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    Tnfrsf11b tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) [ Mus musculus (house mouse) ]

    Gene ID: 18383, updated on 12-Aug-2019

    Summary

    Official Symbol
    Tnfrsf11bprovided by MGI
    Official Full Name
    tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)provided by MGI
    Primary source
    MGI:MGI:109587
    See related
    Ensembl:ENSMUSG00000063727
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Opg; TR1; OCIF
    Expression
    Ubiquitous expression in placenta adult (RPKM 3.7), liver E18 (RPKM 2.2) and 25 other tissues See more
    Orthologs

    Genomic context

    See Tnfrsf11b in Genome Data Viewer
    Location:
    15; 15 D1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    108 current GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (54250619..54278484, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (54082174..54110039, complement)

    Chromosome 15 - NC_000081.6Genomic Context describing neighboring genes Neighboring gene sterile alpha motif domain containing 12 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene microRNA 28c Neighboring gene ribosomal protein L19 pseudogene Neighboring gene predicted gene 5215

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular matrix organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of bone resorption ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of odontogenesis of dentin-containing tooth IDA
    Inferred from Direct Assay
    more info
    PubMed 
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    extracellular matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space HDA PubMed 
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    tumor necrosis factor receptor superfamily member 11B
    Names
    osteoclastogenesis inhibitory factor
    osteoprotegerin

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008764.3NP_032790.3  tumor necrosis factor receptor superfamily member 11B precursor

      See identical proteins and their annotated locations for NP_032790.3

      Status: VALIDATED

      Source sequence(s)
      AC121114, AK140244
      Consensus CDS
      CCDS27468.1
      UniProtKB/Swiss-Prot
      O08712
      UniProtKB/TrEMBL
      Q3UK97
      Related
      ENSMUSP00000078705.3, ENSMUST00000079772.3
      Conserved Domains (3) summary
      cd00185
      Location:122185
      TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
      cd10581
      Location:7151
      TNFRSF11B; Tumor necrosis factor receptor superfamily member 11B (TNFRSF11B), also known as Osteoprotegerin (OPG)
      pfam00531
      Location:293365
      Death; Death domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p6 C57BL/6J

    Genomic

    1. NC_000081.6 Reference GRCm38.p6 C57BL/6J

      Range
      54250619..54278484 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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