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    Pou2f1 POU class 2 homeobox 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 171068, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Pou2f1provided by RGD
    Official Full Name
    POU class 2 homeobox 1provided by RGD
    Primary source
    RGD:621689
    See related
    Ensembl:ENSRNOG00000003581 AllianceGenome:RGD:621689
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables chromatin binding activity; signaling receptor binding activity; and transcription cis-regulatory region binding activity. Involved in liver regeneration and negative regulation of gene expression. Located in nucleus. Orthologous to human POU2F1 (POU class 2 homeobox 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 59.6), Spleen (RPKM 48.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    13q23
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (80653602..80796279, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (78120617..78263306, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (84075316..84217368, complement)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene cellular repressor of E1A-stimulated genes 1 Neighboring gene Cd247 molecule Neighboring gene uncharacterized LOC134481526 Neighboring gene serine/threonine/tyrosine interacting like 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Regulation of the rat CYP4A2 gene promoter by c-Jun and octamer binding protein-1. Fiala-Beer E, et al. Int J Biochem Cell Biol, 2007. PMID 17481938
    2. Oct-1 transcription factor is a negative regulator of rat CYP1A1 expression via an octamer sequence in its negative regulatory element. Sterling K, et al. Mol Pharmacol, 1996 Feb. PMID 8632766
    3. The POU-domain protein Oct-1 is widely expressed in adult rat organs. Kambe F, et al. Biochim Biophys Acta, 1993 Jan 23. PMID 8424955
    4. Rat DNA sequence associated with a complex form of DNA polymerase alpha in nonregenerating liver interacts with a ubiquitous transcription/replication factor Oct-1. Timchenko NA, et al. Biomed Sci, 1991. PMID 1841628
    5. Cloning and sequencing of the rat Oct-1 POU box. Lillycrop KA, et al. Nucleic Acids Res, 1991 Jul 11. PMID 1677182, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. POU2F1/DNMT3a Pathway Participates in Neuropathic Pain by Hypermethylation-Mediated LRFN4 Downregulation Following Oxaliplatin Treatment.
      Title: POU2F1/DNMT3a Pathway Participates in Neuropathic Pain by Hypermethylation-Mediated LRFN4 Downregulation Following Oxaliplatin Treatment.
    2. Data show that cAMP elevation reduces nuclear Oct-1 content in primary pancreatic islet cells.
      Title: POU homeodomain protein Oct-1 functions as a sensor for cyclic AMP.
    3. acts as the activator of the CYP2D4
      Title: A novel transcriptional element which regulates expression of the CYP2D4 gene by Oct-1 and YY-1 binding.
    4. Oct-1 and the TALE homeodomain proteins have roles in regulating the expression of the GnRH gene in neurons
      Title: TALE homeodomain proteins regulate gonadotropin-releasing hormone gene expression independently and via interactions with Oct-1.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II core promoter sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II core promoter sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables signaling receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within lens induction in camera-type eye ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in liver regeneration IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within olfactory placode formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of RNA polymerase II transcription regulator complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of RNA polymerase II transcription regulator complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription regulator complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    POU domain, class 2, transcription factor 1
    Names
    NF-A1
    OTF-1
    oct-1
    octamer-binding protein 1
    octamer-binding transcription factor 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100639.1 → NP_001094109.1  POU domain, class 2, transcription factor 1

      See identical proteins and their annotated locations for NP_001094109.1

      Status: VALIDATED

      Source sequence(s)
      DV214198, U17013
      UniProtKB/TrEMBL
      A6IDI7, F1LRD7
      Related
      ENSRNOP00000044416.5, ENSRNOT00000047488.6
      Conserved Domains (2) summary
      smart00352
      Location:303 → 377
      POU; Found in Pit-Oct-Unc transcription factors
      pfam00046
      Location:407 → 460
      Homeobox; Homeobox domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      80653602..80796279 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008769599.4 → XP_008767821.1  POU domain, class 2, transcription factor 1 isoform X2

      See identical proteins and their annotated locations for XP_008767821.1

      UniProtKB/TrEMBL
      A0A0G2K3N5, A6IDI6, F1LRD7
      Related
      ENSRNOP00000072711.1
      Conserved Domains (2) summary
      smart00352
      Location:303 → 377
      POU; Found in Pit-Oct-Unc transcription factors
      pfam00046
      Location:407 → 461
      Homeobox; Homeobox domain

    2. XM_039090304.2 → XP_038946232.1  POU domain, class 2, transcription factor 1 isoform X3

      UniProtKB/TrEMBL
      F1LRD7
      Conserved Domains (2) summary
      smart00352
      Location:280 → 354
      POU; Found in Pit-Oct-Unc transcription factors
      pfam00046
      Location:384 → 438
      Homeobox; Homeobox domain

    3. XM_039090301.2 → XP_038946229.1  POU domain, class 2, transcription factor 1 isoform X3

      UniProtKB/TrEMBL
      F1LRD7
      Conserved Domains (2) summary
      smart00352
      Location:280 → 354
      POU; Found in Pit-Oct-Unc transcription factors
      pfam00046
      Location:384 → 438
      Homeobox; Homeobox domain

    4. XM_017598656.3 → XP_017454145.1  POU domain, class 2, transcription factor 1 isoform X3

      UniProtKB/TrEMBL
      F1LRD7
      Conserved Domains (2) summary
      smart00352
      Location:280 → 354
      POU; Found in Pit-Oct-Unc transcription factors
      pfam00046
      Location:384 → 438
      Homeobox; Homeobox domain

    5. XM_039090298.2 → XP_038946226.1  POU domain, class 2, transcription factor 1 isoform X3

      UniProtKB/TrEMBL
      F1LRD7
      Conserved Domains (2) summary
      smart00352
      Location:280 → 354
      POU; Found in Pit-Oct-Unc transcription factors
      pfam00046
      Location:384 → 438
      Homeobox; Homeobox domain

    6. XM_063271991.1 → XP_063128061.1  POU domain, class 2, transcription factor 1 isoform X4

    7. XM_063271989.1 → XP_063128059.1  POU domain, class 2, transcription factor 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AEY3, A6IDI8

    8. XM_063271990.1 → XP_063128060.1  POU domain, class 2, transcription factor 1 isoform X3

    RNA

    1. XR_005492198.2 RNA Sequence

    2. XR_005492197.2 RNA Sequence

    3. XR_595497.4 RNA Sequence

    4. XR_005492196.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P31503.2 GenPept UniProtKB/Swiss-Prot:P31503

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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