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    Ncl nucleolin [ Mus musculus (house mouse) ]

    Gene ID: 17975, updated on 7-Jul-2019

    Summary

    Official Symbol
    Nclprovided by MGI
    Official Full Name
    nucleolinprovided by MGI
    Primary source
    MGI:MGI:97286
    See related
    Ensembl:ENSMUSG00000026234
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C23; Nucl; D0Nds28; D1Nds28; B530004O11Rik
    Expression
    Biased expression in CNS E11.5 (RPKM 52.4), liver E14 (RPKM 41.1) and 11 other tissues See more
    Orthologs

    Genomic context

    See Ncl in Genome Data Viewer
    Location:
    1 C5; 1 43.94 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (86344719..86359455, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (88241294..88256030, complement)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene predicted gene 28626 Neighboring gene UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7 Neighboring gene predicted gene 5258 Neighboring gene small nucleolar RNA, H/ACA box 75 Neighboring gene predicted gene, 24148 Neighboring gene RIKEN cDNA C130036L24 gene Neighboring gene small nucleolar RNA, C/D box 82 Neighboring gene neuromedin U receptor 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • PluriNetWork, organism-specific biosystem (from WikiPathways)
      PluriNetWork, organism-specific biosystemThe aim of the PluriNetWork is to give an overview of specific mechanisms associated with pluripotency in mouse. Each node represents a gene and its corresponding protein product. As stated, we inten...
    • mRNA processing, organism-specific biosystem (from WikiPathways)
      mRNA processing, organism-specific biosystemAdapted from Reactome, see: [http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_1675.1 REACT 1675.1] This process describes the conversion of precursor messenger RNA into mature messenge...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    DNA topoisomerase binding ISO
    Inferred from Sequence Orthology
    more info
     
    ErbB-4 class receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    histone binding ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    laminin binding ISO
    Inferred from Sequence Orthology
    more info
     
    mRNA 5'-UTR binding ISO
    Inferred from Sequence Orthology
    more info
     
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein C-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    rRNA primary transcript binding ISO
    Inferred from Sequence Orthology
    more info
     
    selenocysteine insertion sequence binding ISO
    Inferred from Sequence Orthology
    more info
     
    sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    single-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    telomeric DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to epidermal growth factor stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to leukemia inhibitory factor IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to lipopolysaccharide ISO
    Inferred from Sequence Orthology
    more info
     
    endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of translation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of interleukin-6 secretion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of transcription of nucleolar large rRNA by RNA polymerase I ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of tumor necrosis factor production ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of rRNA processing ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cell cortex ISO
    Inferred from Sequence Orthology
    more info
     
    cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasmic ribonucleoprotein granule ISO
    Inferred from Sequence Orthology
    more info
     
    dense fibrillar component ISO
    Inferred from Sequence Orthology
    more info
     
    fibrillar center ISO
    Inferred from Sequence Orthology
    more info
     
    nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010880.3NP_035010.3  nucleolin

      See identical proteins and their annotated locations for NP_035010.3

      Status: VALIDATED

      Source sequence(s)
      AC102609, AK144894, CJ084318
      Consensus CDS
      CCDS35646.1
      UniProtKB/Swiss-Prot
      P09405
      Related
      ENSMUSP00000027438.6, ENSMUST00000027438.7
      Conserved Domains (4) summary
      cd12403
      Location:309383
      RRM1_NCL; RNA recognition motif 1 in vertebrate nucleolin
      cd12404
      Location:392467
      RRM2_NCL; RNA recognition motif 2 in vertebrate nucleolin
      cd12405
      Location:486558
      RRM3_NCL; RNA recognition motif 3 in vertebrate nucleolin
      cd12406
      Location:569646
      RRM4_NCL; RNA recognition motif 4 in vertebrate nucleolin

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      86344719..86359455 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006529238.3XP_006529301.1  nucleolin isoform X1

      Conserved Domains (4) summary
      cd12403
      Location:293367
      RRM1_NCL; RNA recognition motif 1 in vertebrate nucleolin
      cd12404
      Location:376451
      RRM2_NCL; RNA recognition motif 2 in vertebrate nucleolin
      cd12405
      Location:470542
      RRM3_NCL; RNA recognition motif 3 in vertebrate nucleolin
      cd12406
      Location:553630
      RRM4_NCL; RNA recognition motif 4 in vertebrate nucleolin
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