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    Il12a interleukin 12a [ Mus musculus (house mouse) ]

    Gene ID: 16159, updated on 9-Dec-2024

    Summary

    Official Symbol
    Il12aprovided by MGI
    Official Full Name
    interleukin 12aprovided by MGI
    Primary source
    MGI:MGI:96539
    See related
    Ensembl:ENSMUSG00000027776 AllianceGenome:MGI:96539
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    p35; Ll12a; Il-12a; IL-12p35
    Summary
    Enables interleukin-12 beta subunit binding activity. Contributes to cytokine activity. Acts upstream of or within several processes, including T-helper 1 cell activation; defense response to protozoan; and positive regulation of T cell activation. Located in cell surface; cytoplasm; and extracellular space. Part of interleukin-12 complex. Is expressed in brain; lung; small intestine; testis; and thymus. Human ortholog(s) of this gene implicated in hepatitis C; hepatocellular carcinoma; and primary biliary cholangitis. Orthologous to human IL12A (interleukin 12A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in spleen adult (RPKM 2.9), lung adult (RPKM 1.2) and 8 other tissues See more
    Orthologs
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    Genomic context

    See Il12a in Genome Data Viewer
    Location:
    3 E1; 3 31.92 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (68597977..68605881)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (68690644..68698550)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene Iqcj and Schip1 fusion protein Neighboring gene schwannomin interacting protein 1 Neighboring gene STARR-seq mESC enhancer starr_07905 Neighboring gene predicted gene, 22073 Neighboring gene predicted gene, 57836 Neighboring gene STARR-positive B cell enhancer ABC_E7916 Neighboring gene STARR-positive B cell enhancer ABC_E11191 Neighboring gene STARR-positive B cell enhancer mm9_chr3:68521546-68521847 Neighboring gene STARR-seq mESC enhancer starr_07911 Neighboring gene STARR-seq mESC enhancer starr_07912 Neighboring gene STARR-seq mESC enhancer starr_07913 Neighboring gene predicted gene, 35584 Neighboring gene spermine synthase pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1) 
    • Endonuclease-mediated (8) 
    • Targeted (5)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC151228, MGC151232

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to cytokine activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    contributes_to cytokine activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables cytokine activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to growth factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables interleukin-12 beta subunit binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables interleukin-12 beta subunit binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables interleukin-12 receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables interleukin-27 binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of T cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within T-helper 1 cell activation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within T-helper 1 cell cytokine production IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cell population proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within cell population proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to lipopolysaccharide IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to virus ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within defense response to protozoan IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within defense response to protozoan IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in extrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in interleukin-12-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of interleukin-17 production ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of protein secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of negative regulation of vascular endothelial growth factor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of NK T cell activation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of T cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of T cell mediated cytotoxicity ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of T cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of dendritic cell chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of lymphocyte proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of mononuclear cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of natural killer cell activation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of natural killer cell mediated cytotoxicity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of smooth muscle cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of type II interferon production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of type II interferon production IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of type II interferon production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of tyrosine phosphorylation of STAT protein ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to UV-B ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to lipopolysaccharide ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of type II interferon production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of type II interferon production IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi lumen TAS
    Traceable Author Statement
    more info
     
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum lumen TAS
    Traceable Author Statement
    more info
     
    located_in endosome lumen TAS
    Traceable Author Statement
    more info
     
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    part_of interleukin-12 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of interleukin-12 complex IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    part_of interleukin-12 complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    interleukin-12 subunit alpha
    Names
    CLMF p35
    IL-12 p35 subunit
    IL-12 subunit p35
    cytotoxic lymphocyte maturation factor 35 kDa subunit
    interleukin 12a p35 subunit
    interleukin-12 p35 subunit

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159424.3NP_001152896.2  interleukin-12 subunit alpha isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC121306
      UniProtKB/Swiss-Prot
      P43431
      UniProtKB/TrEMBL
      F8WI71, Q549G3
      Related
      ENSMUSP00000029345.6, ENSMUST00000029345.12
    2. NM_001410417.1NP_001397346.1  interleukin-12 subunit alpha isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AC121306
      UniProtKB/TrEMBL
      F8WI71
    3. NM_001410418.1NP_001397347.1  interleukin-12 subunit alpha isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC121306
    4. NM_001410419.1NP_001397348.1  interleukin-12 subunit alpha isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC121306
    5. NM_001410420.1NP_001397349.1  interleukin-12 subunit alpha isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC121306
    6. NM_008351.4NP_032377.1  interleukin-12 subunit alpha isoform 2 precursor

      See identical proteins and their annotated locations for NP_032377.1

      Status: VALIDATED

      Source sequence(s)
      AC121306
      Consensus CDS
      CCDS17400.1
      UniProtKB/Swiss-Prot
      P43431
      UniProtKB/TrEMBL
      F8WI71, Q549G3
      Related
      ENSMUSP00000103446.3, ENSMUST00000107816.5
      Conserved Domains (1) summary
      pfam03039
      Location:17215
      IL12; Interleukin-12 alpha subunit

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      68597977..68605881
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)