Format

Send to:

Choose Destination
    • Showing Current items.

    TDRD5 tudor domain containing 5 [ Homo sapiens (human) ]

    Gene ID: 163589, updated on 17-Jun-2019

    Summary

    Official Symbol
    TDRD5provided by HGNC
    Official Full Name
    tudor domain containing 5provided by HGNC
    Primary source
    HGNC:HGNC:20614
    See related
    Ensembl:ENSG00000162782 MIM:617748
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TUDOR3
    Expression
    Restricted expression toward testis (RPKM 11.6) See more
    Orthologs

    Genomic context

    See TDRD5 in Genome Data Viewer
    Location:
    1q25.2
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (179591613..179691272)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (179560748..179660407)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene RNA, U5F small nuclear 2, pseudogene Neighboring gene ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 pseudogene Neighboring gene uncharacterized LOC105371635 Neighboring gene family with sequence similarity 163 member A Neighboring gene uncharacterized LOC105371634 Neighboring gene microRNA 12116

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ34823, MGC163404

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    DNA methylation involved in gamete generation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    P granule organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    spermatid development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    chromatoid body ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    pi-body ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    tudor domain-containing protein 5
    Names
    testicular tissue protein Li 194

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_053092.1 RefSeqGene

      Range
      5001..104660
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001199085.3NP_001186014.1  tudor domain-containing protein 5 isoform 1

      See identical proteins and their annotated locations for NP_001186014.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Variants 1 and 2 both encode the same isoform (1).
      Source sequence(s)
      AK127370, BC089387, BC144058, DA418635
      Consensus CDS
      CCDS55663.1
      UniProtKB/Swiss-Prot
      Q8NAT2
      Related
      ENSP00000406052.1, ENST00000444136.6
      Conserved Domains (5) summary
      cd04508
      Location:529575
      TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
      cd09975
      Location:132201
      LOTUS_2_TDRD5; The second LOTUS domain on Tudor-containing protein 5 (TDRD5)
      cd09976
      Location:296369
      LOTUS_3_TDRD5; The third LOTUS domain on Tudor-containing protein 5 (TDRD5)
      cd09985
      Location:498
      LOTUS_1_TDRD5; The first LOTUS domain on Tudor-containing protein 5 (TDRD5)
      pfam00567
      Location:471594
      TUDOR; Tudor domain
    2. NM_001199089.3NP_001186018.1  tudor domain-containing protein 5 isoform 1

      See identical proteins and their annotated locations for NP_001186018.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (1).
      Source sequence(s)
      AK127370, BC043368, BC089387, BC130532, DA418635, DB073297
      Consensus CDS
      CCDS55663.1
      UniProtKB/Swiss-Prot
      Q8NAT2
      Conserved Domains (5) summary
      cd04508
      Location:529575
      TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
      cd09975
      Location:132201
      LOTUS_2_TDRD5; The second LOTUS domain on Tudor-containing protein 5 (TDRD5)
      cd09976
      Location:296369
      LOTUS_3_TDRD5; The third LOTUS domain on Tudor-containing protein 5 (TDRD5)
      cd09985
      Location:498
      LOTUS_1_TDRD5; The first LOTUS domain on Tudor-containing protein 5 (TDRD5)
      pfam00567
      Location:471594
      TUDOR; Tudor domain
    3. NM_001199091.1NP_001186020.1  tudor domain-containing protein 5 isoform 2

      See identical proteins and their annotated locations for NP_001186020.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and lacks an in-frame coding exon compared to variant 1. The resulting isoform (2) lacks an internal segment compared to isoform 1. Variants 3, 4, and 6 all encode the same isoform (2).
      Source sequence(s)
      AK126889, AL160286, BC043368, BC089387
      Consensus CDS
      CCDS1332.1
      UniProtKB/Swiss-Prot
      Q8NAT2
      UniProtKB/TrEMBL
      A0A024R910
      Related
      ENSP00000356586.1, ENST00000367614.5
      Conserved Domains (4) summary
      cd09975
      Location:132201
      LOTUS_2_TDRD5; The second LOTUS domain on Tudor-containing protein 5 (TDRD5)
      cd09976
      Location:296369
      LOTUS_3_TDRD5; The third LOTUS domain on Tudor-containing protein 5 (TDRD5)
      cd09985
      Location:498
      LOTUS_1_TDRD5; The first LOTUS domain on Tudor-containing protein 5 (TDRD5)
      pfam00567
      Location:471594
      TUDOR; Tudor domain
    4. NM_001199092.1NP_001186021.1  tudor domain-containing protein 5 isoform 3

      See identical proteins and their annotated locations for NP_001186021.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks multiple exons from the 5' end and contains an alternate 5' exon, and lacks an in-frame coding exon compared to variant 1. The resulting isoform (3) has a shorter N-terminus and lacks an internal segment compared to isoform 1.
      Source sequence(s)
      AK092142, BC089387
      UniProtKB/Swiss-Prot
      Q8NAT2
      Conserved Domains (2) summary
      cd04508
      Location:84130
      TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
      pfam00567
      Location:26149
      TUDOR; Tudor domain
    5. NM_001349923.1NP_001336852.1  tudor domain-containing protein 5 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1. Variants 3, 4, and 6 all encode the same isoform (2).
      Source sequence(s)
      AL160286, AL590987
      Consensus CDS
      CCDS1332.1
      Conserved Domains (4) summary
      cd09975
      Location:132201
      LOTUS_2_TDRD5; The second LOTUS domain on Tudor-containing protein 5 (TDRD5)
      cd09976
      Location:296369
      LOTUS_3_TDRD5; The third LOTUS domain on Tudor-containing protein 5 (TDRD5)
      cd09985
      Location:498
      LOTUS_1_TDRD5; The first LOTUS domain on Tudor-containing protein 5 (TDRD5)
      pfam00567
      Location:471594
      TUDOR; Tudor domain
    6. NM_173533.5NP_775804.2  tudor domain-containing protein 5 isoform 2

      See identical proteins and their annotated locations for NP_775804.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an in-frame coding exon compared to variant 1. The resulting isoform (2) lacks an internal segment compared to isoform 1. Variants 3, 4, and 6 all encode the same isoform (2).
      Source sequence(s)
      AK127370, BC043368, BC089387, DA418635
      Consensus CDS
      CCDS1332.1
      UniProtKB/Swiss-Prot
      Q8NAT2
      UniProtKB/TrEMBL
      A0A024R910
      Related
      ENSP00000294848.8, ENST00000294848.12
      Conserved Domains (4) summary
      cd09975
      Location:132201
      LOTUS_2_TDRD5; The second LOTUS domain on Tudor-containing protein 5 (TDRD5)
      cd09976
      Location:296369
      LOTUS_3_TDRD5; The third LOTUS domain on Tudor-containing protein 5 (TDRD5)
      cd09985
      Location:498
      LOTUS_1_TDRD5; The first LOTUS domain on Tudor-containing protein 5 (TDRD5)
      pfam00567
      Location:471594
      TUDOR; Tudor domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

      Range
      179591613..179691272
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005244935.4XP_005244992.1  tudor domain-containing protein 5 isoform X1

      See identical proteins and their annotated locations for XP_005244992.1

      UniProtKB/Swiss-Prot
      Q8NAT2
      Conserved Domains (5) summary
      cd04508
      Location:529575
      TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
      cd09975
      Location:132201
      LOTUS_2_TDRD5; The second LOTUS domain on Tudor-containing protein 5 (TDRD5)
      cd09976
      Location:296369
      LOTUS_3_TDRD5; The third LOTUS domain on Tudor-containing protein 5 (TDRD5)
      cd09985
      Location:498
      LOTUS_1_TDRD5; The first LOTUS domain on Tudor-containing protein 5 (TDRD5)
      pfam00567
      Location:471594
      TUDOR; Tudor domain
    2. XM_005244934.1XP_005244991.1  tudor domain-containing protein 5 isoform X1

      See identical proteins and their annotated locations for XP_005244991.1

      UniProtKB/Swiss-Prot
      Q8NAT2
      Conserved Domains (5) summary
      cd04508
      Location:529575
      TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
      cd09975
      Location:132201
      LOTUS_2_TDRD5; The second LOTUS domain on Tudor-containing protein 5 (TDRD5)
      cd09976
      Location:296369
      LOTUS_3_TDRD5; The third LOTUS domain on Tudor-containing protein 5 (TDRD5)
      cd09985
      Location:498
      LOTUS_1_TDRD5; The first LOTUS domain on Tudor-containing protein 5 (TDRD5)
      pfam00567
      Location:471594
      TUDOR; Tudor domain
    Support Center