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    PARP15 poly(ADP-ribose) polymerase family member 15 [ Homo sapiens (human) ]

    Gene ID: 165631, updated on 17-Jun-2019

    Summary

    Official Symbol
    PARP15provided by HGNC
    Official Full Name
    poly(ADP-ribose) polymerase family member 15provided by HGNC
    Primary source
    HGNC:HGNC:26876
    See related
    Ensembl:ENSG00000173200 MIM:612066
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BAL3; ARTD7; pART7
    Summary
    PARP15 is a macrodomain-containing transcriptional repressor with poly(ADP-ribose) polymerase activity (Aguiar et al., 2005 [PubMed 16061477]).[supplied by OMIM, May 2008]
    Expression
    Biased expression in spleen (RPKM 9.7), lymph node (RPKM 8.3) and 8 other tissues See more
    Orthologs

    Genomic context

    See PARP15 in Genome Data Viewer
    Location:
    3q21.1
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (122575926..122639047)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (122296435..122357894)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374071 Neighboring gene poly(ADP-ribose) polymerase family member 9 Neighboring gene deltex E3 ubiquitin ligase 3L Neighboring gene poly(ADP-ribose) polymerase family member 14 pseudogene Neighboring gene eukaryotic translation initiation factor 4B pseudogene 8 Neighboring gene poly(ADP-ribose) polymerase family member 14

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    A mega-analysis of genome-wide association studies for major depressive disorder.
    NHGRI GWA Catalog
    Genome-wide association study of chronic periodontitis in a general German population.
    NHGRI GWA Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ40196, FLJ40597, MGC126750, MGC126752

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    NAD+ ADP-ribosyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NAD+ binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein ADP-ribosylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcription corepressor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein poly-ADP-ribosylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    nucleus IC
    Inferred by Curator
    more info
    PubMed 

    General protein information

    Preferred Names
    protein mono-ADP-ribosyltransferase PARP15
    Names
    ADP-ribosyltransferase diphtheria toxin-like 7
    B-aggressive lymphoma 3
    B-aggressive lymphoma protein 3
    PARP-15
    poly [ADP-ribose] polymerase 15
    NP_001106995.1
    NP_001295249.1
    NP_001295250.1
    NP_689828.1
    XP_005247216.1
    XP_005247217.1
    XP_011510777.1
    XP_011510778.1
    XP_011510779.1
    XP_011510780.1
    XP_011510781.1
    XP_011510782.1
    XP_016861280.1
    XP_016861281.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001113523.3NP_001106995.1  protein mono-ADP-ribosyltransferase PARP15 isoform 1

      See identical proteins and their annotated locations for NP_001106995.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC092908, AK097916, AK309863, BC101701, BX647656, DQ063586
      Consensus CDS
      CCDS46893.1
      UniProtKB/Swiss-Prot
      Q460N3
      Related
      ENSP00000417214.2, ENST00000464300.7
      Conserved Domains (4) summary
      COG2110
      Location:88260
      YmdB; O-acetyl-ADP-ribose deacetylase (regulator of RNase III), contains Macro domain [Translation, ribosomal structure and biogenesis]
      cd01439
      Location:556676
      TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
      cd02903
      Location:89230
      Macro_BAL_like; Macro domain, BAL_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). ...
      pfam00644
      Location:499676
      PARP; Poly(ADP-ribose) polymerase catalytic domain
    2. NM_001308320.2NP_001295249.1  protein mono-ADP-ribosyltransferase PARP15 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks three alternate in-frame coding exons and uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (3) is shorter compared to isoform 1.
      Source sequence(s)
      AC092908, AK097916, BX647656
      Consensus CDS
      CCDS77803.1
      UniProtKB/Swiss-Prot
      Q460N3
      UniProtKB/TrEMBL
      C9J7L3
      Related
      ENSP00000417785.1, ENST00000483793.5
      Conserved Domains (3) summary
      cd01439
      Location:361481
      TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
      pfam00644
      Location:304481
      PARP; Poly(ADP-ribose) polymerase catalytic domain
      cl00019
      Location:181287
      Macro; Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly ...
    3. NM_001308321.1NP_001295250.1  protein mono-ADP-ribosyltransferase PARP15 isoform 4 precursor

      See identical proteins and their annotated locations for NP_001295250.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and 5' coding region, resulting in the presence of a novel 5' coding region and start codon, compared to variant 1. The encoded isoform (4) has a shorter distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AC092908, BC143573, BX647656
      Consensus CDS
      CCDS77804.1
      UniProtKB/TrEMBL
      B7ZL48
      Related
      ENSP00000419488.1, ENST00000493645.1
      Conserved Domains (3) summary
      cd01439
      Location:253373
      TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
      pfam00644
      Location:196373
      PARP; Poly(ADP-ribose) polymerase catalytic domain
      cl00019
      Location:70179
      Macro; Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly ...
    4. NM_152615.2NP_689828.1  protein mono-ADP-ribosyltransferase PARP15 isoform 2 precursor

      See identical proteins and their annotated locations for NP_689828.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and has multiple coding region differences, compared to variant 1, one of which results in the presence of a novel 5' coding region and start codon. The encoded isoform (2) has a shorter distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AC092908, AK097916, BC101701, BX647656
      Consensus CDS
      CCDS3016.1
      UniProtKB/Swiss-Prot
      Q460N3
      Related
      ENSP00000308436.4, ENST00000310366.8
      Conserved Domains (2) summary
      cd01439
      Location:322442
      TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
      cd02903
      Location:70197
      Macro_BAL_like; Macro domain, BAL_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

      Range
      122575926..122639047
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011512475.3XP_011510777.1  protein mono-ADP-ribosyltransferase PARP15 isoform X1

      Conserved Domains (3) summary
      cd01439
      Location:516636
      TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
      cd02903
      Location:63190
      Macro_BAL_like; Macro domain, BAL_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). ...
      pfam00644
      Location:459636
      PARP; Poly(ADP-ribose) polymerase catalytic domain
    2. XM_005247159.4XP_005247216.1  protein mono-ADP-ribosyltransferase PARP15 isoform X3

      Conserved Domains (5) summary
      COG2110
      Location:88260
      YmdB; O-acetyl-ADP-ribose deacetylase (regulator of RNase III), contains Macro domain [Translation, ribosomal structure and biogenesis]
      cd01439
      Location:487607
      TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
      cd02903
      Location:89230
      Macro_BAL_like; Macro domain, BAL_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). ...
      pfam00644
      Location:430607
      PARP; Poly(ADP-ribose) polymerase catalytic domain
      cl00019
      Location:304413
      Macro; Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly ...
    3. XM_011512476.3XP_011510778.1  protein mono-ADP-ribosyltransferase PARP15 isoform X2

      Conserved Domains (4) summary
      COG2110
      Location:88258
      YmdB; O-acetyl-ADP-ribose deacetylase (regulator of RNase III), contains Macro domain [Translation, ribosomal structure and biogenesis]
      cd01439
      Location:506626
      TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
      cd02903
      Location:89230
      Macro_BAL_like; Macro domain, BAL_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). ...
      pfam00644
      Location:449626
      PARP; Poly(ADP-ribose) polymerase catalytic domain
    4. XM_005247160.4XP_005247217.1  protein mono-ADP-ribosyltransferase PARP15 isoform X4

      Conserved Domains (4) summary
      cd01439
      Location:480600
      TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
      cd02903
      Location:228355
      Macro_BAL_like; Macro domain, BAL_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). ...
      pfam00644
      Location:423600
      PARP; Poly(ADP-ribose) polymerase catalytic domain
      cl00019
      Location:91181
      Macro; Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly ...
    5. XM_017005791.2XP_016861280.1  protein mono-ADP-ribosyltransferase PARP15 isoform X6

    6. XM_011512477.3XP_011510779.1  protein mono-ADP-ribosyltransferase PARP15 isoform X5

      Conserved Domains (4) summary
      cd01439
      Location:430550
      TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
      cd02903
      Location:181305
      Macro_BAL_like; Macro domain, BAL_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). ...
      pfam00644
      Location:373550
      PARP; Poly(ADP-ribose) polymerase catalytic domain
      cl00019
      Location:91183
      Macro; Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly ...
    7. XM_011512480.3XP_011510782.1  protein mono-ADP-ribosyltransferase PARP15 isoform X8

      Conserved Domains (3) summary
      COG2110
      Location:88260
      YmdB; O-acetyl-ADP-ribose deacetylase (regulator of RNase III), contains Macro domain [Translation, ribosomal structure and biogenesis]
      cd02903
      Location:89230
      Macro_BAL_like; Macro domain, BAL_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). ...
      cl00019
      Location:304352
      Macro; Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly ...
    8. XM_011512478.3XP_011510780.1  protein mono-ADP-ribosyltransferase PARP15 isoform X7

      See identical proteins and their annotated locations for XP_011510780.1

      Conserved Domains (3) summary
      cd01439
      Location:303423
      TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
      cd02903
      Location:51178
      Macro_BAL_like; Macro domain, BAL_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). ...
      pfam00644
      Location:246423
      PARP; Poly(ADP-ribose) polymerase catalytic domain
    9. XM_011512479.3XP_011510781.1  protein mono-ADP-ribosyltransferase PARP15 isoform X7

      See identical proteins and their annotated locations for XP_011510781.1

      Conserved Domains (3) summary
      cd01439
      Location:303423
      TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
      cd02903
      Location:51178
      Macro_BAL_like; Macro domain, BAL_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). ...
      pfam00644
      Location:246423
      PARP; Poly(ADP-ribose) polymerase catalytic domain
    10. XM_017005792.2XP_016861281.1  protein mono-ADP-ribosyltransferase PARP15 isoform X7

      Conserved Domains (3) summary
      cd01439
      Location:303423
      TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
      cd02903
      Location:51178
      Macro_BAL_like; Macro domain, BAL_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). ...
      pfam00644
      Location:246423
      PARP; Poly(ADP-ribose) polymerase catalytic domain
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