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    Irx1 Iroquois homeobox 1 [ Mus musculus (house mouse) ]

    Gene ID: 16371, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Irx1provided by MGI
    Official Full Name
    Iroquois homeobox 1provided by MGI
    Primary source
    MGI:MGI:1197515
    See related
    Ensembl:ENSMUSG00000060969 AllianceGenome:MGI:1197515
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within proximal/distal pattern formation involved in metanephric nephron development and specification of loop of Henle identity. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; autopod; central nervous system; genitourinary system; and sensory organ. Orthologous to human IRX1 (iroquois homeobox 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in lung adult (RPKM 102.7), mammary gland adult (RPKM 39.1) and 8 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Irx1 in Genome Data Viewer
    Location:
    13 C1; 13 38.43 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (72106351..72111842, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (71958232..71963723, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700112M02 gene Neighboring gene STARR-seq mESC enhancer starr_34966 Neighboring gene STARR-seq mESC enhancer starr_34967 Neighboring gene STARR-seq mESC enhancer starr_34968 Neighboring gene predicted gene, 40999 Neighboring gene STARR-seq mESC enhancer starr_34970 Neighboring gene STARR-seq mESC enhancer starr_34971 Neighboring gene STARR-seq mESC enhancer starr_34973 Neighboring gene STARR-seq mESC enhancer starr_34974 Neighboring gene STARR-seq mESC enhancer starr_34975 Neighboring gene STARR-seq mESC enhancer starr_34976 Neighboring gene STARR-seq mESC enhancer starr_34977 Neighboring gene STARR-seq mESC enhancer starr_34979 Neighboring gene predicted gene 4052 Neighboring gene ribosomal protein L9, pseudogene 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. IRX1 ameliorates sepsis-induced acute kidney injury in mice by promoting CXCL14. Zhang J, et al. Allergol Immunopathol (Madr), 2022. PMID 36335463
    2. Sodium channel mutations in acetazolamide-responsive myotonia congenita, paramyotonia congenita, and hyperkalemic periodic paralysis. Ptáĉek LJ, et al. Neurology, 1994 Aug. PMID 8058156
    3. Identification of the vertebrate Iroquois homeobox gene family with overlapping expression during early development of the nervous system. Bosse A, et al. Mech Dev, 1997 Dec. PMID 9486539
    4. Iroquois genes influence proximo-distal morphogenesis during rat lung development. van Tuyl M, et al. Am J Physiol Lung Cell Mol Physiol, 2006 Apr. PMID 16299054
    5. Expression pattern of Irx1 and Irx2 during mouse digit development. Zülch A, et al. Mech Dev, 2001 Aug. PMID 11472848

    See all (75) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. IRX1 ameliorates sepsis-induced acute kidney injury in mice by promoting CXCL14.
      Title: IRX1 ameliorates sepsis-induced acute kidney injury in mice by promoting CXCL14.
    2. Irx1 regulates Foxj1 and Sox9 to control cell differentiation during development.
      Title: Irx1 regulates dental outer enamel epithelial and lung alveolar type II epithelial differentiation.
    3. This homeobox protein is expressed during digit development and is an early marker for this development.
      Title: Expression pattern of Irx1 and Irx2 during mouse digit development.
    4. This homeobox protein is expressed during early lung development.
      Title: Irx1 and Irx2 expression in early lung development.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in metanephros development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neuron differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proximal/distal pattern formation involved in metanephric nephron development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to organic cyclic compound ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in specification of loop of Henle identity IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    iroquois-class homeodomain protein IRX-1
    Names
    Iroquois related homeobox 1
    homeodomain protein IRXA1
    iroquois homeobox protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010573.2 → NP_034703.2  iroquois-class homeodomain protein IRX-1

      See identical proteins and their annotated locations for NP_034703.2

      Status: VALIDATED

      Source sequence(s)
      AK133937, AW491133, CO043226
      Consensus CDS
      CCDS26627.1
      UniProtKB/Swiss-Prot
      G5E8H6, O55120, P81068, Q3UZB9, Q9JLL6
      Related
      ENSMUSP00000076562.9, ENSMUST00000077337.9
      Conserved Domains (3) summary
      smart00548
      Location:309 → 326
      IRO; Motif in Iroquois-class homeodomain proteins (only). Unknown function
      pfam05285
      Location:194 → 252
      SDA1; SDA1
      pfam05920
      Location:145 → 184
      Homeobox_KN; Homeobox KN domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      72106351..72111842 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036157861.1 → XP_036013754.1  iroquois-class homeodomain protein IRX-1 isoform X1

      Conserved Domains (3) summary
      smart00548
      Location:148 → 165
      IRO; Motif in Iroquois-class homeodomain proteins (only). Unknown function
      cl00084
      Location:1 → 23
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      cl01319
      Location:27 → 86
      HARE-HTH; HB1, ASXL, restriction endonuclease HTH domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P81068.4 GenPept UniProtKB/Swiss-Prot:P81068

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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