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    lin-54 CRC domain-containing protein;Protein lin-54 [ Caenorhabditis elegans ]

    Gene ID: 178280, updated on 23-Nov-2023

    Summary

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    Gene symbol
    lin-54
    Gene description
    CRC domain-containing protein;Protein lin-54
    Primary source
    WormBase:WBGene00003037
    Locus tag
    CELE_JC8.6
    See related
    AllianceGenome:WB:WBGene00003037
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in autosome and condensed nuclear chromosome. Part of DRM complex. Is expressed in several structures, including pharynx and vulva. Orthologous to human LIN54 (lin-54 DREAM MuvB core complex component) and TESMIN (testis expressed metallothionein like protein). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: IV
    Exon count:
    7
    Sequence:
    Chromosome: IV; NC_003282.8 (13241044..13243401)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene SAC3/GANP/THP3 conserved domain-containing protein Neighboring gene ncRNA Neighboring gene Large ribosomal subunit protein uL11 Neighboring gene CMP/dCMP-type deaminase domain-containing protein Neighboring gene Cytochrome c oxidase assembly protein COX11, mitochondrial

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Opposing activities of DRM and MES-4 tune gene expression and X-chromosome repression in Caenorhabditis elegans germ cells. Tabuchi TM, et al. G3 (Bethesda), 2014 Jan 10. PMID 24281426, Free PMC Article
    2. A gene recommender algorithm to identify coexpressed genes in C. elegans. Owen AB, et al. Genome Res, 2003 Aug. PMID 12902378, Free PMC Article
    3. New genes that interact with lin-35 Rb to negatively regulate the let-60 ras pathway in Caenorhabditis elegans. Thomas JH, et al. Genetics, 2003 May. PMID 12750327, Free PMC Article
    4. Wnt Signaling Drives Ectopic Gene Expression and Larval Arrest in the Absence of the Caenorhabditis elegans DREAM Repressor Complex. Cherian JR, et al. G3 (Bethesda), 2020 Feb 6. PMID 31843805, Free PMC Article
    5. Loss of the Caenorhabditis elegans pocket protein LIN-35 reveals MuvB's innate function as the repressor of DREAM target genes. Goetsch PD, et al. PLoS Genet, 2017 Nov. PMID 29091720, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of DRM complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in autosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in condensed nuclear chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    CRC domain-containing protein;Protein lin-54
    NP_001360500.1
    • Confirmed by transcript evidence
    NP_001360501.1
    • Confirmed by transcript evidence
    NP_502544.1
    • Confirmed by transcript evidence
    NP_502545.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      13241044..13243401
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_070144.6 → NP_502545.1  Protein lin-54 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_502545.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95QD7
      Conserved Domains (1) summary
      pfam03638
      Location:244 → 281
      TCR; Tesmin/TSO1-like CXC domain, cysteine-rich domain

    2. NM_001372945.2 → NP_001360500.1  CRC domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A486WWG3
      Conserved Domains (1) summary
      pfam03638
      Location:248 → 282
      TCR; Tesmin/TSO1-like CXC domain, cysteine-rich domain

    3. NM_001372946.3 → NP_001360501.1  CRC domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A486WX88
      Conserved Domains (1) summary
      pfam03638
      Location:248 → 282
      TCR; Tesmin/TSO1-like CXC domain, cysteine-rich domain

    4. NM_070143.4 → NP_502544.1  Protein lin-54 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_502544.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O62295, Q95QD7
      Conserved Domains (1) summary
      pfam03638
      Location:250 → 287
      TCR; Tesmin/TSO1-like CXC domain, cysteine-rich domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95QD7.1

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