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    DBI diazepam binding inhibitor, acyl-CoA binding protein [ Homo sapiens (human) ]

    Gene ID: 1622, updated on 17-Jun-2024

    Summary

    Official Symbol
    DBIprovided by HGNC
    Official Full Name
    diazepam binding inhibitor, acyl-CoA binding proteinprovided by HGNC
    Primary source
    HGNC:HGNC:2690
    See related
    Ensembl:ENSG00000155368 MIM:125950; AllianceGenome:HGNC:2690
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    EP; ACBP; ACBD1; CCK-RP
    Summary
    This gene encodes diazepam binding inhibitor, a protein that is regulated by hormones and is involved in lipid metabolism and the displacement of beta-carbolines and benzodiazepines, which modulate signal transduction at type A gamma-aminobutyric acid receptors located in brain synapses. The protein is conserved from yeast to mammals, with the most highly conserved domain consisting of seven contiguous residues that constitute the hydrophobic binding site for medium- and long-chain acyl-Coenzyme A esters. Diazepam binding inhibitor is also known to mediate the feedback regulation of pancreatic secretion and the postprandial release of cholecystokinin, in addition to its role as a mediator in corticotropin-dependent adrenal steroidogenesis. Three pseudogenes located on chromosomes 6, 8 and 16 have been identified. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in prostate (RPKM 97.8), liver (RPKM 93.2) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See DBI in Genome Data Viewer
    Location:
    2q14.2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (119366977..119372543)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (119800515..119806082)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (120124553..120130119)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene STEAP3 metalloreductase Neighboring gene STEAP3 antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:120011987-120012930 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:120013256-120014122 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:120016992-120017765 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11902 Neighboring gene uncharacterized LOC105373581 Neighboring gene NANOG hESC enhancer GRCh37_chr2:120049626-120050127 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:120051788-120052288 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:120052289-120052789 Neighboring gene chromosome 2 open reading frame 76 Neighboring gene NANOG hESC enhancer GRCh37_chr2:120064909-120065410 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11903 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16447 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16448 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16449 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11904 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16450 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16451 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11905 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:120189865-120190371 Neighboring gene transmembrane protein 37 Neighboring gene secretin receptor Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:120231245-120231796 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:120232347-120232897 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:120238515-120239026 Neighboring gene VISTA enhancer hs1941 Neighboring gene SCTR antisense RNA 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC70414

    General protein information

    Preferred Names
    acyl-CoA-binding protein
    Names
    GABA receptor modulator
    acyl coenzyme A binding protein
    acyl-Coenzyme A binding domain containing 1
    cholecystokinin-releasing peptide, trypsin-sensitive
    diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
    diazepam binding inhibitor (GABA receptor modulator, acyl-Coenzyme A binding protein)
    diazepam-binding inhibitor
    endozepine
    epididymis secretory sperm binding protein
    NP_001073331.1
    NP_001073332.1
    NP_001171488.1
    NP_001171512.1
    NP_001171513.1
    NP_001171514.1
    NP_001269562.1
    NP_001269563.1
    NP_001269564.1
    NP_001269565.1
    NP_001339361.1
    NP_065438.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001079862.4NP_001073331.1  acyl-CoA-binding protein isoform 3

      See identical proteins and their annotated locations for NP_001073331.1

      Status: REVIEWED

      Source sequence(s)
      AC016736
      Consensus CDS
      CCDS42740.1
      UniProtKB/Swiss-Prot
      B8ZWD2, B8ZWD6, B8ZWD7, P07108, P08869, Q4VWZ6, Q53SQ7, Q6IB48, Q9UCI8
      Related
      ENSP00000348116.3, ENST00000355857.8
      Conserved Domains (1) summary
      cd00435
      Location:286
      ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...
    2. NM_001079863.3NP_001073332.1  acyl-CoA-binding protein isoform 2

      See identical proteins and their annotated locations for NP_001073332.1

      Status: REVIEWED

      Source sequence(s)
      AC016736
      Consensus CDS
      CCDS42741.1
      UniProtKB/Swiss-Prot
      P07108
      Related
      ENSP00000376815.2, ENST00000393103.2
      Conserved Domains (1) summary
      cd00435
      Location:587
      ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...
    3. NM_001178017.3NP_001171488.1  acyl-CoA-binding protein isoform 4

      See identical proteins and their annotated locations for NP_001171488.1

      Status: REVIEWED

      Source sequence(s)
      AC016736
      Consensus CDS
      CCDS54391.1
      UniProtKB/Swiss-Prot
      P07108
      Related
      ENSP00000486361.1, ENST00000627305.2
      Conserved Domains (1) summary
      cd00435
      Location:74147
      ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...
    4. NM_001178041.4NP_001171512.1  acyl-CoA-binding protein isoform 5

      See identical proteins and their annotated locations for NP_001171512.1

      Status: REVIEWED

      Source sequence(s)
      AC016736
      Consensus CDS
      CCDS54390.1
      UniProtKB/Swiss-Prot
      P07108
      Related
      ENSP00000486281.1, ENST00000627093.2
      Conserved Domains (1) summary
      cd00435
      Location:55128
      ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...
    5. NM_001178042.4NP_001171513.1  acyl-CoA-binding protein isoform 1

      See identical proteins and their annotated locations for NP_001171513.1

      Status: REVIEWED

      Source sequence(s)
      AC016736
      Consensus CDS
      CCDS2126.1
      UniProtKB/TrEMBL
      A0A024RAF2
      Conserved Domains (1) summary
      cd00435
      Location:30103
      ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...
    6. NM_001178043.4NP_001171514.1  acyl-CoA-binding protein isoform 6

      See identical proteins and their annotated locations for NP_001171514.1

      Status: REVIEWED

      Source sequence(s)
      AC016736
      Consensus CDS
      CCDS74568.1
      UniProtKB/TrEMBL
      B8ZWD1
      Related
      ENSP00000442917.2, ENST00000535617.5
      Conserved Domains (1) summary
      cd00435
      Location:2396
      ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...
    7. NM_001282633.3NP_001269562.1  acyl-CoA-binding protein isoform 1

      See identical proteins and their annotated locations for NP_001269562.1

      Status: REVIEWED

      Source sequence(s)
      AC016736
      Consensus CDS
      CCDS2126.1
      UniProtKB/TrEMBL
      A0A024RAF2
      Related
      ENSP00000439012.1, ENST00000535757.5
      Conserved Domains (1) summary
      cd00435
      Location:30103
      ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...
    8. NM_001282634.3NP_001269563.1  acyl-CoA-binding protein isoform 1

      See identical proteins and their annotated locations for NP_001269563.1

      Status: REVIEWED

      Source sequence(s)
      AC016736
      Consensus CDS
      CCDS2126.1
      UniProtKB/TrEMBL
      A0A024RAF2
      Related
      ENSP00000386486.1, ENST00000409094.5
      Conserved Domains (1) summary
      cd00435
      Location:30103
      ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...
    9. NM_001282635.3NP_001269564.1  acyl-CoA-binding protein isoform 1

      See identical proteins and their annotated locations for NP_001269564.1

      Status: REVIEWED

      Source sequence(s)
      AC016736
      Consensus CDS
      CCDS2126.1
      UniProtKB/TrEMBL
      A0A024RAF2
      Related
      ENSP00000311117.4, ENST00000311521.8
      Conserved Domains (1) summary
      cd00435
      Location:30103
      ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...
    10. NM_001282636.3NP_001269565.1  acyl-CoA-binding protein isoform 7

      See identical proteins and their annotated locations for NP_001269565.1

      Status: REVIEWED

      Source sequence(s)
      AC016736
      UniProtKB/TrEMBL
      B8ZWD8
      Conserved Domains (1) summary
      cl00221
      Location:162
      ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...
    11. NM_001352432.3NP_001339361.1  acyl-CoA-binding protein isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC016736
      UniProtKB/TrEMBL
      B8ZWD8
      Related
      ENST00000460901.1
      Conserved Domains (1) summary
      cl00221
      Location:162
      ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...
    12. NM_020548.9NP_065438.1  acyl-CoA-binding protein isoform 1

      See identical proteins and their annotated locations for NP_065438.1

      Status: REVIEWED

      Source sequence(s)
      AC016736
      Consensus CDS
      CCDS2126.1
      UniProtKB/TrEMBL
      A0A024RAF2
      Conserved Domains (1) summary
      cd00435
      Location:30103
      ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      119366977..119372543
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      119800515..119806082
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)