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    EGR3 early growth response 3 [ Homo sapiens (human) ]

    Gene ID: 1960, updated on 17-Jun-2019

    Summary

    Official Symbol
    EGR3provided by HGNC
    Official Full Name
    early growth response 3provided by HGNC
    Primary source
    HGNC:HGNC:3240
    See related
    Ensembl:ENSG00000179388 MIM:602419
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    EGR-3; PILOT
    Summary
    This gene encodes a transcriptional regulator that belongs to the EGR family of C2H2-type zinc-finger proteins. It is an immediate-early growth response gene which is induced by mitogenic stimulation. The protein encoded by this gene participates in the transcriptional regulation of genes in controling biological rhythm. It may also play a role in a wide variety of processes including muscle development, lymphocyte development, endothelial cell growth and migration, and neuronal development. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Dec 2010]
    Expression
    Broad expression in gall bladder (RPKM 18.5), brain (RPKM 16.1) and 21 other tissues See more
    Orthologs

    Genomic context

    See EGR3 in Genome Data Viewer
    Location:
    8p21.3
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (22687659..22693480, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (22545172..22550815, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene bridging integrator 3 Neighboring gene BIN3 intronic transcript 1 Neighboring gene uncharacterized LOC105369180 Neighboring gene uncharacterized LOC107986924 Neighboring gene uncharacterized LOC105379322 Neighboring gene uncharacterized LOC105379321

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat The gene expression of early growth response 3 is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells PubMed
    tat HIV-1 Tat (through amino acids 30-40) binds to Egr-3 and synergizes with this protein to super induce the FasL promoter PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    • Calcineurin-regulated NFAT-dependent transcription in lymphocytes, organism-specific biosystem (from Pathway Interaction Database)
      Calcineurin-regulated NFAT-dependent transcription in lymphocytes, organism-specific biosystem
      Calcineurin-regulated NFAT-dependent transcription in lymphocytes
    • Circadian rythm related genes, organism-specific biosystem (from WikiPathways)
      Circadian rythm related genes, organism-specific biosystemThis is currently not a pathway but a list of circadian rhythm related genes and proteins. The source for this information is the gene ontology. The genes and proteins were filtered for "circadian rh...
    • Hepatitis B, organism-specific biosystem (from KEGG)
      Hepatitis B, organism-specific biosystemHepatitis B virus (HBV) is an enveloped virus and contains a partially double-stranded relaxed circular DNA (RC-DNA) genome. After entry into hepatocytes, HBV RC-DNA is transported to the nucleus and...
    • Viral carcinogenesis, organism-specific biosystem (from KEGG)
      Viral carcinogenesis, organism-specific biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...
    • Viral carcinogenesis, conserved biosystem (from KEGG)
      Viral carcinogenesis, conserved biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC138484

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    cell migration involved in sprouting angiogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to fibroblast growth factor stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to growth factor stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cellular response to vascular endothelial growth factor stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    circadian rhythm TAS
    Traceable Author Statement
    more info
    PubMed 
    endothelial cell chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    muscle organ development TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neuromuscular synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
     
    peripheral nervous system development IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of T cell differentiation in thymus IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of endothelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of gamma-delta T cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    early growth response protein 3
    Names
    zinc finger protein pilot

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001199880.2NP_001186809.1  early growth response protein 3 isoform 2

      See identical proteins and their annotated locations for NP_001186809.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) initiates from a distinct promoter and has a different 5' end, compared to variant (1). It encodes an isoform (2) with a shorter and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AC105046, AK294968, AK295134, N66802, S40832, X63741
      Consensus CDS
      CCDS56528.1
      UniProtKB/Swiss-Prot
      Q06889
      UniProtKB/TrEMBL
      B4DH80
      Related
      ENSP00000430310.1, ENST00000522910.1
      Conserved Domains (3) summary
      COG5048
      Location:265338
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:239261
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam11928
      Location:49109
      DUF3446; Domain of unknown function (DUF3446)
    2. NM_001199881.2NP_001186810.1  early growth response protein 3 isoform 3

      See identical proteins and their annotated locations for NP_001186810.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) initiates from a distinct promoter and has a different 5' end, compared to variant (1). It encodes an isoform (3) with a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC105046, AK294968, DC333411, N66802, S40832, X63741
      UniProtKB/Swiss-Prot
      Q06889
      UniProtKB/TrEMBL
      B4DH80
      Conserved Domains (5) summary
      COG5048
      Location:249305
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:223245
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:221245
      zf-C2H2; Zinc finger, C2H2 type
      pfam11928
      Location:3393
      DUF3446; Domain of unknown function (DUF3446)
      pfam13465
      Location:265290
      zf-H2C2_2; Zinc-finger double domain
    3. NM_004430.3NP_004421.2  early growth response protein 3 isoform 1

      See identical proteins and their annotated locations for NP_004421.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC105046, N66802, S40832, X63741
      Consensus CDS
      CCDS6033.1
      UniProtKB/Swiss-Prot
      Q06889
      Related
      ENSP00000318057.2, ENST00000317216.3
      Conserved Domains (5) summary
      COG5048
      Location:303359
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:277299
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:275299
      zf-C2H2; Zinc finger, C2H2 type
      pfam11928
      Location:87147
      DUF3446; Domain of unknown function (DUF3446)
      pfam13465
      Location:319344
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

      Range
      22687659..22693480 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005273426.3XP_005273483.1  early growth response protein 3 isoform X3

      See identical proteins and their annotated locations for XP_005273483.1

      UniProtKB/Swiss-Prot
      Q06889
      Conserved Domains (3) summary
      COG5048
      Location:265338
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:239261
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam11928
      Location:49109
      DUF3446; Domain of unknown function (DUF3446)
    2. XM_011544429.2XP_011542731.1  early growth response protein 3 isoform X2

      See identical proteins and their annotated locations for XP_011542731.1

      Conserved Domains (5) summary
      COG5048
      Location:322395
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:296318
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:294318
      zf-C2H2; Zinc finger, C2H2 type
      pfam11928
      Location:106166
      DUF3446; Domain of unknown function (DUF3446)
      pfam13465
      Location:338363
      zf-H2C2_2; Zinc-finger double domain
    3. XM_005273425.3XP_005273482.1  early growth response protein 3 isoform X1

      See identical proteins and their annotated locations for XP_005273482.1

      Conserved Domains (5) summary
      COG5048
      Location:358431
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:332354
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:330354
      zf-C2H2; Zinc finger, C2H2 type
      pfam11928
      Location:142202
      DUF3446; Domain of unknown function (DUF3446)
      pfam13465
      Location:374399
      zf-H2C2_2; Zinc-finger double domain
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