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    EIF4A2 eukaryotic translation initiation factor 4A2 [ Homo sapiens (human) ]

    Gene ID: 1974, updated on 15-Jun-2019

    Summary

    Official Symbol
    EIF4A2provided by HGNC
    Official Full Name
    eukaryotic translation initiation factor 4A2provided by HGNC
    Primary source
    HGNC:HGNC:3284
    See related
    Ensembl:ENSG00000156976 MIM:601102
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DDX2B; EIF4A; EIF4F; BM-010; eIF4A-II; eIF-4A-II
    Expression
    Ubiquitous expression in ovary (RPKM 426.9), brain (RPKM 313.7) and 25 other tissues See more
    Orthologs

    Genomic context

    See EIF4A2 in Genome Data Viewer
    Location:
    3q27.3
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 3 NC_000003.12 (186783572..186789897)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (186501361..186507686)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 1105, pseudogene Neighboring gene G protein pathway suppressor 2 pseudogene 2 Neighboring gene small nucleolar RNA, H/ACA box 63B Neighboring gene small nucleolar RNA, C/D box 2 Neighboring gene microRNA 1248 Neighboring gene small nucleolar RNA, H/ACA box 81 Neighboring gene small nucleolar RNA, H/ACA box 63 Neighboring gene small nucleolar RNA, H/ACA box 4 Neighboring gene replication factor C subunit 4 Neighboring gene long intergenic non-protein coding RNA 2043 Neighboring gene adiponectin enhancer region Neighboring gene adiponectin, C1Q and collagen domain containing Neighboring gene ADIPOQ antisense RNA 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    A meta-analysis of genome-wide association studies for adiponectin levels in East Asians identifies a novel locus near WDR11-FGFR2.
    NHGRI GWA Catalog

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of eukaryotic translation initiation factor 4A2 (EIF4A2) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag Expression of HIV-1 Gag requires eIF4E, eIF4G, and eIF4A (eIF4F) binding to the viral 5'UTR PubMed
    retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human eukaryotic translation initiation factor 4A2 (EIF4A2) at amino acid residues 375-376 by the HIV-1 protease PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    • Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, organism-specific biosystem (from REACTOME)
      Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, organism-specific biosystemThe cap-binding complex is constituted by the initiation factors eIF4A, eIF4G and eIF4E. First, eIF4E must be released from the inactive eIF4E:4E-BP complex. Then eIF4A interacts with eIF4G, and eIF...
    • Antiviral mechanism by IFN-stimulated genes, organism-specific biosystem (from REACTOME)
      Antiviral mechanism by IFN-stimulated genes, organism-specific biosystemThe ISG proteins generated by IFN pathways plays key roles in the induction of innate and adaptive immune responses.
    • Cap-dependent Translation Initiation, organism-specific biosystem (from REACTOME)
      Cap-dependent Translation Initiation, organism-specific biosystemTranslation initiation is a complex process in which the Met-tRNAi initiator, 40S, and 60S ribosomal subunits are assembled by eukaryotic initiation factors (eIFs) into an 80S ribosome at the start c...
    • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
      Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
    • Deadenylation of mRNA, organism-specific biosystem (from REACTOME)
      Deadenylation of mRNA, organism-specific biosystemDeadenylation of mRNA proceeds in two steps. According to current models, in the first step the poly(A) tail is shortened from about 200 adenosine residues to about 80 residues by the PAN2-PAN3 compl...
    • Deadenylation-dependent mRNA decay, organism-specific biosystem (from REACTOME)
      Deadenylation-dependent mRNA decay, organism-specific biosystemAfter undergoing rounds of translation, mRNA is normally destroyed by the deadenylation-dependent pathway. Though the trigger is unclear, deadenylation likely proceeds in two steps: one catalyzed by...
    • Eukaryotic Translation Initiation, organism-specific biosystem (from REACTOME)
      Eukaryotic Translation Initiation, organism-specific biosystemInitiation of translation in the majority of eukaryotic cellular mRNAs depends on the 5'-cap (m7GpppN) and involves ribosomal scanning of the 5' untranslated region (5'-UTR) for an initiating AUG sta...
    • GTP hydrolysis and joining of the 60S ribosomal subunit, organism-specific biosystem (from REACTOME)
      GTP hydrolysis and joining of the 60S ribosomal subunit, organism-specific biosystemHydrolysis of eIF2-GTP occurs after the Met-tRNAi has recognized the AUG. This reaction is catalyzed by eIF5 (or eIF5B) and is thought to cause dissociation of all other initiation factors and allow ...
    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
    • ISG15 antiviral mechanism, organism-specific biosystem (from REACTOME)
      ISG15 antiviral mechanism, organism-specific biosystemInterferon-stimulated gene 15 (ISG15) is a member of the ubiquitin-like (Ubl) family. It is strongly induced upon exposure to type I Interferons (IFNs), viruses, bacterial LPS, and other stresses. On...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Interferon Signaling, organism-specific biosystem (from REACTOME)
      Interferon Signaling, organism-specific biosystemInterferons (IFNs) are cytokines that play a central role in initiating immune responses, especially antiviral and antitumor effects. There are three types of IFNs:Type I (IFN-alpha, -beta and others...
    • L13a-mediated translational silencing of Ceruloplasmin expression, organism-specific biosystem (from REACTOME)
      L13a-mediated translational silencing of Ceruloplasmin expression, organism-specific biosystemWhile circularization of mRNA during translation initiation is thought to contribute to an increase in the efficiency of translation, it also appears to provide a mechanism for translational silencin...
    • Metabolism of proteins, organism-specific biosystem (from REACTOME)
      Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
    • RNA transport, organism-specific biosystem (from KEGG)
      RNA transport, organism-specific biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
    • RNA transport, conserved biosystem (from KEGG)
      RNA transport, conserved biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
    • Ribosomal scanning and start codon recognition, organism-specific biosystem (from REACTOME)
      Ribosomal scanning and start codon recognition, organism-specific biosystemThe 80S ribosome bound to the mRNA moves along the mRNA molecule from its initial site to the initiation codon and forms a 48S complex, in which the initiation codon is base paired to the anticodon o...
    • Translation, organism-specific biosystem (from REACTOME)
      Translation, organism-specific biosystemProtein synthesis is accomplished through the process of translation of an mRNA sequence into a polypeptide chain. This process can be divided into three distinct stages: initiation, elongation and ...
    • Translation Factors, organism-specific biosystem (from WikiPathways)
      Translation Factors, organism-specific biosystemProtein synthesis is the ultimate step of gene expression and a key control point for regulation. In particular, it enables cells to rapidly manipulate protein production without new mRNA synthesis, ...
    • Translation initiation complex formation, organism-specific biosystem (from REACTOME)
      Translation initiation complex formation, organism-specific biosystemThe translation initiation complex forms when the 43S complex binds the mRNA that is associated with eIF4F, eIF4B and eIF4H. eIF4G in the eIF4F complex can directly contact eIF3 in the 43S complex. e...
    • eIF4F complex, organism-specific biosystem (from KEGG)
      eIF4F complex, organism-specific biosystemStructural complex; Genetic information processing; RNA processing
    • eIF4F complex, conserved biosystem (from KEGG)
      eIF4F complex, conserved biosystemStructural complex; Genetic information processing; RNA processing

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    ATPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA binding HDA PubMed 
    RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    RNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    RNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    helicase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    translation initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cellular response to leukemia inhibitory factor IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasmic translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of RNA-directed 5'-3' RNA polymerase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of translational initiation TAS
    Traceable Author Statement
    more info
    PubMed 
    translational initiation TAS
    Traceable Author Statement
    more info
     
    viral process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasmic stress granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    eukaryotic translation initiation factor 4F complex TAS
    Traceable Author Statement
    more info
    PubMed 
    perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    eukaryotic initiation factor 4A-II
    Names
    ATP-dependent RNA helicase eIF4A-2
    NP_001958.2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001967.4NP_001958.2  eukaryotic initiation factor 4A-II

      See identical proteins and their annotated locations for NP_001958.2

      Status: VALIDATED

      Source sequence(s)
      AL556981, BC013708, BC015842, D30655
      Consensus CDS
      CCDS3282.1
      UniProtKB/Swiss-Prot
      Q14240
      Related
      ENSP00000326381.5, ENST00000323963.10
      Conserved Domains (1) summary
      PTZ00424
      Location:21407
      PTZ00424; helicase 45; Provisional

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

      Range
      186783577..186789897
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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