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    METTL21C methyltransferase like 21C [ Homo sapiens (human) ]

    Gene ID: 196541, updated on 17-Jun-2019

    Summary

    Official Symbol
    METTL21Cprovided by HGNC
    Official Full Name
    methyltransferase like 21Cprovided by HGNC
    Primary source
    HGNC:HGNC:33717
    See related
    Ensembl:ENSG00000139780 MIM:615259
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C13orf39
    Expression
    Low expression observed in reference dataset See more
    Orthologs

    Genomic context

    See METTL21C in Genome Data Viewer
    Location:
    13q33.1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 13 NC_000013.11 (102678782..102704311, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (103338097..103346871, complement)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene fibroblast growth factor 14 Neighboring gene FGF14 antisense RNA 2 Neighboring gene uncharacterized LOC107984588 Neighboring gene tripeptidyl peptidase 2 Neighboring gene uncharacterized LOC105370337 Neighboring gene coiled-coil domain containing 168 Neighboring gene testis expressed 30

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    heat shock protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein-lysine N-methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    cellular response to dexamethasone stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    hormone-mediated apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    peptidyl-lysine methylation IEA
    Inferred from Electronic Annotation
    more info
     
    protein methylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    skeletal muscle tissue development IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    protein-lysine methyltransferase METTL21C
    Names
    methyltransferase-like protein 21C

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001010977.2NP_001010977.1  protein-lysine methyltransferase METTL21C

      See identical proteins and their annotated locations for NP_001010977.1

      Status: VALIDATED

      Source sequence(s)
      BC132750, BX089441
      Consensus CDS
      CCDS32003.1
      UniProtKB/Swiss-Prot
      Q5VZV1
      Related
      ENSP00000267273.5, ENST00000267273.6
      Conserved Domains (1) summary
      cl17173
      Location:73239
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p13 Primary Assembly

      Range
      102678782..102704311 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017020408.2XP_016875897.1  protein-lysine methyltransferase METTL21C isoform X1

      UniProtKB/Swiss-Prot
      Q5VZV1
      Conserved Domains (1) summary
      cl17173
      Location:73239
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    2. XM_017020407.2XP_016875896.1  protein-lysine methyltransferase METTL21C isoform X1

      UniProtKB/Swiss-Prot
      Q5VZV1
      Conserved Domains (1) summary
      cl17173
      Location:73239
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
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