Format

Send to:

Choose Destination
    • Showing Current items.

    DXO decapping exoribonuclease [ Homo sapiens (human) ]

    Gene ID: 1797, updated on 5-Sep-2021

    Summary

    Official Symbol
    DXOprovided by HGNC
    Official Full Name
    decapping exoribonucleaseprovided by HGNC
    Primary source
    HGNC:HGNC:2992
    See related
    Ensembl:ENSG00000204348 MIM:605996
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NG6; RAI1; DOM3L; DOM3Z
    Summary
    This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. The function of its protein product is unknown, but its ubiquitous expression and conservation in both simple and complex eukaryotes suggests that this may be a housekeeping gene. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in testis (RPKM 17.8), adrenal (RPKM 16.9) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See DXO in Genome Data Viewer
    Location:
    6p21.33
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (31969811..31972290, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (31937592..31939915, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene complement factor B Neighboring gene negative elongation factor complex member E Neighboring gene microRNA 1236 Neighboring gene Ski2 like RNA helicase Neighboring gene serine/threonine kinase 19 Neighboring gene complement C4A (Rodgers blood group) Neighboring gene CYP21A1P recombination region Neighboring gene cytochrome P450 family 21 subfamily A member 1, pseudogene Neighboring gene tenascin XA (pseudogene)

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    GWAS of blood cell traits identifies novel associated loci and epistatic interactions in Caucasian and African-American children.
    GeneReviews: Not available
    Risk HLA-DQA1 and PLA(2)R1 alleles in idiopathic membranous nephropathy.
    GeneReviews: Not available

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 5'-3' exonuclease activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables RNA NAD-cap (NAD-forming) hydrolase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables RNA pyrophosphohydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables RNA pyrophosphohydrolase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables mRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables magnesium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in NAD-cap decapping IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in NAD-cap decapping IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in RNA destabilization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in mRNA catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in mRNA catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in nuclear mRNA surveillance ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in nuclear-transcribed mRNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in nucleic acid phosphodiester bond hydrolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in nucleic acid phosphodiester bond hydrolysis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    decapping and exoribonuclease protein
    Names
    5'-3' exoribonuclease DXO
    NAD-capped RNA hydrolase DXO
    deNADding enzyme DXO
    protein Dom3Z
    NP_001358134.1
    NP_001358135.1
    NP_005501.2
    XP_006715068.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001371205.1NP_001358134.1  decapping and exoribonuclease protein isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Both variants 1 and 3 encode the same protein.
      Source sequence(s)
      AL645922
      Conserved Domains (1) summary
      pfam08652
      Location:51118
      RAI1; RAI1 like PD-(D/E)XK nuclease
    2. NM_001371206.1NP_001358135.1  decapping and exoribonuclease protein isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 3 encode the same protein.
      Source sequence(s)
      AL645922
      Related
      ENST00000474587.1
      Conserved Domains (1) summary
      pfam08652
      Location:51118
      RAI1; RAI1 like PD-(D/E)XK nuclease
    3. NM_005510.4NP_005501.2  decapping and exoribonuclease protein isoform 2

      See identical proteins and their annotated locations for NP_005501.2

      Status: REVIEWED

      Source sequence(s)
      AF059252, BC019083
      Consensus CDS
      CCDS4732.1
      UniProtKB/Swiss-Prot
      O77932
      UniProtKB/TrEMBL
      A0A024RCW8
      Related
      ENSP00000337759.5, ENST00000337523.10
      Conserved Domains (1) summary
      pfam08652
      Location:235302
      RAI1; RAI1 like PD-(D/E)XK nuclease

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

      Range
      31969811..31972290 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006715005.3XP_006715068.1  decapping and exoribonuclease protein isoform X1

      See identical proteins and their annotated locations for XP_006715068.1

      UniProtKB/Swiss-Prot
      O77932
      UniProtKB/TrEMBL
      A0A024RCW8
      Related
      ENSP00000364498.3, ENST00000375349.7
      Conserved Domains (1) summary
      pfam08652
      Location:235302
      RAI1; RAI1 like PD-(D/E)XK nuclease

    RNA

    1. XR_002956264.1 RNA Sequence

    2. XR_002956263.1 RNA Sequence

    3. XR_002956262.1 RNA Sequence

    4. XR_926082.2 RNA Sequence

    Reference GRCh38.p13 ALT_REF_LOCI_2

    Genomic

    1. NT_113891.3 Reference GRCh38.p13 ALT_REF_LOCI_2

      Range
      3447242..3449565 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p13 ALT_REF_LOCI_3

    Genomic

    1. NT_167245.2 Reference GRCh38.p13 ALT_REF_LOCI_3

      Range
      3217590..3219913 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p13 ALT_REF_LOCI_5

    Genomic

    1. NT_167247.2 Reference GRCh38.p13 ALT_REF_LOCI_5

      Range
      3311851..3314174 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p13 ALT_REF_LOCI_6

    Genomic

    1. NT_167248.2 Reference GRCh38.p13 ALT_REF_LOCI_6

      Range
      3225785..3228108 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p13 ALT_REF_LOCI_7

    Genomic

    1. NT_167249.2 Reference GRCh38.p13 ALT_REF_LOCI_7

      Range
      3271004..3273327 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center