ribosomal protein L6

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    Rab GTPase binding IEA
    Inferred from Electronic Annotation
    more info
     
    calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    calcium-dependent phospholipid binding ISO
    Inferred from Sequence Orthology
    more info
     
    inositol 1,4,5 trisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
     
    lipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    phosphate ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    phosphatidylinositol-4,5-bisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    selenium binding ISO
    Inferred from Sequence Orthology
    more info
     
    zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    dendritic spine organization ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of NMDA receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    spontaneous neurotransmitter secretion IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    colocalizes_with Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    cholinergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    dendritic spine ISO
    Inferred from Sequence Orthology
    more info
     
    extrinsic component of membrane ISO
    Inferred from Sequence Orthology
    more info
     
    extrinsic component of synaptic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    neuromuscular junction ISO
    Inferred from Sequence Orthology
    more info
     
    neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    secretory granule ISO
    Inferred from Sequence Orthology
    more info
     
    synapse ISO
    Inferred from Sequence Orthology
    more info
     
    synaptic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    synaptic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    rabphilin-3A
    Names
    Doc2 family
    exophilin-1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001302344.1NP_001289273.1  rabphilin-3A

      See identical proteins and their annotated locations for NP_001289273.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC015535, BC050883, CB526789
      Consensus CDS
      CCDS39246.1
      UniProtKB/Swiss-Prot
      P47708
      Related
      ENSMUSP00000143917.1, ENSMUST00000202406.3
      Conserved Domains (3) summary
      cd04035
      Location:380503
      C2A_Rabphilin_Doc2; C2 domain first repeat present in Rabphilin and Double C2 domain
      cd08384
      Location:540672
      C2B_Rabphilin_Doc2; C2 domain second repeat present in Rabphilin and Double C2 domain
      cd15762
      Location:88168
      FYVE_RP3A; FYVE-related domain found in rabphilin-3A and similar proteins
    2. NM_001302345.1NP_001289274.1  rabphilin-3A

      See identical proteins and their annotated locations for NP_001289274.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC015535, AK139040, BC042585
      Consensus CDS
      CCDS39246.1
      UniProtKB/Swiss-Prot
      P47708
      Related
      ENSMUSP00000144291.1, ENSMUST00000202326.3
      Conserved Domains (3) summary
      cd04035
      Location:380503
      C2A_Rabphilin_Doc2; C2 domain first repeat present in Rabphilin and Double C2 domain
      cd08384
      Location:540672
      C2B_Rabphilin_Doc2; C2 domain second repeat present in Rabphilin and Double C2 domain
      cd15762
      Location:88168
      FYVE_RP3A; FYVE-related domain found in rabphilin-3A and similar proteins
    3. NM_011286.3NP_035416.1  rabphilin-3A

      See identical proteins and their annotated locations for NP_035416.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AU067470, BC042585
      Consensus CDS
      CCDS39246.1
      UniProtKB/Swiss-Prot
      P47708
      Related
      ENSMUSP00000078198.5, ENSMUST00000079204.8
      Conserved Domains (3) summary
      cd04035
      Location:380503
      C2A_Rabphilin_Doc2; C2 domain first repeat present in Rabphilin and Double C2 domain
      cd08384
      Location:540672
      C2B_Rabphilin_Doc2; C2 domain second repeat present in Rabphilin and Double C2 domain
      cd15762
      Location:88168
      FYVE_RP3A; FYVE-related domain found in rabphilin-3A and similar proteins

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

      Range
      120940499..121010103 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011248186.2XP_011246488.1  rabphilin-3A isoform X1

      See identical proteins and their annotated locations for XP_011246488.1

      Conserved Domains (3) summary
      cd04035
      Location:383506
      C2A_Rabphilin_Doc2; C2 domain first repeat present in Rabphilin and Double C2 domain
      cd08384
      Location:543675
      C2B_Rabphilin_Doc2; C2 domain second repeat present in Rabphilin and Double C2 domain
      cd15762
      Location:88168
      FYVE_RP3A; FYVE-related domain found in rabphilin-3A and similar proteins
    2. XM_011248188.2XP_011246490.1  rabphilin-3A isoform X2

      Conserved Domains (3) summary
      cd04035
      Location:379502
      C2A_Rabphilin_Doc2; C2 domain first repeat present in Rabphilin and Double C2 domain
      cd08384
      Location:539671
      C2B_Rabphilin_Doc2; C2 domain second repeat present in Rabphilin and Double C2 domain
      cd15762
      Location:84164
      FYVE_RP3A; FYVE-related domain found in rabphilin-3A and similar proteins
    3. XM_011248185.2XP_011246487.1  rabphilin-3A isoform X1

      See identical proteins and their annotated locations for XP_011246487.1

      Conserved Domains (3) summary
      cd04035
      Location:383506
      C2A_Rabphilin_Doc2; C2 domain first repeat present in Rabphilin and Double C2 domain
      cd08384
      Location:543675
      C2B_Rabphilin_Doc2; C2 domain second repeat present in Rabphilin and Double C2 domain
      cd15762
      Location:88168
      FYVE_RP3A; FYVE-related domain found in rabphilin-3A and similar proteins
    4. XM_011248187.2XP_011246489.1  rabphilin-3A isoform X1

      See identical proteins and their annotated locations for XP_011246489.1

      Conserved Domains (3) summary
      cd04035
      Location:383506
      C2A_Rabphilin_Doc2; C2 domain first repeat present in Rabphilin and Double C2 domain
      cd08384
      Location:543675
      C2B_Rabphilin_Doc2; C2 domain second repeat present in Rabphilin and Double C2 domain
      cd15762
      Location:88168
      FYVE_RP3A; FYVE-related domain found in rabphilin-3A and similar proteins
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