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    TLE5 TLE family member 5, transcriptional modulator [ Homo sapiens (human) ]

    Gene ID: 166, updated on 7-Apr-2024

    Summary

    Official Symbol
    TLE5provided by HGNC
    Official Full Name
    TLE family member 5, transcriptional modulatorprovided by HGNC
    Primary source
    HGNC:HGNC:307
    See related
    Ensembl:ENSG00000104964 MIM:600188; AllianceGenome:HGNC:307
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AES; GRG; ESP1; GRG5; AES-1; AES-2; Grg-5
    Summary
    The protein encoded by this gene is similar in sequence to the amino terminus of Drosophila enhancer of split groucho, a protein involved in neurogenesis during embryonic development. The encoded protein, which belongs to the groucho/TLE family of proteins, can function as a homooligomer or as a heteroologimer with other family members to dominantly repress the expression of other family member genes. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in heart (RPKM 135.6), spleen (RPKM 116.8) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See TLE5 in Genome Data Viewer
    Location:
    19p13.3
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (3052910..3062966, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (3026363..3036419, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (3052908..3062964, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9819 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:2982456-2982974 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:2982975-2983491 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr19:2984010-2984526 Neighboring gene TLE family member 6, subcortical maternal complex member Neighboring gene ReSE screen-validated silencer GRCh37_chr19:3003179-3003325 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:3006113-3007047 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:3007156-3007353 Neighboring gene TLE family member 2, transcriptional corepressor Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13724 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9820 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9821 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:3041680-3041803 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:3054606-3055171 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:3057431-3057995 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:3057996-3058560 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:3059514-3059717 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9822 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9823 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9824 Neighboring gene uncharacterized LOC105372242 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:3066867-3067075 Neighboring gene Sharpr-MPRA regulatory region 11171 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:3076432-3076689 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:3094165-3095152 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:3095153-3096138 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:3096139-3097126 Neighboring gene Sharpr-MPRA regulatory region 3290 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9829 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9830 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:3107873-3108374 Neighboring gene G protein subunit alpha 11

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of amino-terminal enhancer of split (AES) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed
    Knockdown of amino-terminal enhancer of split (AES) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription corepressor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transcription corepressor activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    TLE family member 5
    Names
    amino-terminal enhancer of split
    gp130-associated protein GAM
    groucho-related protein 5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029870.1 RefSeqGene

      Range
      5472..15057
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001130.6NP_001121.2  TLE family member 5 isoform b

      See identical proteins and their annotated locations for NP_001121.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding region compared to variant 1. The resulting isoform (b) is shorter and has a distinct N-terminus compared to isoform a.
      Source sequence(s)
      AC005944, AF269289, AK094591, BM550097, BM908356
      Consensus CDS
      CCDS12102.1
      UniProtKB/Swiss-Prot
      B2RBL0, Q08117, Q12808, Q14CJ1, Q96TG9, Q9UDY9
      Related
      ENSP00000317537.4, ENST00000327141.9
      Conserved Domains (1) summary
      pfam03920
      Location:11132
      TLE_N; Groucho/TLE N-terminal Q-rich domain
    2. NM_198969.1NP_945320.1  TLE family member 5 isoform a

      See identical proteins and their annotated locations for NP_945320.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AF269289, AK094591, BG913049, N23852
      Consensus CDS
      CCDS12101.1
      UniProtKB/Swiss-Prot
      Q08117
      UniProtKB/TrEMBL
      Q8WY48
      Related
      ENSP00000221561.7, ENST00000221561.12
      Conserved Domains (1) summary
      pfam03920
      Location:72199
      TLE_N; Groucho/TLE N-terminal Q-rich domain
    3. NM_198970.2NP_945321.1  TLE family member 5 isoform c

      See identical proteins and their annotated locations for NP_945321.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding region compared to variant 1. The resulting isoform (c) is shorter, has a distinct N-terminus, and lacks 1 aa in the C-terminus compared to isoform a.
      Source sequence(s)
      AC005944, AF269289, AK094591, BG696926, BM908356
      UniProtKB/Swiss-Prot
      Q08117
      UniProtKB/TrEMBL
      Q8WY48
      Conserved Domains (1) summary
      pfam03920
      Location:11131
      TLE_N; Groucho/TLE N-terminal Q-rich domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      3052910..3062966 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006722664.2XP_006722727.1  TLE family member 5 isoform X1

      Conserved Domains (1) summary
      pfam03920
      Location:72198
      TLE_N; Groucho/TLE N-terminal Q-rich domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      3026363..3036419 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054320108.1XP_054176083.1  TLE family member 5 isoform X1