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    Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha [ Mus musculus (house mouse) ]

    Gene ID: 18035, updated on 13-Aug-2022

    Summary

    Official Symbol
    Nfkbiaprovided by MGI
    Official Full Name
    nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alphaprovided by MGI
    Primary source
    MGI:MGI:104741
    See related
    Ensembl:ENSMUSG00000021025 AllianceGenome:MGI:104741
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nfkbi
    Summary
    Predicted to enable several functions, including NF-kappaB binding activity; nuclear localization sequence binding activity; and ubiquitin protein ligase binding activity. Acts upstream of or within several processes, including lipopolysaccharide-mediated signaling pathway; negative regulation of Notch signaling pathway; and pattern recognition receptor signaling pathway. Located in cytosol and nucleus. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; naris; and vibrissa follicle. Used to study Sjogren's syndrome and atopic dermatitis. Human ortholog(s) of this gene implicated in several diseases, including childhood-onset asthma; hematologic cancer (multiple); hepatitis B; hepatitis C; and lung disease (multiple). Orthologous to human NFKBIA (NFKB inhibitor alpha). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in thymus adult (RPKM 93.5), spleen adult (RPKM 74.5) and 26 other tissues See more
    Orthologs
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    Genomic context

    See Nfkbia in Genome Data Viewer
    Location:
    12; 12 C1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (55536194..55539432, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (55489409..55492647, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (56590396..56593634, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene mitochondrial import inner membrane translocase subunit Tim8 B pseudogene Neighboring gene predicted gene, 36571 Neighboring gene predicted gene, 36634 Neighboring gene aldolase 1 A, retrogene 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (8)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables NF-kappaB binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables NF-kappaB binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables heat shock protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nuclear localization sequence binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in I-kappaB kinase/NF-kappaB signaling ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of Notch signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to biotic stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to cytokine stimulus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to organic cyclic compound ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in cellular response to tumor necrosis factor IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to tumor necrosis factor IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cytoplasmic sequestering of NF-kappaB IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cytoplasmic sequestering of NF-kappaB ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cytoplasmic sequestering of transcription factor ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within lipopolysaccharide-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of Notch signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of lipid storage ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of macrophage derived foam cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of myeloid cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within nucleotide-binding oligomerization domain containing 1 signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within nucleotide-binding oligomerization domain containing 2 signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cholesterol efflux ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein import into nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within response to exogenous dsRNA IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within response to lipopolysaccharide IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within response to muramyl dipeptide IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within response to muscle stretch IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within toll-like receptor 4 signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in tumor necrosis factor-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    NF-kappa-B inhibitor alpha
    Names
    I(Kappa)B(alpha)
    I-kappa-B-alpha
    I-kappaBalpha
    ikB-alpha
    ikappaBalpha
    nuclear factor of kappa light chain gene enhancer in B-cells inhibitor, alpha
    nuclear factor of kappa light polyp gene enhancer in B-cell 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010907.2NP_035037.2  NF-kappa-B inhibitor alpha

      See identical proteins and their annotated locations for NP_035037.2

      Status: VALIDATED

      Source sequence(s)
      AC158398, AI462015, BC046754, CF379853
      Consensus CDS
      CCDS25918.1
      UniProtKB/Swiss-Prot
      Q80ZX5, Q9Z1E3
      Related
      ENSMUSP00000021413.8, ENSMUST00000021413.9
      Conserved Domains (3) summary
      cd00204
      Location:105237
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:143180
      ANK; ANK repeat [structural motif]
      cl26073
      Location:26151
      Ank_2; Ankyrin repeats (3 copies)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      55536194..55539432 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)