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    Myh8 myosin, heavy polypeptide 8, skeletal muscle, perinatal [ Mus musculus (house mouse) ]

    Gene ID: 17885, updated on 4-Jun-2019

    Summary

    Official Symbol
    Myh8provided by MGI
    Official Full Name
    myosin, heavy polypeptide 8, skeletal muscle, perinatalprovided by MGI
    Primary source
    MGI:MGI:1339712
    See related
    Ensembl:ENSMUSG00000055775
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MHCp; Myhsp; Myhs-p; MyHC-pn; AI327267; 4832426G23Rik
    Summary
    This gene encodes a myosin heavy chain. The encoded protein forms a hexamer with two heavy chains, two alkali light chains, and two regulatory light chain components. This complex functions in muscle contraction. This gene is located in a cluster of related genes on chromosome 11. [provided by RefSeq, Jun 2013]
    Expression
    Biased expression in limb E14.5 (RPKM 10.6), lung adult (RPKM 9.3) and 5 other tissues See more

    Genomic context

    See Myh8 in Genome Data Viewer
    Location:
    11 B3; 11 40.59 cM
    Exon count:
    40
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (67277124..67308634)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (67090626..67122136)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene myosin heavy chain gene antisense RNA Neighboring gene myosin, heavy polypeptide 4, skeletal muscle Neighboring gene nuclear encoded tRNA proline 2 (anticodon TGG) Neighboring gene myosin, heavy polypeptide 13, skeletal muscle Neighboring gene predicted gene, 40029 Neighboring gene predicted gene, 31459

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA4211

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    ATPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    actin filament binding IEA
    Inferred from Electronic Annotation
    more info
     
    microfilament motor activity ISO
    Inferred from Sequence Orthology
    more info
     
    motor activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    ATP metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    muscle filament sliding ISO
    Inferred from Sequence Orthology
    more info
     
    skeletal muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    myosin complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    myosin filament IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    myosin-8
    Names
    Beta-MHC antisense
    myHC-perinatal
    myosin heavy chain 8
    myosin heavy chain, skeletal muscle, perinatal

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177369.3NP_796343.2  myosin-8

      See identical proteins and their annotated locations for NP_796343.2

      Status: REVIEWED

      Source sequence(s)
      AL596129
      Consensus CDS
      CCDS24857.1
      UniProtKB/Swiss-Prot
      P13542
      Related
      ENSMUSP00000019625.5, ENSMUST00000019625.11
      Conserved Domains (6) summary
      cl22853
      Location:102769
      Motor_domain; Myosin and Kinesin motor domain
      pfam00063
      Location:90769
      Myosin_head; Myosin head (motor domain)
      pfam01576
      Location:8491926
      Myosin_tail_1; Myosin tail
      pfam02736
      Location:3875
      Myosin_N; Myosin N-terminal SH3-like domain
      pfam06273
      Location:10421099
      eIF-4B; Plant specific eukaryotic initiation factor 4B
      cl19764
      Location:13751550
      COG6; Conserved oligomeric complex COG6

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      67277124..67308634
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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