U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    DVL3 dishevelled segment polarity protein 3 [ Homo sapiens (human) ]

    Gene ID: 1857, updated on 22-Jan-2023

    Summary

    Official Symbol
    DVL3provided by HGNC
    Official Full Name
    dishevelled segment polarity protein 3provided by HGNC
    Primary source
    HGNC:HGNC:3087
    See related
    Ensembl:ENSG00000161202 MIM:601368; AllianceGenome:HGNC:3087
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DRS3
    Summary
    This gene is a member of a multi-gene family which shares strong similarity with the Drosophila dishevelled gene, dsh. The Drosophila dishevelled gene encodes a cytoplasmic phosphoprotein that regulates cell proliferation. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in placenta (RPKM 25.5), endometrium (RPKM 18.5) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See DVL3 in Genome Data Viewer
    Location:
    3q27.1
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    110 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (184155377..184173614)
    110 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (186964902..186982556)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (183873165..183891402)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 2B subunit epsilon Neighboring gene ribosomal protein S3 pseudogene 3 Neighboring gene Sharpr-MPRA regulatory region 1463 Neighboring gene Sharpr-MPRA regulatory region 464 Neighboring gene adaptor related protein complex 2 subunit mu 1 Neighboring gene ATP binding cassette subfamily F member 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA0208

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables beta-catenin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables frizzled binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables frizzled binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables frizzled binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables protease binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables small GTPase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in Wnt signaling pathway, planar cell polarity pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in Wnt signaling pathway, planar cell polarity pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in canonical Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in canonical Wnt signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in canonical Wnt signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in non-canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in non-canonical Wnt signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in non-canonical Wnt signaling pathway via JNK cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in planar cell polarity pathway involved in neural tube closure IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of GTPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of JUN kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of neuron projection arborization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein stabilization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of protein localization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    segment polarity protein dishevelled homolog DVL-3
    Names
    dishevelled 3 (homologous to Drosophila dsh)
    dishevelled, dsh homolog 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_046860.1 RefSeqGene

      Range
      5067..23304
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_1269

    mRNA and Protein(s)

    1. NM_004423.4NP_004414.3  segment polarity protein dishevelled homolog DVL-3

      See identical proteins and their annotated locations for NP_004414.3

      Status: REVIEWED

      Source sequence(s)
      AC131235, D86963, U75651
      Consensus CDS
      CCDS3253.1
      UniProtKB/Swiss-Prot
      Q92607, Q92997
      Related
      ENSP00000316054.3, ENST00000313143.9
      Conserved Domains (5) summary
      smart00021
      Location:182
      DAX; Domain present in Dishevelled and axin
      cd00992
      Location:247334
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd04438
      Location:413496
      DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...
      pfam02377
      Location:92245
      Dishevelled; Dishevelled specific domain
      pfam12316
      Location:500706
      Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      184155377..184173614
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      186964902..186982556
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)