U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Ptpn12 protein tyrosine phosphatase, non-receptor type 12 [ Mus musculus (house mouse) ]

    Gene ID: 19248, updated on 11-Apr-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Ptpn12provided by MGI
    Official Full Name
    protein tyrosine phosphatase, non-receptor type 12provided by MGI
    Primary source
    MGI:MGI:104673
    See related
    Ensembl:ENSMUSG00000028771 AllianceGenome:MGI:104673
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PTPG1; P19-PTP; PTP-P19; PTP-PEST
    Summary
    Enables phosphoprotein phosphatase activity. Acts upstream of or within protein dephosphorylation. Located in cytosol and podosome. Is expressed in several structures, including central nervous system; embryo mesenchyme; extraembryonic component; gut; and retina. Human ortholog(s) of this gene implicated in colorectal cancer. Orthologous to human PTPN12 (protein tyrosine phosphatase non-receptor type 12). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E14 (RPKM 8.7), CNS E18 (RPKM 8.5) and 28 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    5 A3; 5 9.83 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (21191643..21261009, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (20986645..21055911, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_12554 Neighboring gene transmembrane protein 60 Neighboring gene round spermatid basic protein 1-like Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:20447096-20447297 Neighboring gene STARR-seq mESC enhancer starr_12555 Neighboring gene RIKEN cDNA A630072M18 gene Neighboring gene STARR-seq mESC enhancer starr_12556 Neighboring gene STARR-seq mESC enhancer starr_12557 Neighboring gene STARR-seq mESC enhancer starr_12559 Neighboring gene STARR-positive B cell enhancer mm9_chr5:20484581-20484882 Neighboring gene STARR-positive B cell enhancer mm9_chr5:20508606-20508906 Neighboring gene STARR-positive B cell enhancer ABC_E10306 Neighboring gene STARR-seq mESC enhancer starr_12560 Neighboring gene STARR-positive B cell enhancer mm9_chr5:20561662-20561962 Neighboring gene STARR-seq mESC enhancer starr_12561 Neighboring gene predicted gene, 42221 Neighboring gene predicted gene, 22490

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Control of dendritic cell migration, T cell-dependent immunity, and autoimmunity by protein tyrosine phosphatase PTPN12 expressed in dendritic cells. Rhee I, et al. Mol Cell Biol, 2014 Mar. PMID 24366546, Free PMC Article
    2. TCR-induced downregulation of protein tyrosine phosphatase PEST augments secondary T cell responses. Arimura Y, et al. Mol Immunol, 2008 Jun. PMID 18457880, Free PMC Article
    3. Structure of the murine MPTP-PEST gene: genomic organization and chromosomal mapping. Charest A, et al. Genomics, 1995 Aug 10. PMID 7490087
    4. Loss of PTPN12 Stimulates Progression of ErbB2-Dependent Breast Cancer by Enhancing Cell Survival, Migration, and Epithelial-to-Mesenchymal Transition. Li J, et al. Mol Cell Biol, 2015 Dec. PMID 26391955, Free PMC Article
    5. Protein tyrosine phosphatase with proline-glutamine-serine-threonine-rich motifs negatively regulates TLR-triggered innate responses by selectively inhibiting IκB kinase β/NF-κB activation. Zhang P, et al. J Immunol, 2013 Feb 15. PMID 23296707

    See all (57) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PTPN12-deficient, ErbB2-dependent breast cancer cells were more resistant to anoikis and had augmented migratory and invasive properties.
      Title: Loss of PTPN12 Stimulates Progression of ErbB2-Dependent Breast Cancer by Enhancing Cell Survival, Migration, and Epithelial-to-Mesenchymal Transition.
    2. Integrin beta 8 and PTP-PEST form protein complexes at the leading edge of migrating cells and balance patterns of Rac1 and Cdc42 signaling by controlling the subcellular localization and phosphorylation status of Rho GDP dissociation inhibitor 1.
      Title: Protein tyrosine phosphatase-PEST and β8 integrin regulate spatiotemporal patterns of RhoGDI1 activation in migrating cells.
    3. Pyk2 deregulation played a pivotal role in the migration defect caused by PTPN12 deficiency.
      Title: Control of dendritic cell migration, T cell-dependent immunity, and autoimmunity by protein tyrosine phosphatase PTPN12 expressed in dendritic cells.
    4. Regulation of the Src kinase-associated phosphoprotein 55 homologue by the protein tyrosine phosphatase PTP-PEST in the control of cell motility.
      Title: Regulation of the Src kinase-associated phosphoprotein 55 homologue by the protein tyrosine phosphatase PTP-PEST in the control of cell motility.
    5. macrophage fusion is critically dependent on PTP-PEST.
      Title: Macrophage fusion is controlled by the cytoplasmic protein tyrosine phosphatase PTP-PEST/PTPN12.
    6. Overexpression of PTP-PEST substantially inhibits lipopolysaccharide (LPS)-induced tyrosine phosphorylation of IkappaB kinase (IKKbeta) at Tyr188/199 in RAW264.7 cells.
      Title: Protein tyrosine phosphatase with proline-glutamine-serine-threonine-rich motifs negatively regulates TLR-triggered innate responses by selectively inhibiting IκB kinase β/NF-κB activation.
    7. PTP-PEST is a key regulator of integrin-mediated functions in endothelial cells.
      Title: The phosphatase PTP-PEST/PTPN12 regulates endothelial cell migration and adhesion, but not permeability, and controls vascular development and embryonic viability.
    8. the dephosphorylation of Pyk2 requires dynamin's GTPase activity and is mediated by the tyrosine phosphatase PTP-PEST.
      Title: Dynamin and PTP-PEST cooperatively regulate Pyk2 dephosphorylation in osteoclasts.
    9. PTP-PEST controls Pyk2 activity and is a positive regulator of secondary T cell activation.
      Title: The phosphatase PTP-PEST promotes secondary T cell responses by dephosphorylating the protein tyrosine kinase Pyk2.
    10. Data show that ERK phosphorylates FAK S910 and recruits PIN1 and PTP-PEST, which colocalize with FAK at the lamellipodia of migrating cells.
      Title: FAK phosphorylation by ERK primes ras-induced tyrosine dephosphorylation of FAK mediated by PIN1 and PTP-PEST.
    Submit: New GeneRIF Correction See all GeneRIFs (15)

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (6)  1 citation
    • Endonuclease-mediated (4) 

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SH3 domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables non-membrane spanning protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoprotein phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphoprotein phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to epidermal growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in peptidyl-tyrosine dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein dephosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein dephosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of epidermal growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in anchoring junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in podosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    tyrosine-protein phosphatase non-receptor type 12
    Names
    MPTP-PEST
    protein-tyrosine phosphatase P19
    NP_001343519.1
    NP_001343520.1
    NP_001343521.1
    NP_001411448.1
    NP_001411450.1
    NP_035333.2
    XP_030110077.1
    XP_036020804.1
    XP_036020805.1
    XP_036020806.1
    XP_036020807.1
    XP_036020808.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356590.1 → NP_001343519.1  tyrosine-protein phosphatase non-receptor type 12 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AC116501, AC121572
      Conserved Domains (1) summary
      cl28904
      Location:43 → 312
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    2. NM_001356591.2 → NP_001343520.1  tyrosine-protein phosphatase non-receptor type 12 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 3 and 4 both encode the same isoform (c).
      Source sequence(s)
      AC116501, AC121572
      Conserved Domains (1) summary
      cl28904
      Location:1 → 179
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    3. NM_001356592.1 → NP_001343521.1  tyrosine-protein phosphatase non-receptor type 12 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 3 and 4 both encode the same isoform (c).
      Source sequence(s)
      AC116501, AC121572
      Conserved Domains (1) summary
      cl28904
      Location:1 → 179
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    4. NM_001424519.1 → NP_001411448.1  tyrosine-protein phosphatase non-receptor type 12 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC116501, AC121572

    5. NM_001424521.1 → NP_001411450.1  tyrosine-protein phosphatase non-receptor type 12 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC116501, AC121572

    6. NM_011203.4 → NP_035333.2  tyrosine-protein phosphatase non-receptor type 12 isoform b

      See identical proteins and their annotated locations for NP_035333.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a.
      Source sequence(s)
      AC116501, AC121572
      Consensus CDS
      CCDS19102.1
      UniProtKB/Swiss-Prot
      P35831, Q80UM4
      Related
      ENSMUSP00000030556.8, ENSMUST00000030556.8
      Conserved Domains (2) summary
      smart00194
      Location:28 → 292
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:60 → 292
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      21191643..21261009 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036164914.1 → XP_036020807.1  tyrosine-protein phosphatase non-receptor type 12 isoform X4

      Conserved Domains (1) summary
      cl28904
      Location:1 → 179
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    2. XM_036164915.1 → XP_036020808.1  tyrosine-protein phosphatase non-receptor type 12 isoform X5

      Conserved Domains (1) summary
      cl28904
      Location:1 → 87
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    3. XM_036164912.1 → XP_036020805.1  tyrosine-protein phosphatase non-receptor type 12 isoform X2

      Conserved Domains (1) summary
      cl28904
      Location:43 → 312
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    4. XM_036164911.1 → XP_036020804.1  tyrosine-protein phosphatase non-receptor type 12 isoform X1

      Conserved Domains (1) summary
      cl28904
      Location:43 → 312
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    5. XM_036164913.1 → XP_036020806.1  tyrosine-protein phosphatase non-receptor type 12 isoform X3

      Conserved Domains (1) summary
      cl28904
      Location:1 → 179
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    6. XM_030254217.2 → XP_030110077.1  tyrosine-protein phosphatase non-receptor type 12 isoform X3

      Conserved Domains (1) summary
      cl28904
      Location:1 → 179
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    RNA

    1. XR_004942461.1 RNA Sequence

    2. XR_004942460.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P35831.3 GenPept UniProtKB/Swiss-Prot:P35831

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous