Format

Send to:

Choose Destination
    • Showing Current items.

    Ascl1 achaete-scute family bHLH transcription factor 1 [ Mus musculus (house mouse) ]

    Gene ID: 17172, updated on 15-Oct-2019

    Summary

    Official Symbol
    Ascl1provided by MGI
    Official Full Name
    achaete-scute family bHLH transcription factor 1provided by MGI
    Primary source
    MGI:MGI:96919
    See related
    Ensembl:ENSMUSG00000020052
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ASH1; Mash1; bHLHa46; AI225900
    Expression
    Biased expression in CNS E11.5 (RPKM 24.4), whole brain E14.5 (RPKM 15.3) and 4 other tissues See more
    Orthologs

    Genomic context

    See Ascl1 in Genome Data Viewer
    Location:
    10; 10 C1
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    108 current GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (87490819..87493660, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (86953786..86956405, complement)

    Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC115487469 Neighboring gene U6 spliceosomal RNA Neighboring gene predicted gene, 29915 Neighboring gene phenylalanine hydroxylase

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    • Delta-Notch Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Delta-Notch Signaling Pathway, organism-specific biosystemThere are 4 Notch receptors in humans (Notch 1-4) that bind to a family of 5 ligands (Jagged 1 and 2 and Delta-like 1-3). The Notch receptors are expressed on the cell surface as heterodimeric protei...
    • Dopaminergic Neurogenesis, organism-specific biosystem (from WikiPathways)
      Dopaminergic Neurogenesis, organism-specific biosystemhttps://www.michaeljfox.org/foundation/grant-detail.php?grant_id=141
    • SIDS Susceptibility Pathways, organism-specific biosystem (from WikiPathways)
      SIDS Susceptibility Pathways, organism-specific biosystemIn this model, we provide an integrated view of Sudden Infant Death Syndrome (SIDS) at the level of implicated tissues, signaling networks and genetics. The purpose of this model is to serve as an ov...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
     
    E-box binding ISO
    Inferred from Sequence Orthology
    more info
     
    RNA polymerase II proximal promoter sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    RNA polymerase II regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    bHLH transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    Notch signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Notch signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    adrenal chromaffin cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    carotid body glomus cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell maturation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    central nervous system neuron development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    central nervous system neuron development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cerebral cortex development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    commitment of neuronal cell to specific neuron type in forebrain IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enteric nervous system development TAS
    Traceable Author Statement
    more info
    PubMed 
    forebrain neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    generation of neurons IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    glial cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    lung neuroendocrine cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    musculoskeletal movement, spinal reflex action IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    nervous system development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nervous system development ISO
    Inferred from Sequence Orthology
    more info
     
    neuroblast fate determination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neuroblast proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    neurogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neurogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    neuron development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuron development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neuron differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    neuron differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuron differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neuron fate commitment IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuron fate commitment IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    neuron fate commitment IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neuron fate specification IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuron fate specification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neuron migration IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    neuron migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    noradrenergic neuron development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    noradrenergic neuron fate commitment ISO
    Inferred from Sequence Orthology
    more info
     
    olfactory pit development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    oligodendrocyte cell fate commitment IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    oligodendrocyte development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    oligodendrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    parasympathetic nervous system development TAS
    Traceable Author Statement
    more info
    PubMed 
    pattern specification process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of Notch signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell cycle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of neural precursor cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of neurogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of Notch signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of epithelial cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of neurogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of neurogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of timing of subpallium neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    sensory organ development IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    spinal cord association neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    spinal cord oligodendrocyte cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    spinal cord oligodendrocyte cell fate specification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    stomach neuroendocrine cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    subpallium neuron fate commitment IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    sympathetic ganglion development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    sympathetic nervous system development TAS
    Traceable Author Statement
    more info
    PubMed 
    ventral spinal cord interneuron fate commitment IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    vestibular nucleus development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    RNA polymerase II transcription factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    achaete-scute homolog 1
    Names
    achaete-scute complex homolog-like 1
    achaete-scute complex-like protein 1
    mammalian achaete scute homolog 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008553.5NP_032579.2  achaete-scute homolog 1

      See identical proteins and their annotated locations for NP_032579.2

      Status: VALIDATED

      Source sequence(s)
      AK143210, BX512680
      Consensus CDS
      CCDS24101.1
      UniProtKB/Swiss-Prot
      Q02067
      Related
      ENSMUSP00000020243.7, ENSMUST00000020243.9
      Conserved Domains (1) summary
      smart00353
      Location:129171
      HLH; helix loop helix domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p6 C57BL/6J

    Genomic

    1. NC_000076.6 Reference GRCm38.p6 C57BL/6J

      Range
      87490819..87493660 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center