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    Smad6 SMAD family member 6 [ Mus musculus (house mouse) ]

    Gene ID: 17130, updated on 10-Oct-2019

    Summary

    Official Symbol
    Smad6provided by MGI
    Official Full Name
    SMAD family member 6provided by MGI
    Primary source
    MGI:MGI:1336883
    See related
    Ensembl:ENSMUSG00000036867
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Madh6; b2b390Clo
    Expression
    Biased expression in lung adult (RPKM 141.3), stomach adult (RPKM 37.6) and 11 other tissues See more
    Orthologs

    Genomic context

    See Smad6 in Genome Data Viewer
    Location:
    9; 9 C
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    108 current GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (63953076..64022085, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (63800883..63869866, complement)

    Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene ADP-ribosylation factor-like 1 pseudogene Neighboring gene predicted gene, 36033 Neighboring gene VISTA enhancer mm1518 Neighboring gene RIKEN cDNA 1700055C04 gene Neighboring gene VISTA enhancer mm69

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (1)  1 citation
    • Chemically induced (ENU) (1) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    I-SMAD binding ISO
    Inferred from Sequence Orthology
    more info
     
    R-SMAD binding ISO
    Inferred from Sequence Orthology
    more info
     
    RNA polymerase II proximal promoter sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    co-SMAD binding ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcription regulatory region DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity ISO
    Inferred from Sequence Orthology
    more info
     
    type I activin receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    type I transforming growth factor beta receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    BMP signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    aorta development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    aortic valve morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    cardiac vascular smooth muscle cell development TAS
    Traceable Author Statement
    more info
    PubMed 
    cell-substrate adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    coronary vasculature development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    coronary vasculature morphogenesis TAS
    Traceable Author Statement
    more info
    PubMed 
    fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    heart valve development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    immune response ISO
    Inferred from Sequence Orthology
    more info
     
    mitral valve morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of BMP signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of SMAD protein complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of blood vessel diameter TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of ossification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of osteoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of pathway-restricted SMAD protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    outflow tract septum morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of pri-miRNA transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of vasoconstriction TAS
    Traceable Author Statement
    more info
    PubMed 
    pulmonary valve morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    response to lipopolysaccharide ISO
    Inferred from Sequence Orthology
    more info
     
    transforming growth factor beta receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    ureteric bud development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    ventricular septum development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    zygotic specification of dorsal/ventral axis ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    transcription factor complex IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    mothers against decapentaplegic homolog 6
    Names
    MAD homolog 6
    Smad 6
    mad homolog 7
    mothers against DPP homolog 6

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008542.3NP_032568.3  mothers against decapentaplegic homolog 6

      See identical proteins and their annotated locations for NP_032568.3

      Status: VALIDATED

      Source sequence(s)
      AC114674, AC135672, AI415735, AK046602
      Consensus CDS
      CCDS23273.1
      UniProtKB/Swiss-Prot
      O35182
      Related
      ENSMUSP00000036285.5, ENSMUST00000041029.5
      Conserved Domains (2) summary
      cd10493
      Location:161274
      MH1_SMAD_6; N-terminal Mad Homology 1 (MH1) domain in SMAD6
      cd10499
      Location:323493
      MH2_SMAD_6; C-terminal Mad Homology 2 (MH2) domain in SMAD6

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p6 C57BL/6J

    Genomic

    1. NC_000075.6 Reference GRCm38.p6 C57BL/6J

      Range
      63953076..64022085 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006510822.3XP_006510885.1  mothers against decapentaplegic homolog 6 isoform X1

      See identical proteins and their annotated locations for XP_006510885.1

      UniProtKB/Swiss-Prot
      O35182
      Conserved Domains (2) summary
      cd10493
      Location:161274
      MH1_SMAD_6; N-terminal Mad Homology 1 (MH1) domain in SMAD6
      cd10499
      Location:323493
      MH2_SMAD_6; C-terminal Mad Homology 2 (MH2) domain in SMAD6
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