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    DLG1 discs large MAGUK scaffold protein 1 [ Homo sapiens (human) ]

    Gene ID: 1739, updated on 7-Apr-2024

    Summary

    Official Symbol
    DLG1provided by HGNC
    Official Full Name
    discs large MAGUK scaffold protein 1provided by HGNC
    Primary source
    HGNC:HGNC:2900
    See related
    Ensembl:ENSG00000075711 MIM:601014; AllianceGenome:HGNC:2900
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    hdlg; DLGH1; SAP97; SAP-97
    Summary
    This gene encodes a multi-domain scaffolding protein that is required for normal development. This protein may have a role in septate junction formation, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. A multitude of transcript variants deriving from alternative splicing and the use of multiple alternate promoter have been observed, including some splice variants that may be specific to brain and other tissues. An upstream uORF may regulate translation at some splice variants of this gene. [provided by RefSeq, Sep 2018]
    Expression
    Ubiquitous expression in thyroid (RPKM 13.8), brain (RPKM 11.7) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See DLG1 in Genome Data Viewer
    Location:
    3q29
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (197042560..197299321, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (199768533..200020586, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (196769431..197026192, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 2091 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15080 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15081 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15082 Neighboring gene ribosomal protein SA pseudogene 30 Neighboring gene MELTF antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21107 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15083 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15084 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:196756444-196757080 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:196757081-196757717 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr3:196758105-196759304 Neighboring gene melanotransferrin Neighboring gene MPRA-validated peak4992 silencer Neighboring gene ReSE screen-validated silencer GRCh37_chr3:196860144-196860342 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:196930580-196931118 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15086 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15087 Neighboring gene microRNA 4797 Neighboring gene DLG1 antisense RNA 1 Neighboring gene uncharacterized LOC101926923 Neighboring gene uncharacterized LOC124906373

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Integrated Genome-wide Association, Coexpression Network, and Expression Single Nucleotide Polymorphism Analysis Identifies Novel Pathway in Allergic Rhinitis.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp160, precursor env DLG1 knockdown enhances the amount of Env in producer cells and virions. DLG1 knockdown is associated with the redistribution and colocalization of Env toward CD63 and CD82 positive vesicle-like structures PubMed
    Pr55(Gag) gag DLG1 knockdown is associated with the redistribution and colocalization of Gag toward CD63 and CD82 positive vesicle-like structures PubMed
    gag Endogenous DLG1 interacts with HIV-1 Gag in HIV-1-infected T cells. The NC domain of Gag is required for the interaction with DLG1 PubMed
    nucleocapsid gag Endogenous DLG1 interacts with HIV-1 Gag in HIV-1-infected T cells. The NC domain of Gag is required for the interaction with DLG1 PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • DKFZp761P0818, DKFZp781B0426

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables L27 domain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables cadherin binding HDA PubMed 
    enables cytoskeletal protein binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables guanylate kinase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables molecular adaptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables phosphoprotein phosphatase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables potassium channel regulator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables potassium channel regulator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables potassium channel regulator activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables structural constituent of postsynaptic density IEA
    Inferred from Electronic Annotation
    more info
     
    enables transmembrane transporter binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in GDP metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in GMP metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in T cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in actin filament organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in actin filament polymerization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in amyloid precursor protein metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in astral microtubule organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in bicellular tight junction assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in branching involved in ureteric bud morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell-cell adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cortical actin cytoskeleton organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cortical microtubule organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in embryo development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in embryonic skeletal system morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in endothelial cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in establishment of centrosome localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in establishment or maintenance of cell polarity TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in establishment or maintenance of epithelial cell apical/basal polarity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in establishment or maintenance of epithelial cell apical/basal polarity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in hard palate development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in immunological synapse formation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lens development in camera-type eye IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in maintenance of postsynaptic density structure IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in membrane raft organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of ERK1 and ERK2 cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of G1/S transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of T cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of epithelial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of p38MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neurotransmitter receptor localization to postsynaptic specialization membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in peristalsis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of actin filament polymerization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of potassium ion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of protein localization to plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein localization to plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein localization to plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in protein-containing complex localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in receptor clustering IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of cell shape IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of membrane potential IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of myelination IEA
    Inferred from Electronic Annotation
    more info
     
    NOT involved_in regulation of non-canonical NF-kappaB signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of potassium ion export across plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in regulation of potassium ion import ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in regulation of protein localization to synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of sodium ion transmembrane transport TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of ventricular cardiac muscle cell action potential ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in reproductive structure development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in smooth muscle tissue development IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of MPP7-DLG1-LIN7 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in adherens junction NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in basement membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in basolateral plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in bicellular tight junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell projection membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell-cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasmic side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in immunological synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in immunological synapse TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in intercalated disc TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in lateral loop IEA
    Inferred from Electronic Annotation
    more info
     
    located_in lateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane raft IEA
    Inferred from Electronic Annotation
    more info
     
    located_in microtubule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in myelin sheath abaxonal region IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in neuromuscular junction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in node of Ranvier IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    is_active_in postsynaptic density membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in sarcolemma IEA
    Inferred from Electronic Annotation
    more info
     
    located_in synaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    disks large homolog 1
    Names
    dJ1061C18.1.1
    discs large homolog 1, scribble cell polarity complex component
    presynaptic protein SAP97
    synapse-associated protein 97

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029099.1 RefSeqGene

      Range
      4965..261017
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001098424.1NP_001091894.1  disks large homolog 1 isoform 1

      See identical proteins and their annotated locations for NP_001091894.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AC068302, AC092937, U13897
      Consensus CDS
      CCDS43194.1
      UniProtKB/Swiss-Prot
      A5YKK7, B4DGU1, B4DGZ8, B7ZMM0, B9EIQ5, D3DXB8, D3DXB9, E7EWL7, E9PG21, Q12958, Q12959
      UniProtKB/TrEMBL
      A0A590UJR5
      Related
      ENSP00000391732.2, ENST00000448528.6
      Conserved Domains (7) summary
      cd12031
      Location:582648
      SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1
      smart00228
      Location:463547
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:224308
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:713891
      Guanylate_kin; Guanylate kinase
      pfam09058
      Location:262
      L27_1
      pfam10600
      Location:404465
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:106223
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
    2. NM_001204386.1NP_001191315.1  disks large homolog 1 isoform 3

      See identical proteins and their annotated locations for NP_001191315.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) is missing an in-frame coding exon, and contains an alternate in-frame coding exon compared to variant 1. This results in a shorter isoform (3) compared to isoform 1.
      Source sequence(s)
      AA837080, AC068302, AI223994, AK293967, BC042118, BC144651, BM728664, EF553524, U13897
      Consensus CDS
      CCDS75072.1
      UniProtKB/TrEMBL
      A0A0C4DFT3, A0A590UJC5
      Related
      ENSP00000499584.1, ENST00000656944.1
      Conserved Domains (7) summary
      cd12031
      Location:549615
      SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1
      smart00228
      Location:430514
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:191275
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:701879
      Guanylate_kin; Guanylate kinase
      pfam09058
      Location:262
      L27_1
      pfam10600
      Location:371432
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:106190
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
    3. NM_001204387.2NP_001191316.1  disks large homolog 1 isoform 4

      See identical proteins and their annotated locations for NP_001191316.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) contains an alternate 5' terminal exon, missing an in-frame coding exon, and contains an additional in-frame coding exon compared to variant 1. This results in a shorter isoform (4) with an unique N-terminus compared to isoform 1.
      Source sequence(s)
      AA837080, AC068302, AI223994, AK293967, AK294772, AK294855, BC042118, BM728664, EF553524
      Consensus CDS
      CCDS56301.1
      UniProtKB/TrEMBL
      A0A590UJR4
      Related
      ENSP00000396658.1, ENST00000443183.5
      Conserved Domains (6) summary
      cd12031
      Location:466532
      SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1
      smart00228
      Location:347431
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:108192
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:609787
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:288349
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:21107
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
    4. NM_001204388.2NP_001191317.1  disks large homolog 1 isoform 5

      See identical proteins and their annotated locations for NP_001191317.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) contains an alternate 5' terminal exon and is missing an in-frame coding exon compared to variant 1. This results in a shorter isoform (5) with an unique N-terminus compared to isoform 1.
      Source sequence(s)
      AA837080, AC068302, AI223994, AK294855, BC042118, BC144651, BM728664, EF553524
      Consensus CDS
      CCDS56300.1
      UniProtKB/TrEMBL
      A0A590UJR4
      Related
      ENSP00000398939.1, ENST00000452595.5
      Conserved Domains (6) summary
      cd12031
      Location:466532
      SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1
      smart00228
      Location:347431
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:108192
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:597775
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:288349
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:21107
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
    5. NM_001290983.2NP_001277912.1  disks large homolog 1 isoform 1

      See identical proteins and their annotated locations for NP_001277912.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR, compared to variant 1. Both variants 1 and 6 encode the same isoform (1).
      Source sequence(s)
      AA837080, AC068302, AC092937, EF553524, U13897
      Consensus CDS
      CCDS43194.1
      UniProtKB/Swiss-Prot
      A5YKK7, B4DGU1, B4DGZ8, B7ZMM0, B9EIQ5, D3DXB8, D3DXB9, E7EWL7, E9PG21, Q12958, Q12959
      UniProtKB/TrEMBL
      A0A590UJR5
      Related
      ENSP00000407531.1, ENST00000419354.5
      Conserved Domains (7) summary
      cd12031
      Location:582648
      SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1
      smart00228
      Location:463547
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:224308
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:713891
      Guanylate_kin; Guanylate kinase
      pfam09058
      Location:262
      L27_1
      pfam10600
      Location:404465
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:106223
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
    6. NM_001363865.1NP_001350794.1  disks large homolog 1 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC068302, AC092937
      Consensus CDS
      CCDS87192.1
      UniProtKB/TrEMBL
      A0A590UJC5
      Related
      ENSP00000350303.6, ENST00000357674.9
      Conserved Domains (7) summary
      cd12031
      Location:549615
      SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1
      smart00228
      Location:430514
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:191275
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:702880
      Guanylate_kin; Guanylate kinase
      pfam09058
      Location:262
      L27_1
      pfam10600
      Location:371432
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:106190
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
    7. NM_001366203.1NP_001353132.1  disks large homolog 1 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC068302, AC092937
      Consensus CDS
      CCDS93450.1
      UniProtKB/TrEMBL
      A0A590UJ68, A0A590UJR5
      Related
      ENSP00000499313.1, ENST00000667104.1
      Conserved Domains (7) summary
      cd12031
      Location:531597
      SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1
      smart00228
      Location:412496
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:173257
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:674852
      Guanylate_kin; Guanylate kinase
      pfam09058
      Location:262
      L27_1
      pfam10600
      Location:353414
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:106172
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
    8. NM_001366204.1NP_001353133.1  disks large homolog 1 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC068302, AC092937
      Consensus CDS
      CCDS93452.1
      UniProtKB/TrEMBL
      A0A590UJR5
      Related
      ENSP00000499602.1, ENST00000659716.1
      Conserved Domains (7) summary
      cd12031
      Location:549615
      SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1
      smart00228
      Location:430514
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:191275
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:680858
      Guanylate_kin; Guanylate kinase
      pfam09058
      Location:262
      L27_1
      pfam10600
      Location:371432
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:106190
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
    9. NM_001366205.1NP_001353134.1  disks large homolog 1 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC068302, AC092937
      Consensus CDS
      CCDS75072.1
      UniProtKB/TrEMBL
      A0A0C4DFT3, A0A590UJC5
      Related
      ENSP00000499507.1, ENST00000657381.1
      Conserved Domains (7) summary
      cd12031
      Location:549615
      SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1
      smart00228
      Location:430514
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:191275
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:701879
      Guanylate_kin; Guanylate kinase
      pfam09058
      Location:262
      L27_1
      pfam10600
      Location:371432
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:106190
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
    10. NM_001366206.1NP_001353135.1  disks large homolog 1 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC068302, AC092937
      Consensus CDS
      CCDS93451.1
      UniProtKB/TrEMBL
      A0A590UJ08, A0A590UJC5
      Related
      ENSP00000499229.1, ENST00000661336.1
      Conserved Domains (7) summary
      cd12031
      Location:531597
      SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1
      smart00228
      Location:412496
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:173257
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:684862
      Guanylate_kin; Guanylate kinase
      pfam09058
      Location:262
      L27_1
      pfam10600
      Location:353414
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:106172
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
    11. NM_001366207.1NP_001353136.1  disks large homolog 1 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC068302, AC092937
      Consensus CDS
      CCDS87192.1
      UniProtKB/TrEMBL
      A0A590UJC5
      Related
      ENSP00000499414.1, ENST00000667157.1
      Conserved Domains (7) summary
      cd12031
      Location:549615
      SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1
      smart00228
      Location:430514
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:191275
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:702880
      Guanylate_kin; Guanylate kinase
      pfam09058
      Location:262
      L27_1
      pfam10600
      Location:371432
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:106190
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
    12. NM_001366208.1NP_001353137.1  disks large homolog 1 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC068302, AC092937
      Consensus CDS
      CCDS93452.1
      UniProtKB/TrEMBL
      A0A590UJR5
      Related
      ENSP00000499657.1, ENST00000655488.1
      Conserved Domains (7) summary
      cd12031
      Location:549615
      SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1
      smart00228
      Location:430514
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:191275
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:680858
      Guanylate_kin; Guanylate kinase
      pfam09058
      Location:262
      L27_1
      pfam10600
      Location:371432
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:106190
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
    13. NM_001366209.1NP_001353138.1  disks large homolog 1 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC068302, AC092937
      Consensus CDS
      CCDS93452.1
      UniProtKB/TrEMBL
      A0A590UJR5
      Related
      ENSP00000499580.1, ENST00000671185.1
      Conserved Domains (7) summary
      cd12031
      Location:549615
      SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1
      smart00228
      Location:430514
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:191275
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:680858
      Guanylate_kin; Guanylate kinase
      pfam09058
      Location:262
      L27_1
      pfam10600
      Location:371432
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:106190
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
    14. NM_001366210.1NP_001353139.1  disks large homolog 1 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC068302, AC092937
      Consensus CDS
      CCDS87192.1
      UniProtKB/TrEMBL
      A0A590UJC5
      Related
      ENSP00000499413.1, ENST00000669565.1
      Conserved Domains (7) summary
      cd12031
      Location:549615
      SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1
      smart00228
      Location:430514
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:191275
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:702880
      Guanylate_kin; Guanylate kinase
      pfam09058
      Location:262
      L27_1
      pfam10600
      Location:371432
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:106190
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
    15. NM_001366211.1NP_001353140.1  disks large homolog 1 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC068302, AC092937
      Consensus CDS
      CCDS93453.1
      UniProtKB/TrEMBL
      A0A590UJR5, A0A590UKA8
      Related
      ENSP00000499723.1, ENST00000656087.1
      Conserved Domains (7) summary
      cd12031
      Location:549615
      SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1
      smart00228
      Location:430514
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:191275
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:692870
      Guanylate_kin; Guanylate kinase
      pfam09058
      Location:262
      L27_1
      pfam10600
      Location:371432
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:106190
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
    16. NM_001366212.1NP_001353141.1  disks large homolog 1 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC068302, AC092937
      Consensus CDS
      CCDS93452.1
      UniProtKB/TrEMBL
      A0A590UJR5
      Related
      ENSP00000499514.1, ENST00000661453.1
      Conserved Domains (7) summary
      cd12031
      Location:549615
      SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1
      smart00228
      Location:430514
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:191275
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:680858
      Guanylate_kin; Guanylate kinase
      pfam09058
      Location:262
      L27_1
      pfam10600
      Location:371432
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:106190
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
    17. NM_001366213.1NP_001353142.1  disks large homolog 1 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC068302, AC092937
      Consensus CDS
      CCDS75072.1
      UniProtKB/TrEMBL
      A0A0C4DFT3, A0A590UJC5
      Related
      ENSP00000499269.1, ENST00000659221.1
      Conserved Domains (7) summary
      cd12031
      Location:549615
      SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1
      smart00228
      Location:430514
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:191275
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:701879
      Guanylate_kin; Guanylate kinase
      pfam09058
      Location:262
      L27_1
      pfam10600
      Location:371432
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:106190
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
    18. NM_001366214.1NP_001353143.1  disks large homolog 1 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC068302, AC092937
      Consensus CDS
      CCDS93454.1
      UniProtKB/TrEMBL
      A0A590UJC5, A0A590UJD9
      Related
      ENSP00000499363.1, ENST00000660898.1
      Conserved Domains (7) summary
      cd12031
      Location:582648
      SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1
      smart00228
      Location:463547
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:224308
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:734912
      Guanylate_kin; Guanylate kinase
      pfam09058
      Location:262
      L27_1
      pfam10600
      Location:404465
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:106223
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
    19. NM_001366215.1NP_001353144.1  disks large homolog 1 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC068302, AC092937
      Consensus CDS
      CCDS87192.1
      UniProtKB/TrEMBL
      A0A590UJC5
      Related
      ENSP00000499542.1, ENST00000670455.1
      Conserved Domains (7) summary
      cd12031
      Location:549615
      SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1
      smart00228
      Location:430514
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:191275
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:702880
      Guanylate_kin; Guanylate kinase
      pfam09058
      Location:262
      L27_1
      pfam10600
      Location:371432
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:106190
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
    20. NM_001366216.1NP_001353145.1  disks large homolog 1 isoform 12

      Status: REVIEWED

      Source sequence(s)
      AC068302, AC092937
      Consensus CDS
      CCDS93449.1
      UniProtKB/TrEMBL
      A0A590UJR5
      Related
      ENSP00000413238.1, ENST00000422288.6
      Conserved Domains (7) summary
      cd12031
      Location:531597
      SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1
      smart00228
      Location:412496
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:173257
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:662840
      Guanylate_kin; Guanylate kinase
      pfam09058
      Location:262
      L27_1
      pfam10600
      Location:353414
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:106172
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
    21. NM_001366217.1NP_001353146.1  disks large homolog 1 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC068302, AC092937
      Consensus CDS
      CCDS93453.1
      UniProtKB/TrEMBL
      A0A590UJR5, A0A590UKA8
      Related
      ENSP00000499774.1, ENST00000662727.1
      Conserved Domains (7) summary
      cd12031
      Location:549615
      SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1
      smart00228
      Location:430514
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:191275
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:692870
      Guanylate_kin; Guanylate kinase
      pfam09058
      Location:262
      L27_1
      pfam10600
      Location:371432
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:106190
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
    22. NM_001366218.1NP_001353147.1  disks large homolog 1 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC068302, AC092937
      Consensus CDS
      CCDS43194.1
      UniProtKB/Swiss-Prot
      A5YKK7, B4DGU1, B4DGZ8, B7ZMM0, B9EIQ5, D3DXB8, D3DXB9, E7EWL7, E9PG21, Q12958, Q12959
      UniProtKB/TrEMBL
      A0A590UJR5
      Related
      ENSP00000499437.1, ENST00000670935.1
      Conserved Domains (7) summary
      cd12031
      Location:582648
      SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1
      smart00228
      Location:463547
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:224308
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:713891
      Guanylate_kin; Guanylate kinase
      pfam09058
      Location:262
      L27_1
      pfam10600
      Location:404465
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:106223
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
    23. NM_001366219.1NP_001353148.1  disks large homolog 1 isoform 12

      Status: REVIEWED

      Source sequence(s)
      AC068302, AC092937
      Consensus CDS
      CCDS93449.1
      UniProtKB/TrEMBL
      A0A590UJR5
      Related
      ENSP00000499793.1, ENST00000666007.1
      Conserved Domains (7) summary
      cd12031
      Location:531597
      SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1
      smart00228
      Location:412496
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:173257
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:662840
      Guanylate_kin; Guanylate kinase
      pfam09058
      Location:262
      L27_1
      pfam10600
      Location:353414
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:106172
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
    24. NM_001366220.1NP_001353149.1  disks large homolog 1 isoform 13

      Status: REVIEWED

      Source sequence(s)
      AC068302, AC092937
      UniProtKB/TrEMBL
      A0A590UJC5
      Conserved Domains (7) summary
      cd12031
      Location:531597
      SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1
      smart00228
      Location:412496
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:173257
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:683861
      Guanylate_kin; Guanylate kinase
      pfam09058
      Location:262
      L27_1
      pfam10600
      Location:353414
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:106172
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
    25. NM_001366221.1NP_001353150.1  disks large homolog 1 isoform 14

      Status: REVIEWED

      Source sequence(s)
      AC068302, AC092937
      Consensus CDS
      CCDS93448.1
      UniProtKB/TrEMBL
      A0A590UJR4, A0A590UJX2
      Related
      ENSP00000499599.1, ENST00000653795.1
      Conserved Domains (6) summary
      cd12031
      Location:499565
      SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1
      smart00228
      Location:380464
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:141225
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:642820
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:321382
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:102140
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
    26. NM_001366222.1NP_001353151.1  disks large homolog 1 isoform 15

      Status: REVIEWED

      Source sequence(s)
      AC068302, AC092937
      Consensus CDS
      CCDS93447.1
      UniProtKB/TrEMBL
      A0A590UJR4, A0A590UK48
      Related
      ENSP00000499692.1, ENST00000671246.1
      Conserved Domains (6) summary
      cd12031
      Location:499565
      SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1
      smart00228
      Location:380464
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:141225
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:630808
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:321382
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:102140
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
    27. NM_004087.2NP_004078.2  disks large homolog 1 isoform 2

      See identical proteins and their annotated locations for NP_004078.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an alternate in-frame coding exon compared to variant 1, resulting in a longer isoform (2) compared to isoform 1.
      Source sequence(s)
      AC068302, AC092937, U13896
      Consensus CDS
      CCDS3327.1
      UniProtKB/TrEMBL
      A0A590UJC5
      Related
      ENSP00000345731.2, ENST00000346964.6
      Conserved Domains (7) summary
      cd12031
      Location:582648
      SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1
      smart00228
      Location:463547
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:224308
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:735913
      Guanylate_kin; Guanylate kinase
      pfam09058
      Location:262
      L27_1
      pfam10600
      Location:404465
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:106223
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

    RNA

    1. NR_158764.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC068302, AC092937
      Related
      ENST00000660432.1
    2. NR_158765.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC068302, AC092937
      Related
      ENST00000664564.1
    3. NR_158766.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC068302, AC092937
    4. NR_158767.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC068302, AC092937
      Related
      ENST00000653331.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      197042560..197299321 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017005803.2XP_016861292.1  disks large homolog 1 isoform X1

      UniProtKB/TrEMBL
      A0A590UJC5
      Conserved Domains (7) summary
      cd12031
      Location:582648
      SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1
      smart00228
      Location:463547
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:224308
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:735913
      Guanylate_kin; Guanylate kinase
      pfam09058
      Location:262
      L27_1
      pfam10600
      Location:404465
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:106223
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
    2. XM_017005801.2XP_016861290.1  disks large homolog 1 isoform X1

      UniProtKB/TrEMBL
      A0A590UJC5
      Conserved Domains (7) summary
      cd12031
      Location:582648
      SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1
      smart00228
      Location:463547
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:224308
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:735913
      Guanylate_kin; Guanylate kinase
      pfam09058
      Location:262
      L27_1
      pfam10600
      Location:404465
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:106223
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
    3. XM_017005811.3XP_016861300.1  disks large homolog 1 isoform X3

      UniProtKB/TrEMBL
      A0A590UJ08, A0A590UJC5
      Conserved Domains (7) summary
      cd12031
      Location:531597
      SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1
      smart00228
      Location:412496
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:173257
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:684862
      Guanylate_kin; Guanylate kinase
      pfam09058
      Location:262
      L27_1
      pfam10600
      Location:353414
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:106172
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
    4. XM_011512502.4XP_011510804.1  disks large homolog 1 isoform X2

      See identical proteins and their annotated locations for XP_011510804.1

      UniProtKB/Swiss-Prot
      A5YKK7, B4DGU1, B4DGZ8, B7ZMM0, B9EIQ5, D3DXB8, D3DXB9, E7EWL7, E9PG21, Q12958, Q12959
      UniProtKB/TrEMBL
      A0A590UJR5
      Conserved Domains (7) summary
      cd12031
      Location:582648
      SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1
      smart00228
      Location:463547
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:224308
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:713891
      Guanylate_kin; Guanylate kinase
      pfam09058
      Location:262
      L27_1
      pfam10600
      Location:404465
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:106223
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
    5. XM_005269289.5XP_005269346.1  disks large homolog 1 isoform X1

      See identical proteins and their annotated locations for XP_005269346.1

      UniProtKB/TrEMBL
      A0A590UJC5
      Conserved Domains (7) summary
      cd12031
      Location:582648
      SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1
      smart00228
      Location:463547
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:224308
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:735913
      Guanylate_kin; Guanylate kinase
      pfam09058
      Location:262
      L27_1
      pfam10600
      Location:404465
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:106223
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
    6. XM_017005800.2XP_016861289.1  disks large homolog 1 isoform X1

      UniProtKB/TrEMBL
      A0A590UJC5
      Conserved Domains (7) summary
      cd12031
      Location:582648
      SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1
      smart00228
      Location:463547
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:224308
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:735913
      Guanylate_kin; Guanylate kinase
      pfam09058
      Location:262
      L27_1
      pfam10600
      Location:404465
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:106223
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
    7. XM_017005802.2XP_016861291.1  disks large homolog 1 isoform X1

      UniProtKB/TrEMBL
      A0A590UJC5
      Conserved Domains (7) summary
      cd12031
      Location:582648
      SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1
      smart00228
      Location:463547
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:224308
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:735913
      Guanylate_kin; Guanylate kinase
      pfam09058
      Location:262
      L27_1
      pfam10600
      Location:404465
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:106223
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
    8. XM_017005823.3XP_016861312.1  disks large homolog 1 isoform X5

      UniProtKB/TrEMBL
      A0A590UJR4
    9. XM_017005821.3XP_016861310.1  disks large homolog 1 isoform X4

      UniProtKB/TrEMBL
      A0A590UJR4
      Conserved Domains (7) summary
      cd12031
      Location:499565
      SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1
      smart00072
      Location:663830
      GuKc; Guanylate kinase homologues
      smart00228
      Location:380464
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:141225
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:652830
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:321382
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:102140
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
    10. XM_047447592.1XP_047303548.1  disks large homolog 1 isoform X6

      Related
      ENSP00000499280.1, ENST00000661229.1
    11. XM_047447593.1XP_047303549.1  disks large homolog 1 isoform X7

      Related
      ENSP00000376186.3, ENST00000392381.7
    12. XM_047447594.1XP_047303550.1  disks large homolog 1 isoform X8

    RNA

    1. XR_007095643.1 RNA Sequence

    2. XR_007095642.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      199768533..200020586 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054345495.1XP_054201470.1  disks large homolog 1 isoform X1

    2. XM_054345492.1XP_054201467.1  disks large homolog 1 isoform X1

    3. XM_054345497.1XP_054201472.1  disks large homolog 1 isoform X3

    4. XM_054345496.1XP_054201471.1  disks large homolog 1 isoform X2

    5. XM_054345491.1XP_054201466.1  disks large homolog 1 isoform X1

    6. XM_054345493.1XP_054201468.1  disks large homolog 1 isoform X1

    7. XM_054345494.1XP_054201469.1  disks large homolog 1 isoform X1

    8. XM_054345499.1XP_054201474.1  disks large homolog 1 isoform X5

    9. XM_054345498.1XP_054201473.1  disks large homolog 1 isoform X4

    10. XM_054345500.1XP_054201475.1  disks large homolog 1 isoform X6

    11. XM_054345501.1XP_054201476.1  disks large homolog 1 isoform X7

    12. XM_054345502.1XP_054201477.1  disks large homolog 1 isoform X8

    RNA

    1. XR_008486667.1 RNA Sequence

    2. XR_008486666.1 RNA Sequence