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    Il1rl1 interleukin 1 receptor-like 1 [ Mus musculus (house mouse) ]

    Gene ID: 17082, updated on 1-Jul-2024

    Summary

    Official Symbol
    Il1rl1provided by MGI
    Official Full Name
    interleukin 1 receptor-like 1provided by MGI
    Primary source
    MGI:MGI:98427
    See related
    Ensembl:ENSMUSG00000026069 AllianceGenome:MGI:98427
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    T1; St2; DER4; Ly84; ST2L; Fit-1; T1/ST2; St2-rs1
    Summary
    Enables interleukin-33 binding activity and interleukin-33 receptor activity. Involved in several processes, including negative regulation of T-helper 1 type immune response; positive regulation of macrophage activation; and regulation of cytokine production. Acts upstream of or within negative regulation of I-kappaB kinase/NF-kappaB signaling. Located in external side of plasma membrane and extracellular matrix. Is expressed in several structures, including immune system; musculoskeletal system; salivary gland; skin; and visual system. Human ortholog(s) of this gene implicated in asthma and coronary artery disease. Orthologous to human IL1RL1 (interleukin 1 receptor like 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in liver E14.5 (RPKM 1.3), liver E14 (RPKM 1.3) and 16 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Il1rl1 in Genome Data Viewer
    Location:
    1 B; 1 19.19 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (40444105..40504575)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (40404864..40465418)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene interleukin 1 receptor, type I Neighboring gene STARR-positive B cell enhancer ABC_E5749 Neighboring gene STARR-seq mESC enhancer starr_00738 Neighboring gene interleukin 1 receptor-like 2 Neighboring gene ribosomal protein 10 pseudogene Neighboring gene STARR-seq mESC enhancer starr_00741 Neighboring gene interleukin 18 receptor 1 Neighboring gene interleukin 18 receptor accessory protein

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (12) 
    • Targeted (8)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables NAD+ nucleotidase, cyclic ADP-ribose generating IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables interleukin-1 receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables interleukin-33 binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables interleukin-33 binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables interleukin-33 receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in focal adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    interleukin-1 receptor-like 1
    Names
    interleukin-33 receptor alpha chain
    lymphocyte antigen 84
    NP_001020773.1
    NP_001281100.1
    NP_001407277.1
    NP_001407278.1
    NP_001407279.1
    NP_001407280.1
    NP_034873.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025602.4NP_001020773.1  interleukin-1 receptor-like 1 isoform a precursor

      See identical proteins and their annotated locations for NP_001020773.1

      Status: VALIDATED

      Source sequence(s)
      AC167126, AC167168
      Consensus CDS
      CCDS35548.1
      UniProtKB/Swiss-Prot
      P14719, Q05208
      UniProtKB/TrEMBL
      Q3UM53
      Related
      ENSMUSP00000095379.4, ENSMUST00000097772.10
      Conserved Domains (4) summary
      pfam01582
      Location:385540
      TIR; TIR domain
      cd00096
      Location:3742
      Ig; Ig strand B [structural motif]
      cd05757
      Location:124210
      Ig2_IL1R-like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains
      cl11960
      Location:3397
      Ig; Immunoglobulin domain
    2. NM_001294171.2NP_001281100.1  interleukin-1 receptor-like 1 isoform b precursor

      See identical proteins and their annotated locations for NP_001281100.1

      Status: VALIDATED

      Source sequence(s)
      AC167126, AC167168
      Consensus CDS
      CCDS56626.1
      UniProtKB/TrEMBL
      Q5D095
      Related
      ENSMUSP00000134351.2, ENSMUST00000174335.8
      Conserved Domains (3) summary
      cd05757
      Location:124210
      Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
      smart00410
      Location:27110
      IG_like; Immunoglobulin like
      cl11960
      Location:27110
      Ig; Immunoglobulin domain
    3. NM_001420348.1NP_001407277.1  interleukin-1 receptor-like 1 isoform a precursor

      Status: VALIDATED

      Source sequence(s)
      AC167126, AC167168
      UniProtKB/Swiss-Prot
      P14719, Q05208
      UniProtKB/TrEMBL
      Q3UM53
      Related
      ENSMUSP00000054914.8, ENSMUST00000053043.8
    4. NM_001420349.1NP_001407278.1  interleukin-1 receptor-like 1 isoform a precursor

      Status: VALIDATED

      Source sequence(s)
      AC167126, AC167168
      UniProtKB/Swiss-Prot
      P14719, Q05208
      UniProtKB/TrEMBL
      Q3UM53
    5. NM_001420350.1NP_001407279.1  interleukin-1 receptor-like 1 isoform a precursor

      Status: VALIDATED

      Source sequence(s)
      AC167126, AC167168
      UniProtKB/Swiss-Prot
      P14719, Q05208
      UniProtKB/TrEMBL
      Q3UM53
    6. NM_001420351.1NP_001407280.1  interleukin-1 receptor-like 1 isoform b precursor

      Status: VALIDATED

      Source sequence(s)
      AC167126, AC167168
      UniProtKB/TrEMBL
      Q3UM53
    7. NM_010743.4NP_034873.2  interleukin-1 receptor-like 1 isoform b precursor

      See identical proteins and their annotated locations for NP_034873.2

      Status: VALIDATED

      Source sequence(s)
      AC167126, AC167168
      Consensus CDS
      CCDS56626.1
      UniProtKB/TrEMBL
      Q5D095
      Related
      ENSMUSP00000133784.2, ENSMUST00000173514.8
      Conserved Domains (3) summary
      cd05757
      Location:124210
      Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
      smart00410
      Location:27110
      IG_like; Immunoglobulin like
      cl11960
      Location:27110
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      40444105..40504575
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)