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    Mcm7 minichromosome maintenance complex component 7 [ Mus musculus (house mouse) ]

    Gene ID: 17220, updated on 5-Aug-2018

    Summary

    Official Symbol
    Mcm7provided by MGI
    Official Full Name
    minichromosome maintenance complex component 7provided by MGI
    Primary source
    MGI:MGI:1298398
    See related
    Ensembl:ENSMUSG00000029730 Vega:OTTMUSG00000022672
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mcmd7; mCDC47; AI747533
    Expression
    Broad expression in liver E14 (RPKM 73.1), liver E14.5 (RPKM 66.9) and 24 other tissues See more
    Orthologs

    Genomic context

    See Mcm7 in Genome Data Viewer
    Location:
    5; 5 G2
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (138164589..138171883, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (138605817..138613090, complement)

    Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene zinc finger protein 113 Neighboring gene COP9 signalosome subunit 6 Neighboring gene microRNA 106b Neighboring gene microRNA 25 Neighboring gene microRNA 93 Neighboring gene adaptor-related protein complex AP-4, mu 1 Neighboring gene TATA-box binding protein associated factor 6 Neighboring gene canopy FGF signaling regulator 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to ATP-dependent DNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
     
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to DNA helicase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    single-stranded DNA binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    DNA replication IEA
    Inferred from Electronic Annotation
    more info
     
    DNA replication initiation IEA
    Inferred from Electronic Annotation
    more info
     
    DNA unwinding involved in DNA replication IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to DNA damage stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to xenobiotic stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    MCM complex ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    DNA replication licensing factor MCM7
    Names
    CDC47 homolog
    mini chromosome maintenance deficient 7
    minichromosome maintenance deficient 7
    NP_032594.1
    XP_006504618.1
    XP_006504619.1
    XP_017176189.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356576.1NP_001343505.1  DNA replication licensing factor MCM7 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
      Source sequence(s)
      AC151719
      Conserved Domains (1) summary
      smart00350
      Location:38534
      MCM; minichromosome maintenance proteins
    2. NM_001356577.1NP_001343506.1  DNA replication licensing factor MCM7 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
      Source sequence(s)
      AC151719
      Conserved Domains (1) summary
      smart00350
      Location:38534
      MCM; minichromosome maintenance proteins
    3. NM_008568.3NP_032594.1  DNA replication licensing factor MCM7 isoform a

      See identical proteins and their annotated locations for NP_032594.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a).
      Source sequence(s)
      AC151719, AK133091
      Consensus CDS
      CCDS19793.1
      UniProtKB/Swiss-Prot
      Q61881
      UniProtKB/TrEMBL
      Q3U4T8
      Related
      ENSMUSP00000000505.9, OTTMUSP00000025921, ENSMUST00000000505.15
      Conserved Domains (3) summary
      smart00350
      Location:145641
      MCM; minichromosome maintenance proteins
      pfam14551
      Location:12165
      MCM_N; MCM N-terminal domain
      cl21455
      Location:376515
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

      Range
      138164589..138171883 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006504556.3XP_006504619.1  DNA replication licensing factor MCM7 isoform X1

      Conserved Domains (1) summary
      smart00350
      Location:38534
      MCM; minichromosome maintenance proteins
    2. XM_006504555.3XP_006504618.1  DNA replication licensing factor MCM7 isoform X1

      Conserved Domains (1) summary
      smart00350
      Location:38534
      MCM; minichromosome maintenance proteins
    3. XM_017320700.1XP_017176189.1  DNA replication licensing factor MCM7 isoform X1

      Conserved Domains (1) summary
      smart00350
      Location:38534
      MCM; minichromosome maintenance proteins

    RNA

    1. XR_001784632.1 RNA Sequence

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