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    Rasa3 RAS p21 protein activator 3 [ Mus musculus (house mouse) ]

    Gene ID: 19414, updated on 30-Apr-2019

    Summary

    Official Symbol
    Rasa3provided by MGI
    Official Full Name
    RAS p21 protein activator 3provided by MGI
    Primary source
    MGI:MGI:1197013
    See related
    Ensembl:ENSMUSG00000031453
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    scat; C86362; GAPIII; hlb381; AI326412; E130011G04
    Expression
    Ubiquitous expression in spleen adult (RPKM 50.1), mammary gland adult (RPKM 30.6) and 28 other tissues See more
    Orthologs

    Genomic context

    See Rasa3 in Genome Data Viewer
    Location:
    8 A1.1; 8 6.29 cM
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 8 NC_000074.6 (13567218..13677587, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (13567218..13677587, complement)

    Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene transmembrane protein 255B Neighboring gene growth arrest specific 6 Neighboring gene RIKEN cDNA 1700029H14 gene Neighboring gene predicted gene, 34795 Neighboring gene predicted gene, 46032 Neighboring gene CFAP97 domain containing 2 Neighboring gene 3-phosphoglycerate dehydrogenase pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    severe combined anemia and thrombocytopenia
    GeneReviews: Not available

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    calcium-release channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cellular response to heat ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of Ras protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    intrinsic component of the cytoplasmic side of the plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ras GTPase-activating protein 3
    Names
    GAP1(IP4BP)
    GAPIII activator 3
    R-Ras gap
    R-ras RTPase activating protein-3
    Ras GTPase-activating protein III
    ins P4-binding protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009025.2NP_033051.2  ras GTPase-activating protein 3

      See identical proteins and their annotated locations for NP_033051.2

      Status: VALIDATED

      Source sequence(s)
      BC057300, CA749631
      Consensus CDS
      CCDS40234.1
      UniProtKB/Swiss-Prot
      Q60790
      Related
      ENSMUSP00000112998.2, ENSMUST00000117551.3
      Conserved Domains (7) summary
      smart00107
      Location:679714
      BTK; Bruton's tyrosine kinase Cys-rich motif
      cd04010
      Location:146288
      C2B_RasA3; C2 domain second repeat present in RAS p21 protein activator 3 (RasA3)
      cd08401
      Location:13133
      C2A_RasA2_RasA3; C2 domain first repeat present in RasA2 and RasA3
      cd05134
      Location:297565
      RasGAP_RASA3; Ras-GTPase Activating Domain of RASA3
      smart00323
      Location:275614
      RasGAP; GTPase-activator protein for Ras-like GTPases
      cd13371
      Location:562686
      PH_GAP1_mammal-like; GAP1(IP4BP) pleckstrin homology (PH) domain
      pfam00169
      Location:577676
      PH; PH domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000074.6 Reference GRCm38.p4 C57BL/6J

      Range
      13567218..13677587 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006508734.1XP_006508797.1  ras GTPase-activating protein 3 isoform X1

      Conserved Domains (7) summary
      smart00107
      Location:647682
      BTK; Bruton's tyrosine kinase Cys-rich motif
      cd04010
      Location:114256
      C2B_RasA3; C2 domain second repeat present in RAS p21 protein activator 3 (RasA3)
      cd08401
      Location:1101
      C2A_RasA2_RasA3; C2 domain first repeat present in RasA2 and RasA3
      cd05134
      Location:265533
      RasGAP_RASA3; Ras-GTPase Activating Domain of RASA3
      smart00323
      Location:243582
      RasGAP; GTPase-activator protein for Ras-like GTPases
      cd13371
      Location:530654
      PH_GAP1_mammal-like; GAP1(IP4BP) pleckstrin homology (PH) domain
      pfam00169
      Location:545644
      PH; PH domain
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