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    AGT angiotensinogen [ Homo sapiens (human) ]

    Gene ID: 183, updated on 17-Jan-2022

    Summary

    Official Symbol
    AGTprovided by HGNC
    Official Full Name
    angiotensinogenprovided by HGNC
    Primary source
    HGNC:HGNC:333
    See related
    Ensembl:ENSG00000135744 MIM:106150
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ANHU; hFLT1; SERPINA8
    Summary
    The protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure, body fluid and electrolyte homeostasis, and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease. [provided by RefSeq, Nov 2019]
    Annotation information
    Note: This gene has been reviewed for its involvement in coronavirus biology, and is relevant for disease process.
    Expression
    Biased expression in liver (RPKM 264.6), brain (RPKM 76.5) and 3 other tissues See more
    Orthologs
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    Genomic context

    See AGT in Genome Data Viewer
    Location:
    1q42.2
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109.20211119 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (230702523..230745583, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (230838269..230881329, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein S24 pseudogene 4 Neighboring gene component of oligomeric golgi complex 2 Neighboring gene uncharacterized LOC107985358 Neighboring gene Sharpr-MPRA regulatory region 2465 Neighboring gene VISTA enhancer hs2133 Neighboring gene calpain 9 Neighboring gene uncharacterized LOC107985359

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat Microarray analysis indicates HIV-1 Tat-induced upregulation of angiotensinogen (AGT) in primary human brain microvascular endothelial cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ92595, FLJ97926

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables growth factor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables hormone activity IC
    Inferred by Curator
    more info
    PubMed 
    enables hormone activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables serine-type endopeptidase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables type 1 angiotensin receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables type 2 angiotensin receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in activation of phospholipase C activity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in aging IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in angiotensin-mediated drinking behavior IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in artery smooth muscle contraction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in associative learning IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in blood vessel remodeling TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in cell growth involved in cardiac muscle cell development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell-cell signaling TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in cellular response to angiotensin IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to mechanical stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular sodium ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in female pregnancy IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in fibroblast proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in kidney development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in low-density lipoprotein particle remodeling NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in maintenance of blood vessel diameter homeostasis by renin-angiotensin TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of MAP kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cell growth IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of neurotrophin TRK receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of tissue remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in nitric oxide mediated signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in operant conditioning IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of L-arginine import across plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of L-lysine import across plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of NAD(P)H oxidase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of NF-kappaB transcription factor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of activation of Janus kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of blood pressure IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of branching involved in ureteric bud morphogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cardiac muscle cell apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cardiac muscle hypertrophy ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of cellular protein metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cholesterol esterification IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cytokine production TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of cytosolic calcium ion concentration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of endothelial cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of epidermal growth factor receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of extracellular matrix constituent secretion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of extrinsic apoptotic signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of fibroblast proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of gap junction assembly IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of inflammatory response TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of insulin receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of macrophage derived foam cell differentiation IC
    Inferred by Curator
    more info
    PubMed 
    involved_in positive regulation of neuron projection development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of nitric oxide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of phosphatidylinositol 3-kinase signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of protein tyrosine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of reactive oxygen species metabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of renal sodium excretion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of superoxide anion generation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of vascular associated smooth muscle cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of vascular associated smooth muscle cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein import into nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of blood pressure IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of blood volume by renin-angiotensin NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in regulation of calcium ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of cardiac conduction IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of cell growth NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in regulation of cell population proliferation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in regulation of extracellular matrix assembly IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of heart rate IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of long-term neuronal synaptic plasticity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of norepinephrine secretion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of renal output by angiotensin NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in regulation of renal sodium excretion NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in regulation of transmission of nerve impulse IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of vasoconstriction NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in renal system process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in renin-angiotensin regulation of aldosterone production NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in response to estradiol IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to muscle activity involved in regulation of muscle adaptation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in smooth muscle cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in stress-activated MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in uterine smooth muscle contraction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in vasodilation IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    angiotensinogen
    Names
    alpha-1 antiproteinase, antitrypsin
    angiotensin I
    angiotensin II
    fetal-liver predominant transporter 1
    pre-angiotensinogen
    serine (or cysteine) proteinase inhibitor
    serpin A8
    serpin peptidase inhibitor, clade A, member 8

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008836.2 RefSeqGene

      Range
      5469..17068
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001382817.3NP_001369746.2  angiotensinogen precursor

      Status: REVIEWED

      Source sequence(s)
      AL158214, AL512328
      Related
      ENSP00000505985.1, ENST00000681269.1
      Conserved Domains (1) summary
      cd02054
      Location:28474
      serpinA8_AGT; serpin family A member 8, angiotensinogen
    2. NM_001384479.1NP_001371408.1  angiotensinogen precursor

      Status: REVIEWED

      Source sequence(s)
      AL158214, AL512328
      Consensus CDS
      CCDS1585.1
      Related
      ENSP00000355627.5, ENST00000366667.6
      Conserved Domains (1) summary
      cd02054
      Location:28474
      serpinA8_AGT; serpin family A member 8, angiotensinogen

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

      Range
      230702523..230745583 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_000029.4: Suppressed sequence

      Description
      NM_000029.4: This RefSeq was removed because currently there is support for the transcript but not for the protein.
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